Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P08908 (5-HT1A)
 5,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The role of the serotoninergic system in the control of prolactin (PRL) secretion has been studied in prepubertal male rats. Serum PRL concentration was measured in 16-day-old male rats at different times after the administration of 5-hydroxytryptophan (5-HTP), a precursor of serotonin (5-HT) synthesis, alone or in combination with fluoxetine, a specific inhibitor of 5-HT uptake; DL-p-parachlorophenylalanine (PCPA), an inhibitor of 5-HT synthesis; and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective agonist of 5-HT1A receptors. Also, serum PRL concentration and pituitary content were measured after 5-HTP administration in castrated males implanted with silastic capsules containing testosterone or 5 alpha-androstane-3 alpha,17 beta-diol (alpha-diol). We found that: the reduction in serotoninergic activity after PCPA administration did not modify serum PRL concentrations; the stimulatory effect of 5-HTP on PRL secretion was not observed before day 16; the effects of 5-HTP or 5-HTP and fluoxetine were similar in intact and orchidectomized males; a significant increase in PRL secretion took place after 8-OH-DPAT administration; the duration of the stimulatory effect of 5-HTP increased after alpha-diol treatment; and pituitary PRL content increased after 5-HTP injection in intact males and decreased in castrated males treated with testosterone or alpha-diol.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Serotoninergic control of prolactin secretion in prepubertal male rats. 752 55

We previously reported the presence of serotonin (5-HT) in testes from golden hamster, a photoperiodic species which is a useful model for the study of states of male (in)fertility. The aims of this study were to investigate: (1) the presence of intrinsic sources of 5-HT in the testis; (2) the role of 5-HT in in vitro androgen production; (3) the serotoninergic receptor subtypes in the testis, and (4) the existence of interactions among the 5-HT receptors and the testicular catecholaminergic and corticotropin-releasing hormone (CRH) systems. Immunohistochemical studies revealed the presence of tryptophan hydroxylase, a 5-HT-biosynthetic enzyme, in interstitial cells which show the characteristic punctate chromatin pattern of Leydig cells. We describe an inhibitory action of 5-HT on testosterone, dihydrotestosterone, and androstane-3alpha,17beta-diol production from testes of peripubertal and adult hamsters maintained in a long photoperiod (14/10 h light/dark), and adult animals exposed to a short photoperiod (6/18 h light/dark). By using several agonists and antagonists of 5-HT receptors, we characterized 5-HT1A and 5-HT2A receptor subtypes involved in the inhibitory action of this neurotransmitter on human chorionic gonadotropin stimulated cyclic adenosine monophosphate and testosterone production. CRH also produced a negative modulation of both parameters, but epinephrine and norepinephrine, through alpha1/beta1-adrenergic receptors, exerted a stimulatory action. 5-HT1A, 5-HT2, and CRH antagonists showed that the testicular activity of the serotoninergic system, but also the alpha1/beta1-adrenergic receptor system, is mediated by CRH. Moreover, interactions between the 5-HT2A receptor system and alpha1/beta-adrenergic receptors have been established. Thus, these data suggest that alpha1/beta1-adrenergic receptors are involved in the local regulatory action exerted by 5-HT on steroidogenesis through a 5-HT2-receptor-mediated response and the CRH system.
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PMID:Interactions between testicular serotoninergic, catecholaminergic, and corticotropin-releasing hormone systems modulating cAMP and testosterone production in the golden hamster. 1209 15