Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P10145 (IL-8)
 23,849 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Qualitative and quantitative precipitin reactions are given of the polysaccharides K60, K61, K65, K67-69, K70, K71, K73, and K83, also of depyruvylated K1. As expected, the last reacts more strongly in antipneumococcal (anti-Pn) VIII and X than does intact K1. K65 and K67 precipitate much of the same large fraction of anti-PnXXIII as does K47, showing that K65 and K67 also possess lateral non-reducing end-groups of L-rhamnose. The massive reaction of K83 in anti-PnII confirms the chemically demonstrated non-reducing end-groups of D-glucuronic acid in the repeating unit, Such groups, or 1,2-linked D-glcA, will probably also be found in K71.
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PMID:[Cross reactions of higher type-specific capsular polysaccharides of Klebsiella in antipneumococcal sera]. 1 94

The immune responses of 26 Angus-Hereford fetuses and neonates to Escherichia coli O26:K60:NM were studied after bacterin or saline solution was injected (in utero) into the amniotic fluid. Calves were euthanatized at birth or were orally revaccinated; some were challenge exposed with live organisms. The hemolytic plaque assay was used to determine the presence of cells producing immunoglobulins M, G1, and G2 (IgM, IgG1, and IgG2) in 4 segments of the small intestine, mesenteric lymph nodes, and spleen. The passive hemagglutinin activity of intestinal washings was also determined. Anti-O26 passive hemagglutinin activity in the intestinal washings of principal calves was greater than in that of control calves, but in a given segment of the small intestine, usually this activity was relatively small and less consistent than the plaque-forming response. Greater numbers of plaque-forming cells were observed in the small intestine of 14 of the 15 principal calves when compared with the control calves tested.
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PMID:Immune responses of the bovine fetus and neonate to Escherichia coli: plaque-forming and intestinal immune responses. 33 1

Twenty Holstein-Friesian male calves were obtained within 4 hours after bith (colostrum deprived) and allotted to 1 of 4 groups, each given a different feeding: colostrum, milk replacer, polyvinylpyrrolidone (PVP), and saline solution (0.85% NaCl). Each calf was fed 2 L of the respective diets every 12 hours. Rectal temperatures were recorded and blood samples were collected immediately before each feeding. At approximately 27 hours of age, all calves were inoculated orally with 1.5 X 10(10) viable organisms of a septicemia-producing Escherichia coli serotype O26: K60:NM. Within 8 hours, all calves had diarrhea. Coli-septicemia (E coli cultured from liver, spleen, and cardiac blood) was present in 1 of the 5 calves fed colostrum, in 5 or the 5 calves fed milk replacer, in 5 of the 5 calves fed PVP, and in 4 of the 5 calves fed saline solution. At necropsy of the calves (12 to 48 hours after oral inoculation), the same organism was isolated by cultural technique from small intestines of 19 of the 20 calves. Serum immunoglobulin G concentrations increased (P less than 0.01) in calves fed the colostrum diet in sharp contrast to the agammaglobulinemia occurring in calves fed the milk replacer, PVP, or saline solution. Results indicate that colostrum fed to the calf soon after birth provides protection from colisepticemia, but does not prevent the diarrhea of colibacillosis.
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PMID:Resistance of neonatal calves given colostrum diet to oral challenge with a septicemia-producing Escherichia coli. 33 27

Macroscopic, light and electron microscopic alterations in ligated rabbit intestinal loops challenged with five standard enterotoxigenic Escherichia coli (ETEC) and twenty-three enteropathogenic E. coli (EEC-I) strains, freshly isolated from infantile enteritis cases, were investigated. Only two O26 : K60 : H11 strains produced enterotoxin. Their living cultures, sterile filtrates of the fluid medium and ultrasonic lysates of the bacteria resulted in pronounced hypersecretion of the intestinal epithelium followed by fluid accumulation and loop dilatation. These two E. coli strains, similarly as the other loop-negative EEC-I strains, were able to penetrate into the intestinal epithelium. In contrast to the standard ETEC strains, the EEC-I bacteria, adhering to the brush border, intruded into the microvilli, multiplied on the outer epithelial cell membrane making close contact with it and, causing, shedding of microvilli, penetrated into enterocytes becoming enclosed in membrane-bound phagosome-like vacuoles, appeared in the lamina propria and elicited mild focal polymorphonuclear infiltration.
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PMID:Pathogenic effect of enterotoxigenic Escherichia coli and Escherichia coli causing infantile diarrhoea. 34 57

Antibodies directed against the protein constituents of the outer envelope membrane of Escherichia coli O26 K60 were demonstrated in antisera elicited in rabbits against three different preparations of the bacterium. Outer membraned solubilized by sodium dodecyl sulphate were applied to the antisera in an interfacial precipitin test, followed by polyacrylamide gel electrophoretic analysis of the resulting immunecomplexes. Protein profiles showed a complete outer membrane protein pattern, indicating the antigenic character of these proteins. Antisera containing antibodies against outer membrane proteins and free of reactive antibodies against lipopolysaccharide showed relatively low agglutinating activities against the bacteria. The antibodies against the protein constituents of the outer membrane belong mainly to the 7S class immunoglobulins, as indicated by 2-mercaptoethanol treatment of the antisera.
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PMID:Antibodies against outer membrane proteins in rabbit antisera prepared against Escherichia coli O26 K60. 34 33

The capacity of a human enteropathogenic Escherichia coli (EPEC) strain serotype O26:K60:H11, to adhere to the mucosa of the human fetal small intestine was shown to be plasmid mediated. Adherence was transferred at a high frequency in a long-term conjugal mating experiment to E. coli K-12 and was lost by treatment of the EPEC strain with the curing agent ethidium bromide. Analysis of radioactively labeled DNA from lysates of the EPEC, transconjugant, and cured strains indicated that adherence was correlated with the presence of plasmid DNA species with an approximate average molecular weight of 56 X 10(6). Resistance to the antibiotics spectinomycin, streptomycin, sulfonamides, and tetracycline and production of colicin Ib were all transferred in long-term mating and lost upon curing coordinately with the property of adherence. In conjugal mating experiments of limited duration between E. coli K-12 strains, however, segregation of colicin production and mucosal adherence from multiple drug resistance was observed. Analysis of plasmid DNA of segregant transconjugant strains confirmed the presence in the 56 X 10(6)-dalton plasmid species of two previously unresolved components, pLG101 designating the ColIb plasmid which also carries the determinant for mucosal adherence and pLG102 representing the slightly smaller multiple drug resistance plasmid.
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PMID:Adherence of an enteropathogenic strain of Escherichia coli to human intestinal mucosa is mediated by a colicinogenic conjugative plasmid. 36 58

Our immunocytochemical investigation of the magnocellular neuroendocrine cells in the cat hypothalamus reveals a mixture of vasopressin (VP)- and oxytocin (OT)-containing neurons in the supraoptic (NSO), the paraventricular (NPV) and in five accessory nuclei (NAC). We describe the lateral hypothalamic nucleus (NLH), a new accessory nucleus, lying at the junction of the internal capsule and pallidum, and possibly involved in drinking behavior. Previously characterized incompletely in mammals, the four other accessory nuclei consist of the circularis (NC), anterior fornical (NAF), posterior fornical (NPF) and retrochiasmatic (NRC). The two peptidergic cell types, VP and OT, are equally mixed in the NPV and the NAC, but in the NSO VP neurons predominate. The perikarya of these VP and OT neurons do not show distinct morphological differences at the level of light microscopy. The organization of magnocellular neuroscretory neurons in the cat hypothalamus closely resembles that described in other mammals with the exception of the unique presence of the lateral hypothalamic accessory nucleus.
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PMID:Immunocytochemical identification of vasopressinergic and oxytocinergic neurons in the hypothalamus of the cat. 42 Dec 43

Sodium fluoride exhibited a dose dependent inhibitory effect on protein and DNA synthesis at concentrations from 1.3 mM in growing LS cells. The activity of ornithine decarboxylase (ODC) was slightly stimulated by 0.5 mM-NAF, but inhibited at 1.3 mM and above. The reduced enzyme activity seemed to be due to a reduced de novo formation of the enzyme caused by an inhibition of the protein synthesis. In spite of a reduction of ODC-activity, fluoride had no effect on the cellular polyamine content during the experimental period (10 hours).
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PMID:Effect of sodium fluoride on protein and DNA synthesis, ornithine decarboxylase activity, and polyamine content in LS cells. 47 45

A procedure in which transfer of genetic information between genetically distinct derivatives of strain K60 of Pseudomonas solanacearum occurred is described. Genetical analysis of recombinants demonstrated the transfer of an unselected marker, and the linkage of genes determining resistance to streptomycin and rifampicin.
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PMID:Evidence for the cotransfer of genetic markers in Pseudomonas solanacearum strain K60. 75 79

The effect of immune bovine lactoserum (BLS) antipolyvalent enteropathogenic Escherichia coli on bacterial growth, viability and bacteria-induced fluid accumulation was examined in rabbit ileal loops. Human enteropathogenic E. coli strains 0125:K70 (B15), 0111:K58 (B4) and 055:K59 (B5) (1-3 X 10(9) per inoculum) induced secretion of 4-6 ml fluid per 10 cm loop. This effect was inhibited effectively by BLS (corresponding to 50 mg IgG 1 per loop) while the viability of bacteria counts decreased 2-25 fold compared with bovine serum albumin. E. coli 026:K60 (B6), 0126:K71 (B16) and 0127:K63 (B8) caused moderate secretion (2-3 ml/10 cm loop) that was significantly neutralized by BLS. E. coli 086:K61 (B7) and 0128:K67 (B12) did not give positive loops. The fluid secretion was shown to be dose dependent for E. coli 0125:K70 (B15) over the range from 2.5 X 10(9) to 8 X 10(7) bacteria/loop. The titration of the effect of BLS on fluid secretion caused by the same strain revealed a dose dependent decrease. The best inhibition was obtained with 100 mg BLS/loop, the highest dose tested.
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PMID:Passive oral immunization with bovine immunoglobulins: enterpathogenic Escherichia coli from infants and bovine anti-E. coli lactoserum assayed in the rabbit ileal loop model. 76 10


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