Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P08908 (5-HT1A)
 5,574 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is shown that a selective agonist of 5-HT1A receptors 8-OH-DPAT in a low dose (0.1 mg/kg), which is known to affect mainly the presynaptic 5-HT1A receptors increased the immune response at the peak of reactions (the forth or fifth day after immunization with sheep red blood cells - SRBC) in CBA mice and Wistar rats. Treatment of the animals with the drug 15 min prior to antigen injection raised the number of plaque-forming cells (lgM-PFC) and rosette-forming cells (RFC) in the spleen. The preliminary blockade of 5-HT1A receptor with a selective antagonist of 5-HT1A receptors WAY-100635 (0.1 mg/kg) prevented the immunostimulating effect of 5-HT 1A receptors agonist 8-OH-DPAT, whereas WAY-100635 administration alone in the same dose didn't change the immune response. Activation of 5-HT1A receptors under conditions of electrical lesion of 5-HTergic neurons of the nucleus raphe was unable to enhance the immune reactions, as it did in sham-operated rats. The data obtained indicate that the somatodendric 5-HT1A autoreceptors are involved in immunomodulation.
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PMID:[Presynaptic 5-HT1A receptors in immunomodulation]. 1807 89

The development of the immune reaction after the activation or blockade of presynaptic 5-HT1A receptors, respectively, with a selective agonist or antagonist depends on specific behavioral patterns. Agonist of 5-HT1A receptors 8-OH-DPAT (0.1 mg/kg 15 min prior to immunization) did not change the number of IgM plaque-forming cells in the spleen of aggressive mice at the peak of the immune response (the 4-th day after immunization) but increased their number in submissive animals, in which the baseline immune response was lower than in aggressive animals. Administration of WAY-100635 (0.1 mg/kg 30 min prior to immunization) resulted in a decrease in the immune reaction in aggressive mice and led to its increase in submissive animals. It is suggested that the immunomodulatory effects of drugs affecting the activity of presynaptic 5-HT1A receptors are related to changes in the functional state of these receptors and the interaction between serotonin- and dopaminergic systems.
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PMID:[Involvement of presynaptic 5-HT1A receptors in immunomodulation under conditions of psychoemotional state]. 1944 89