Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P08908 (
5-HT1A
)
5,574
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We studied the
5-HT1A
receptor gene in 50 mood disorders and 50 normal volunteers. The
5-HT1A
receptor gene was amplified by polymerase chain reaction and sequenced by the dideoxy method. The sequence of the
5-HT1A
receptor encodes a protein of 422 amino acids, that is, one amino acid longer than the reported sequence (Kobilka et al. 1987). The DNA sequence at positions 454 to 459 is CGC GCC GCT, not CCG
CGT
, and the amino acids sequence at these positions is changing from proline arginine to arginine alanine alanine. These differences, however, were observed in both mood disorders and controls. One silent polymorphism, CTG to GTA at position 294, was found. These results suggest that the
5-HT1A
receptor gene is intact in mood disorders.
...
PMID:The gene encoding the 5-HT1A receptor is intact in mood disorders. 761 60
