Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P06889 (
Mol
)
630,302
document(s) hit in 31,850,051 MEDLINE articles (0.25 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Mol
630302
Sep
39662
Gen
11089
ATP
10058
insulin
9134
cytokine
8422
NMR
6875
p53
6846
polypeptide
6575
histone
5882
endoplasmic reticulum
5777
collagen
5636
ATPase
4671
ubiquitin
4225
fused
4219
caspase-3
4112
lipopolysaccharide
3800
tumor necrosis factor
3754
tRNA
3679
TNF
3616
glycoprotein
3351
p38
3348
Pseudomonas
3306
proteasome
3294
SDS
3243
MAPK
3218
IL-6
3184
estrogen receptor
3066
superoxide dismutase
2981
Bcl-2
2950
tyrosine kinase
2855
gut
2854
AMP
2833
AKT
2804
ERK1
2763
ERK
2711
GTP
2706
mTOR
2655
phosphatase
2620
membrane protein
2582
interferon
2483
vascular endothelial growth factor
2482
catalase
2422
threonine
2410
PI3K
2363
p21
2348
ADP
2348
CD4
2261
epidermal growth factor receptor
2064
endonuclease
2038
UTR
2025
fibronectin
2016
dimeric
2010
lymphoid
2002
membrane-bound
1964
calmodulin
1964
myosin
1952
axonal
1942
RNA polymerase II
1933
GSH
1894
epidermal growth factor
1886
alkaline phosphatase
1877
catenin
1869
GTPase
1852
Rho
1845
chemokine
1809
telomeric
1778
serum albumin
1774
IFN
1763
androgen receptor
1752
cytochrome c
1739
hemoglobin
1736
lectin
1714
cryptic
1670
albumin
1656
CD8
1654
cytochrome P450
1638
reductase
1637
JNK
1616
LPS
1613
SOD
1604
matrix metalloproteinase
1586
extracellular signal-regulated kinase
1581
p65
1580
IL-8
1566
X-linked
1539
histone H3
1529
thymus
1513
IL-10
1505
cyclin D1
1498
erythroid
1487
glucocorticoid receptor
1465
nuclear receptor
1461
nitric oxide synthase
1448
DNase I
1428
AP-1
1427
c-Jun
1425
olfactory
1425
inducible nitric oxide synthase
1418
spermatozoa
1394
cyclin
1392
cytochrome
1388
NAD
1380
histone deacetylase
1354
NADPH
1353
angiotensin II
1342
MEK
1335
lactate dehydrogenase
1333
mitogen-activated protein
1330
growth hormone
1310
DNA-binding domain
1303
E-cadherin
1289
peroxidase
1284
PKC
1265
cytochrome b
1258
amyloid precursor protein
1254
phosphatidylinositol 3-kinase
1246
ROS
1241
RNase
1238
microsomal
1235
ras
1233
interleukin-6
1228
glutathione peroxidase
1226
EGFR
1220
G protein-coupled receptor
1219
methyltransferase
1218
leptin
1209
TNF-alpha
1204
zinc finger
1202
adenylate cyclase
1198
aromatase
1197
IL-4
1196
brain-derived neurotrophic factor
1195
VEGF
1193
prolactin
1190
TLR4
1189
osteogenic
1188
proliferating cell nuclear antigen
1179
c-fos
1172
helicase
1155
unknown function
1152
GABA
1148
transcriptional activator
1144
STAT3
1143
progesterone receptor
1117
major histocompatibility complex
1117
thyroid hormone
1113
vimentin
1108
kit
1096
NADH
1094
nuclear protein
1090
IgE
1089
MHC
1085
PARP
1071
RhoA
1056
cage
1049
adenylyl cyclase
1048
MAP kinase
1037
Sp1
1036
c-myc
1025
more...
Disease
cancer
46002
tumor
33353
breast cancer
8817
Alzheimer's disease
6481
diabetes
6177
tumorigenesis
5231
carcinoma
4868
tumor growth
4544
obesity
4374
ischemia
4297
hepatocellular carcinoma
4098
carcinogenesis
3813
prostate cancer
3784
HIV
3399
tumor progression
3394
cold
3308
SDS
3257
lung cancer
3235
leukemia
3113
Parkinson's disease
3068
colorectal cancer
2992
hypertension
2903
atherosclerosis
2826
adenocarcinoma
2774
melanoma
2735
depression
2553
asthma
2536
metastases
2530
stroke
2442
MCF
2373
type 2 diabetes
2358
heart failure
2334
glioma
2217
schizophrenia
2036
neuroblastoma
1950
infectious diseases
1949
GSH
1896
immunodeficiency
1880
malaria
1817
cardiovascular disease
1810
tuberculosis
1805
squamous cell carcinoma
1805
myocardial infarction
1798
Mycobacterium
1794
ovarian cancer
1790
lymphoma
1770
virus infection
1766
colon cancer
1719
gastric cancer
1712
autism
1695
plaque
1516
multiple sclerosis
1424
glioblastoma
1422
influenza
1410
uterus
1402
dementia
1394
cystic fibrosis
1388
rheumatoid arthritis
1369
sepsis
1325
amyotrophic lateral sclerosis
1312
pancreatic cancer
1312
Huntington's disease
1282
epilepsy
1276
sepsis
1245
non-small cell lung cancer
1183
herpes simplex
1150
pertussis
1143
osteoporosis
1127
acute myeloid leukemia
1122
hyperglycemia
1121
ATM
1106
multiple myeloma
1079
chronic obstructive pulmonary disease
1038
cognitive impairment
1033
retinoblastoma
1001
metabolic syndrome
991
renal cell carcinoma
977
cholera
976
osteosarcoma
969
infertility
957
coronary artery disease
950
autoimmune disease
935
systemic lupus erythematosus
926
cervical cancer
924
anemia
911
cardiomyopathy
909
myocardial ischemia
905
osteoarthritis
904
hepatitis B
893
arthritis
879
cerebral ischemia
876
cirrhosis
865
bladder cancer
806
hepatitis C
793
pheochromocytoma
784
lung disease
782
liver cancer
778
Duchenne muscular dystrophy
778
cytomegalovirus
772
pulmonary hypertension
767
West
762
Autism
760
liver disease
744
bipolar disorder
741
dehydration
740
B-cell lymphoma
739
inflammatory bowel disease
738
sarcoma
735
SEM
734
worms
734
Infection
729
fatty liver
728
pulmonary fibrosis
720
renal disease
716
fits
716
primary tumor
715
pneumonia
714
aggressiveness
703
Epstein
695
dysplasia
693
mental retardation
691
AIDS
685
heart disease
677
mental retardation
671
chronic myeloid leukemia
646
lung carcinoma
622
liver cancer
621
major depressive disorder
615
Blocking
609
mole
607
brain tumor
607
type 1 diabetes
602
liver fibrosis
597
muscular atrophy
595
glioblastoma multiforme
585
preeclampsia
584
blindness
584
Yersinia
575
colitis
572
endometrial cancer
562
mammary tumor
561
epithelial ovarian cancer
560
mole
559
genetic disorder
543
bacterial infection
542
SCID
538
suicide
533
myopathy
532
APC
529
acute lymphoblastic leukemia
525
Klebsiella
514
endometriosis
509
SARS
508
skin cancer
503
NAME
502
TEM
502
tumor angiogenesis
498
malnutrition
493
idiopathic pulmonary fibrosis
485
TEM
484
more...
Symptom
pain
3255
starvation
2103
seizures
1441
collapse
770
weakness
662
ataxia
573
respiratory distress
571
functional recovery
558
hyperoxia
548
anesthesia
516
diarrhea
516
fatigue
358
acidity
340
exhaustion
256
overweight
250
analgesia
249
tremor
244
hypotonia
237
hypothermia
221
thinning
217
cachexia
173
dystonia
170
acute stress
169
vomiting
145
headache
139
splenomegaly
136
abdominal pain
133
HSA
130
anorexia
128
memory loss
127
hypercapnia
123
masculinization
118
spasticity
116
stigma
115
cough
114
angina
112
cerebellar ataxia
110
hepatomegaly
107
DNA marker
100
nausea
96
agitation
96
Neuropathic pain
96
twitching
95
insomnia
89
dyspnea
85
constipation
81
discomfort
81
dry eye
77
discomfort
75
hepatosplenomegaly
73
bone pain
69
ophthalmoplegia
66
erythema
65
chills
59
low back pain
58
back pain
58
bitter taste
58
lethargy
55
fasciculation
52
acute pain
51
skin damage
51
syncope
48
hunger
48
bradykinesia
46
flushing
46
chest pain
46
pelvic pain
45
arthralgia
45
myoclonus
44
eds
44
myalgia
44
neurological disability
43
wheezing
41
despair
39
nausea and vomiting
38
Hudson
37
Ill
36
anosmia
35
dysarthria
33
general problem
32
regurgitation
31
cancer pain
31
menopausal symptoms
30
CSR
30
Scratch
30
spasm
28
dizziness
28
shortness of breath
27
sleepiness
27
apathy
26
polyuria
25
vertigo
25
Wind
25
incoordination
24
rundown
24
tinnitus
23
abnormal gait
23
fever of unknown origin
23
microbial colonization
23
Anoxia
22
distraction
22
muscle stiffness
20
POA
20
Stiffness
20
chorea
20
paresis
18
sore throat
18
cyanosis
18
bloating
17
exertional dyspnea
17
tense
17
hypertonia
16
tachypnea
16
numbness
16
autodigestion
16
dry skin
16
rigors
15
Depressive symptoms
15
pallor
15
sneezing
15
male subfertility
15
Halo
15
Spots
15
physical appearance
14
hot flushes
14
paraparesis
14
Fluctuation
14
photophobia
13
muscle rigidity
13
epigastric pain
13
ACHE
13
hemoptysis
13
orofacial pain
13
disturbed balance
12
joint stiffness
12
ataxic gait
12
paresthesia
12
skin irritation
12
polydipsia
12
Decreased activity
12
rhinorrhea
11
loss of equilibrium
10
abdominal discomfort
10
hemiplegia
10
hot flashes
10
dental pain
9
stridor
9
asthenia
9
nasal congestion
9
female puberty
9
hoarseness
9
sciatica
9
intention tremor
8
muscle cramps
8
impaired motor coordination
8
urinary frequency
8
catatonia
8
Hyperekplexia
8
ketonuria
8
heartburn
8
more...
Drug
lysine
4511
Mutagen
2811
DNase I
1447
ROS
1241
NADH
1085
Gel
1040
MAP
891
IFN-gamma
827
Asn
790
ascorbate
767
IL-2
759
CSF
731
caffeine
634
Leaf
591
ABC
561
vitamin E
551
ICI
492
lactose
483
Glutathione
379
EE2
369
Angiotensin II
343
FAD
340
p75
289
ETS
274
G418
272
Capsicum
241
citric acid
241
Ethanol
241
Heme
238
Asthma
238
Forskolin
234
THF
233
Estrogens
230
CAM
228
ZnO
227
Retinoic acid
223
Parkin
222
Parkin
222
Alanine
222
PTH
218
CTX
211
ROC
210
Fragment
203
ampicillin
201
Activin
194
CaCl2
194
TAT
190
TiO2
188
Nephron
188
CaCl2
188
CaCl2
188
DM1
185
Taxol
185
nitroglycerin
163
Albumin
154
DHT
148
Adriamycin
147
DHT
146
NH3
145
Growth hormone
143
Growth hormone
140
Glucagon
140
AraC
136
Herceptin
134
uPA
134
BH4
133
Kenyan
132
G-CSF
129
Spectrum
125
ALA
123
BLM
123
Imatinib
121
Histamine
121
Vitamin E
120
GEO
118
pyridoxal phosphate
117
TTC
117
Indomethacin
117
IFN-beta
115
Vitamin A
114
CTX
112
CTX
111
MRC
110
Simvastatin
109
EPA
109
ETA
107
Sorafenib
104
Ouabain
102
L-tyrosine
99
Bifidobacterium
99
Spectrum
98
Glide
98
AGG
98
ADM
97
R1881
97
niacin
96
Bortezomib
95
FLP
94
NAG
94
Paraffin
93
ADR
91
CDP
91
Fluorescein
89
Amiloride
88
PCP
85
RFP
85
Allergen
82
Portal
81
Arsenic trioxide
80
Amiloride
80
Gefitinib
79
SiO2
78
ENT
77
Itraconazole
77
HCH
77
CoCl2
77
CoCl2
77
NVP
76
IL-1ra
76
CCL
75
ACT
75
Glycerol
75
TAC
72
AZT
71
AZT
71
Docetaxel
70
Biopolymers
70
Fructose
70
-deoxyadenosine
69
Gleevec
68
DEX
68
PTC
65
TAK
65
Gelatin
63
Bevacizumab
61
Fluorescein
60
Luteinizing
60
Cetuximab
59
CPT-11
59
AMC
58
VCR
57
Fraction
57
PCB
56
Propofol
56
Coral
55
Captopril
54
Ranitidine
53
CTC
53
Vitamin K
52
IL-11
51
ZnCl2
51
ZnCl2
51
Oxaliplatin
51
Carotenoid
50
MOF
49
Emodin
49
Silica
49
NBT
49
Rosiglitazone
49
Emodin
48
more...
Enzyme
mitogen-activated protein kinase
11016
protein kinase
9771
ERK
7521
RNA polymerase
5325
luciferase
5138
ATPase
4932
protein kinase C
4123
superoxide dismutase
3496
proteasome
3420
caspase-3
3217
catalase
3041
focal adhesion kinase
2948
reverse transcriptase
2344
trypsin
2164
peroxidase
2095
endonuclease
2039
MEK
2007
RNase
1930
alkaline phosphatase
1891
RNase
1843
glutathione S-transferase
1722
calcineurin
1633
DNA polymerase
1503
phospholipase C
1430
lactate dehydrogenase
1393
beta-galactosidase
1359
AMP-activated protein kinase
1347
PARP
1340
adenylate cyclase
1257
glutathione peroxidase
1252
phosphatidylinositol 3-kinase
1252
AMPK
1171
cdc2
1107
phosphodiesterase
1073
renin
1006
lysozyme
978
thrombin
954
topoisomerase
949
collagenase
924
topoisomerase
884
acetylcholinesterase
869
complex I
866
thymidine kinase
850
chloramphenicol acetyltransferase
837
NADPH oxidase
810
aspartate aminotransferase
791
P-glycoprotein
767
alanine aminotransferase
763
cytochrome oxidase
759
NADPH oxidase
753
creatine kinase
745
GSK
743
NO synthase
740
tyrosine hydroxylase
723
phospholipase A2
709
APC
704
lipase
699
beta-glucuronidase
695
DNase
662
caspase-9
657
dihydrofolate reductase
638
AMPK
637
ribonuclease
629
ribonuclease
629
transcriptase
628
glyceraldehyde-3-phosphate dehydrogenase
626
phosphoinositide 3-kinase
621
ATP synthase
615
caspase-8
602
chymotrypsin
587
IKK
564
S1 nuclease
561
DNA methyltransferase
555
guanylate cyclase
531
kinesin
529
ACE
517
glutathione reductase
512
urokinase-type plasminogen activator
511
alcohol dehydrogenase
498
glyceraldehyde-3-phosphate dehydrogenase
497
acid phosphatase
482
neuraminidase
480
histone acetyltransferase
475
elastase
451
tyrosinase
451
MAP
448
caspase-1
445
NOS
440
succinate dehydrogenase
437
CD10
425
glyceraldehyde-3-phosphate dehydrogenase
413
chitinase
401
CaMKII
388
glutamine synthetase
387
glyceraldehyde-3-phosphate dehydrogenase
384
glyceraldehyde-3-phosphate dehydrogenase
383
micrococcal nuclease
378
glucose-6-phosphate dehydrogenase
372
HSD
371
pyruvate dehydrogenase
369
NQO1
361
hexokinase
361
pyruvate kinase
359
demethylase
358
ornithine decarboxylase
358
firefly luciferase
355
phosphoenolpyruvate carboxykinase
352
protein phosphatase 2A
350
diaphorase
349
xanthine oxidase
349
histidine kinase
337
beta-lactamase
335
citrate synthase
335
RNase H
332
MMP
326
aldehyde dehydrogenase
326
thymidylate synthase
325
heme oxygenase
325
cholinesterase
324
lipoxygenase
316
hypoxanthine-guanine phosphoribosyltransferase
315
phosphorylase
314
prostate-specific antigen
311
invertase
309
phosphoenolpyruvate carboxykinase
309
cellulase
309
alpha-amylase
307
carbonic anhydrase
307
deaminase
302
phosphoenolpyruvate carboxykinase
301
cathepsin D
292
chaperonin
291
proteinase K
290
subtilisin
290
sulfatase
290
lipoprotein lipase
289
papain
288
aldehyde dehydrogenase
287
tissue plasminogen activator
285
phospholipase D
285
plasmin
277
MEKK1
273
nitrate reductase
271
adenosine deaminase
271
DNA ligase
270
adenosine deaminase
269
neutrophil elastase
269
DNA ligase
269
nitrate reductase
268
nitrate reductase
267
nitrate reductase
267
nitrate reductase
267
nitrate reductase
267
furin
265
arginase
261
CYP3A4
257
cathepsin B
253
peroxiredoxin
252
MIP
249
aldehyde dehydrogenase
248
more...
Compound
DNA
81632
Dec
42591
oxygen
16027
water
14704
calcium
14693
glucose
11995
hydrogen
10349
ATP
10067
Cardiol
8638
phosphate
8132
sodium
8075
tyrosine
7793
Clin
7487
serine
6226
lysine
5927
cysteine
5868
arginine
5774
cAMP
5739
nitrogen
4991
salt
4753
iron
4709
alanine
4532
acetate
4313
nitric oxide
4183
zinc
4145
sulfate
4020
threonine
3826
His
3789
leucine
3760
TNF
3616
glutamate
3516
methionine
3498
SDS
3386
galactose
3129
copper
2980
Phe
2905
AMP
2897
ethanol
2877
MTT
2856
GTP
2809
potassium
2712
tryptophan
2596
urea
2472
ADP
2466
ADP
2353
ADP
2349
proline
2327
Asp
2188
GSH
2162
GSH
2160
PEG
2089
tryptophan
2066
tryptophan
1999
tryptophan
1999
Gly
1966
ammonium
1941
bromide
1873
retinoic acid
1847
MDA
1778
NAD
1777
glutamine
1770
iodine
1671
glycerol
1658
NH2
1609
H2O2
1606
silver
1585
pyrimidine
1559
vitamin D
1539
pyrimidine
1531
CO2
1416
NAD
1380
NADPH
1354
NADPH
1353
COS
1340
Mg2+
1321
Ile
1316
Insulin
1293
methanol
1241
manganese
1229
PEG
1222
MEK
1218
cGMP
1210
nitrate
1205
GABA
1202
GABA
1169
salicylic acid
1084
NADH
1082
BMC
1047
ammonia
1032
TOF
995
aldosterone
980
CoA
966
cadmium
954
nicotinamide
919
5-HT
912
benzene
912
valine
900
DMSO
859
asparagine
854
acetic acid
851
EDTA
849
EDTA
847
pyridine
844
glutamic acid
835
dUTP
814
phenol
805
Estrogen
790
GlcNAc
789
GDP
780
creatinine
772
uridine
772
nickel
768
COI
754
aspartic acid
740
ACTH
730
TEM
726
Estrogen
723
Cu(II)
719
aspartic acid
715
aldehyde
705
cobalt
698
GMP
697
isoleucine
688
N-acetylcysteine
677
NADP
675
THP
675
isoleucine
675
CAT
664
THP
663
CAT
655
CAT
655
aspartic acid
654
aspartic acid
653
Triton X-100
648
Histone
647
Vitamin D
646
PMA
645
caffeine
639
formaldehyde
632
HCl
629
homocysteine
624
pyrene
615
Neuronal
615
chloroform
612
boron
609
fluorine
607
phosphorus
589
TSH
589
DEAE
579
gamma-aminobutyric acid
577
aldehyde
572
cyanide
569
ADP-ribose
568
palmitic acid
552
adenosylmethionine
544
NMDA
541
ICI
539
selenium
532
carbonate
531
Ang II
530
more...