Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P08908 (5-HT1A)
 5,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tryptamine has been studied for its effect on the 5-hydroxytryptamine-induced responses of the dorsal root ganglion neurons in rat with intracellular registration of the membrane potential and conductance and application of drugs from micropipettes under pressure. It was found that tryptamine applied in high concentrations acted like 5-hydroxytryptamine; but in the concentration range when it has no effect on the membrane potential and membrane conductance it either enhanced (10(-7) mol/l) or diminished (10(-5) mol/l) 5-hydroxytryptamine responses mediated by 5-HT1A- but not by 5-HT2-receptors. Harmane acted like tryptamine, but its derivatives either only enhanced or only inhibited the 5-hydroxytryptamine effects. The allosterical nature of 5-hydroxytryptamine-modulating action of tryptamine, harmane and its derivatives is discussed.
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PMID:[Tryptamine as an endogenous modulator of neuronal sensitivity to serotonin]. 277 Sep 17