Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P10145 (
IL-8
)
23,849
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-8
(
IL-8
;
CXCL8
) has been shown to play a role in multiple cellular processes. Here, we report an additional role of
IL-8
as a growth and essential survival factor for normal human urothelial cells. Supplementing exogenous recombinant human
IL-8
to normal urothelial cells promoted cell growth through the Akt pathway. Inhibition of
IL-8
expression by small inhibitory RNA (siRNA) caused normal urothelial cells to die. Addition of recombinant human
IL-8
rescued the normal urothelial cells treated with
IL-8
siRNA. This rescue effect could be blocked by antibodies to the IL-8 receptor CXCR1 but not by CXCR2, suggesting that normal urothelial cells normally have
IL-8
autocrine or paracrine activity for survival and growth mediated by CXCR1.
IL-8
mRNA levels were lower in samples from patients with interstitial cystitis, a
urinary bladder disorder
associated with urothelial cell dysfunction and/or loss. Taken together, these results suggest that
IL-8
is an important normal urothelial growth factor and is necessary for normal urothelial cell survival in vitro and in vivo. Lower
IL-8
expression levels in the urinary bladder may contribute to pathophysiology of interstitial cystitis.
...
PMID:Interleukin-8 is essential for normal urothelial cell survival. 1953 67
