Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P06889 (Mol)
630,302 document(s) hit in 31,850,051 MEDLINE articles (0.25 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Mol 630302
Sep 39662
Gen 11089
ATP 10058
insulin 9134
cytokine 8422
NMR 6875
p53 6846
polypeptide 6575
histone 5882
endoplasmic reticulum 5777
collagen 5636
ATPase 4671
ubiquitin 4225
fused 4219
caspase-3 4112
lipopolysaccharide 3800
tumor necrosis factor 3754
tRNA 3679
TNF 3616
glycoprotein 3351
p38 3348
Pseudomonas 3306
proteasome 3294
SDS 3243
MAPK 3218
IL-6 3184
estrogen receptor 3066
superoxide dismutase 2981
Bcl-2 2950
tyrosine kinase 2855
gut 2854
AMP 2833
AKT 2804
ERK1 2763
ERK 2711
GTP 2706
mTOR 2655
phosphatase 2620
membrane protein 2582
interferon 2483
vascular endothelial growth factor 2482
catalase 2422
threonine 2410
PI3K 2363
p21 2348
ADP 2348
CD4 2261
epidermal growth factor receptor 2064
endonuclease 2038
UTR 2025
fibronectin 2016
dimeric 2010
lymphoid 2002
membrane-bound 1964
calmodulin 1964
myosin 1952
axonal 1942
RNA polymerase II 1933
GSH 1894
epidermal growth factor 1886
alkaline phosphatase 1877
catenin 1869
GTPase 1852
Rho 1845
chemokine 1809
telomeric 1778
serum albumin 1774
IFN 1763
androgen receptor 1752
cytochrome c 1739
hemoglobin 1736
lectin 1714
cryptic 1670
albumin 1656
CD8 1654
cytochrome P450 1638
reductase 1637
JNK 1616
LPS 1613
SOD 1604
matrix metalloproteinase 1586
extracellular signal-regulated kinase 1581
p65 1580
IL-8 1566
X-linked 1539
histone H3 1529
thymus 1513
IL-10 1505
cyclin D1 1498
erythroid 1487
glucocorticoid receptor 1465
nuclear receptor 1461
nitric oxide synthase 1448
DNase I 1428
AP-1 1427
c-Jun 1425
olfactory 1425
inducible nitric oxide synthase 1418
spermatozoa 1394
cyclin 1392
cytochrome 1388
NAD 1380
histone deacetylase 1354
NADPH 1353
angiotensin II 1342
MEK 1335
lactate dehydrogenase 1333
mitogen-activated protein 1330
growth hormone 1310
DNA-binding domain 1303
E-cadherin 1289
peroxidase 1284
PKC 1265
cytochrome b 1258
amyloid precursor protein 1254
phosphatidylinositol 3-kinase 1246
ROS 1241
RNase 1238
microsomal 1235
ras 1233
interleukin-6 1228
glutathione peroxidase 1226
EGFR 1220
G protein-coupled receptor 1219
methyltransferase 1218
leptin 1209
TNF-alpha 1204
zinc finger 1202
adenylate cyclase 1198
aromatase 1197
IL-4 1196
brain-derived neurotrophic factor 1195
VEGF 1193
prolactin 1190
TLR4 1189
osteogenic 1188
proliferating cell nuclear antigen 1179
c-fos 1172
helicase 1155
unknown function 1152
GABA 1148
transcriptional activator 1144
STAT3 1143
progesterone receptor 1117
major histocompatibility complex 1117
thyroid hormone 1113
vimentin 1108
kit 1096
NADH 1094
nuclear protein 1090
IgE 1089
MHC 1085
PARP 1071
RhoA 1056
cage 1049
adenylyl cyclase 1048
MAP kinase 1037
Sp1 1036
c-myc 1025
more...
Disease
cancer 46002
tumor 33353
breast cancer 8817
Alzheimer's disease 6481
diabetes 6177
tumorigenesis 5231
carcinoma 4868
tumor growth 4544
obesity 4374
ischemia 4297
hepatocellular carcinoma 4098
carcinogenesis 3813
prostate cancer 3784
HIV 3399
tumor progression 3394
cold 3308
SDS 3257
lung cancer 3235
leukemia 3113
Parkinson's disease 3068
colorectal cancer 2992
hypertension 2903
atherosclerosis 2826
adenocarcinoma 2774
melanoma 2735
depression 2553
asthma 2536
metastases 2530
stroke 2442
MCF 2373
type 2 diabetes 2358
heart failure 2334
glioma 2217
schizophrenia 2036
neuroblastoma 1950
infectious diseases 1949
GSH 1896
immunodeficiency 1880
malaria 1817
cardiovascular disease 1810
tuberculosis 1805
squamous cell carcinoma 1805
myocardial infarction 1798
Mycobacterium 1794
ovarian cancer 1790
lymphoma 1770
virus infection 1766
colon cancer 1719
gastric cancer 1712
autism 1695
plaque 1516
multiple sclerosis 1424
glioblastoma 1422
influenza 1410
uterus 1402
dementia 1394
cystic fibrosis 1388
rheumatoid arthritis 1369
sepsis 1325
amyotrophic lateral sclerosis 1312
pancreatic cancer 1312
Huntington's disease 1282
epilepsy 1276
sepsis 1245
non-small cell lung cancer 1183
herpes simplex 1150
pertussis 1143
osteoporosis 1127
acute myeloid leukemia 1122
hyperglycemia 1121
ATM 1106
multiple myeloma 1079
chronic obstructive pulmonary disease 1038
cognitive impairment 1033
retinoblastoma 1001
metabolic syndrome 991
renal cell carcinoma 977
cholera 976
osteosarcoma 969
infertility 957
coronary artery disease 950
autoimmune disease 935
systemic lupus erythematosus 926
cervical cancer 924
anemia 911
cardiomyopathy 909
myocardial ischemia 905
osteoarthritis 904
hepatitis B 893
arthritis 879
cerebral ischemia 876
cirrhosis 865
bladder cancer 806
hepatitis C 793
pheochromocytoma 784
lung disease 782
liver cancer 778
Duchenne muscular dystrophy 778
cytomegalovirus 772
pulmonary hypertension 767
West 762
Autism 760
liver disease 744
bipolar disorder 741
dehydration 740
B-cell lymphoma 739
inflammatory bowel disease 738
sarcoma 735
SEM 734
worms 734
Infection 729
fatty liver 728
pulmonary fibrosis 720
renal disease 716
fits 716
primary tumor 715
pneumonia 714
aggressiveness 703
Epstein 695
dysplasia 693
mental retardation 691
AIDS 685
heart disease 677
mental retardation 671
chronic myeloid leukemia 646
lung carcinoma 622
liver cancer 621
major depressive disorder 615
Blocking 609
mole 607
brain tumor 607
type 1 diabetes 602
liver fibrosis 597
muscular atrophy 595
glioblastoma multiforme 585
preeclampsia 584
blindness 584
Yersinia 575
colitis 572
endometrial cancer 562
mammary tumor 561
epithelial ovarian cancer 560
mole 559
genetic disorder 543
bacterial infection 542
SCID 538
suicide 533
myopathy 532
APC 529
acute lymphoblastic leukemia 525
Klebsiella 514
endometriosis 509
SARS 508
skin cancer 503
NAME 502
TEM 502
tumor angiogenesis 498
malnutrition 493
idiopathic pulmonary fibrosis 485
TEM 484
more...
Symptom
pain 3255
starvation 2103
seizures 1441
collapse 770
weakness 662
ataxia 573
respiratory distress 571
functional recovery 558
hyperoxia 548
anesthesia 516
diarrhea 516
fatigue 358
acidity 340
exhaustion 256
overweight 250
analgesia 249
tremor 244
hypotonia 237
hypothermia 221
thinning 217
cachexia 173
dystonia 170
acute stress 169
vomiting 145
headache 139
splenomegaly 136
abdominal pain 133
HSA 130
anorexia 128
memory loss 127
hypercapnia 123
masculinization 118
spasticity 116
stigma 115
cough 114
angina 112
cerebellar ataxia 110
hepatomegaly 107
DNA marker 100
nausea 96
agitation 96
Neuropathic pain 96
twitching 95
insomnia 89
dyspnea 85
constipation 81
discomfort 81
dry eye 77
discomfort 75
hepatosplenomegaly 73
bone pain 69
ophthalmoplegia 66
erythema 65
chills 59
low back pain 58
back pain 58
bitter taste 58
lethargy 55
fasciculation 52
acute pain 51
skin damage 51
syncope 48
hunger 48
bradykinesia 46
flushing 46
chest pain 46
pelvic pain 45
arthralgia 45
myoclonus 44
eds 44
myalgia 44
neurological disability 43
wheezing 41
despair 39
nausea and vomiting 38
Hudson 37
Ill 36
anosmia 35
dysarthria 33
general problem 32
regurgitation 31
cancer pain 31
menopausal symptoms 30
CSR 30
Scratch 30
spasm 28
dizziness 28
shortness of breath 27
sleepiness 27
apathy 26
polyuria 25
vertigo 25
Wind 25
incoordination 24
rundown 24
tinnitus 23
abnormal gait 23
fever of unknown origin 23
microbial colonization 23
Anoxia 22
distraction 22
muscle stiffness 20
POA 20
Stiffness 20
chorea 20
paresis 18
sore throat 18
cyanosis 18
bloating 17
exertional dyspnea 17
tense 17
hypertonia 16
tachypnea 16
numbness 16
autodigestion 16
dry skin 16
rigors 15
Depressive symptoms 15
pallor 15
sneezing 15
male subfertility 15
Halo 15
Spots 15
physical appearance 14
hot flushes 14
paraparesis 14
Fluctuation 14
photophobia 13
muscle rigidity 13
epigastric pain 13
ACHE 13
hemoptysis 13
orofacial pain 13
disturbed balance 12
joint stiffness 12
ataxic gait 12
paresthesia 12
skin irritation 12
polydipsia 12
Decreased activity 12
rhinorrhea 11
loss of equilibrium 10
abdominal discomfort 10
hemiplegia 10
hot flashes 10
dental pain 9
stridor 9
asthenia 9
nasal congestion 9
female puberty 9
hoarseness 9
sciatica 9
intention tremor 8
muscle cramps 8
impaired motor coordination 8
urinary frequency 8
catatonia 8
Hyperekplexia 8
ketonuria 8
heartburn 8
more...
Drug
lysine 4511
Mutagen 2811
DNase I 1447
ROS 1241
NADH 1085
Gel 1040
MAP 891
IFN-gamma 827
Asn 790
ascorbate 767
IL-2 759
CSF 731
caffeine 634
Leaf 591
ABC 561
vitamin E 551
ICI 492
lactose 483
Glutathione 379
EE2 369
Angiotensin II 343
FAD 340
p75 289
ETS 274
G418 272
Capsicum 241
citric acid 241
Ethanol 241
Heme 238
Asthma 238
Forskolin 234
THF 233
Estrogens 230
CAM 228
ZnO 227
Retinoic acid 223
Parkin 222
Parkin 222
Alanine 222
PTH 218
CTX 211
ROC 210
Fragment 203
ampicillin 201
Activin 194
CaCl2 194
TAT 190
TiO2 188
Nephron 188
CaCl2 188
CaCl2 188
DM1 185
Taxol 185
nitroglycerin 163
Albumin 154
DHT 148
Adriamycin 147
DHT 146
NH3 145
Growth hormone 143
Growth hormone 140
Glucagon 140
AraC 136
Herceptin 134
uPA 134
BH4 133
Kenyan 132
G-CSF 129
Spectrum 125
ALA 123
BLM 123
Imatinib 121
Histamine 121
Vitamin E 120
GEO 118
pyridoxal phosphate 117
TTC 117
Indomethacin 117
IFN-beta 115
Vitamin A 114
CTX 112
CTX 111
MRC 110
Simvastatin 109
EPA 109
ETA 107
Sorafenib 104
Ouabain 102
L-tyrosine 99
Bifidobacterium 99
Spectrum 98
Glide 98
AGG 98
ADM 97
R1881 97
niacin 96
Bortezomib 95
FLP 94
NAG 94
Paraffin 93
ADR 91
CDP 91
Fluorescein 89
Amiloride 88
PCP 85
RFP 85
Allergen 82
Portal 81
Arsenic trioxide 80
Amiloride 80
Gefitinib 79
SiO2 78
ENT 77
Itraconazole 77
HCH 77
CoCl2 77
CoCl2 77
NVP 76
IL-1ra 76
CCL 75
ACT 75
Glycerol 75
TAC 72
AZT 71
AZT 71
Docetaxel 70
Biopolymers 70
Fructose 70
-deoxyadenosine 69
Gleevec 68
DEX 68
PTC 65
TAK 65
Gelatin 63
Bevacizumab 61
Fluorescein 60
Luteinizing 60
Cetuximab 59
CPT-11 59
AMC 58
VCR 57
Fraction 57
PCB 56
Propofol 56
Coral 55
Captopril 54
Ranitidine 53
CTC 53
Vitamin K 52
IL-11 51
ZnCl2 51
ZnCl2 51
Oxaliplatin 51
Carotenoid 50
MOF 49
Emodin 49
Silica 49
NBT 49
Rosiglitazone 49
Emodin 48
more...
Enzyme
mitogen-activated protein kinase 11016
protein kinase 9771
ERK 7521
RNA polymerase 5325
luciferase 5138
ATPase 4932
protein kinase C 4123
superoxide dismutase 3496
proteasome 3420
caspase-3 3217
catalase 3041
focal adhesion kinase 2948
reverse transcriptase 2344
trypsin 2164
peroxidase 2095
endonuclease 2039
MEK 2007
RNase 1930
alkaline phosphatase 1891
RNase 1843
glutathione S-transferase 1722
calcineurin 1633
DNA polymerase 1503
phospholipase C 1430
lactate dehydrogenase 1393
beta-galactosidase 1359
AMP-activated protein kinase 1347
PARP 1340
adenylate cyclase 1257
glutathione peroxidase 1252
phosphatidylinositol 3-kinase 1252
AMPK 1171
cdc2 1107
phosphodiesterase 1073
renin 1006
lysozyme 978
thrombin 954
topoisomerase 949
collagenase 924
topoisomerase 884
acetylcholinesterase 869
complex I 866
thymidine kinase 850
chloramphenicol acetyltransferase 837
NADPH oxidase 810
aspartate aminotransferase 791
P-glycoprotein 767
alanine aminotransferase 763
cytochrome oxidase 759
NADPH oxidase 753
creatine kinase 745
GSK 743
NO synthase 740
tyrosine hydroxylase 723
phospholipase A2 709
APC 704
lipase 699
beta-glucuronidase 695
DNase 662
caspase-9 657
dihydrofolate reductase 638
AMPK 637
ribonuclease 629
ribonuclease 629
transcriptase 628
glyceraldehyde-3-phosphate dehydrogenase 626
phosphoinositide 3-kinase 621
ATP synthase 615
caspase-8 602
chymotrypsin 587
IKK 564
S1 nuclease 561
DNA methyltransferase 555
guanylate cyclase 531
kinesin 529
ACE 517
glutathione reductase 512
urokinase-type plasminogen activator 511
alcohol dehydrogenase 498
glyceraldehyde-3-phosphate dehydrogenase 497
acid phosphatase 482
neuraminidase 480
histone acetyltransferase 475
elastase 451
tyrosinase 451
MAP 448
caspase-1 445
NOS 440
succinate dehydrogenase 437
CD10 425
glyceraldehyde-3-phosphate dehydrogenase 413
chitinase 401
CaMKII 388
glutamine synthetase 387
glyceraldehyde-3-phosphate dehydrogenase 384
glyceraldehyde-3-phosphate dehydrogenase 383
micrococcal nuclease 378
glucose-6-phosphate dehydrogenase 372
HSD 371
pyruvate dehydrogenase 369
NQO1 361
hexokinase 361
pyruvate kinase 359
demethylase 358
ornithine decarboxylase 358
firefly luciferase 355
phosphoenolpyruvate carboxykinase 352
protein phosphatase 2A 350
diaphorase 349
xanthine oxidase 349
histidine kinase 337
beta-lactamase 335
citrate synthase 335
RNase H 332
MMP 326
aldehyde dehydrogenase 326
thymidylate synthase 325
heme oxygenase 325
cholinesterase 324
lipoxygenase 316
hypoxanthine-guanine phosphoribosyltransferase 315
phosphorylase 314
prostate-specific antigen 311
invertase 309
phosphoenolpyruvate carboxykinase 309
cellulase 309
alpha-amylase 307
carbonic anhydrase 307
deaminase 302
phosphoenolpyruvate carboxykinase 301
cathepsin D 292
chaperonin 291
proteinase K 290
subtilisin 290
sulfatase 290
lipoprotein lipase 289
papain 288
aldehyde dehydrogenase 287
tissue plasminogen activator 285
phospholipase D 285
plasmin 277
MEKK1 273
nitrate reductase 271
adenosine deaminase 271
DNA ligase 270
adenosine deaminase 269
neutrophil elastase 269
DNA ligase 269
nitrate reductase 268
nitrate reductase 267
nitrate reductase 267
nitrate reductase 267
nitrate reductase 267
furin 265
arginase 261
CYP3A4 257
cathepsin B 253
peroxiredoxin 252
MIP 249
aldehyde dehydrogenase 248
more...
Compound
DNA 81632
Dec 42591
oxygen 16027
water 14704
calcium 14693
glucose 11995
hydrogen 10349
ATP 10067
Cardiol 8638
phosphate 8132
sodium 8075
tyrosine 7793
Clin 7487
serine 6226
lysine 5927
cysteine 5868
arginine 5774
cAMP 5739
nitrogen 4991
salt 4753
iron 4709
alanine 4532
acetate 4313
nitric oxide 4183
zinc 4145
sulfate 4020
threonine 3826
His 3789
leucine 3760
TNF 3616
glutamate 3516
methionine 3498
SDS 3386
galactose 3129
copper 2980
Phe 2905
AMP 2897
ethanol 2877
MTT 2856
GTP 2809
potassium 2712
tryptophan 2596
urea 2472
ADP 2466
ADP 2353
ADP 2349
proline 2327
Asp 2188
GSH 2162
GSH 2160
PEG 2089
tryptophan 2066
tryptophan 1999
tryptophan 1999
Gly 1966
ammonium 1941
bromide 1873
retinoic acid 1847
MDA 1778
NAD 1777
glutamine 1770
iodine 1671
glycerol 1658
NH2 1609
H2O2 1606
silver 1585
pyrimidine 1559
vitamin D 1539
pyrimidine 1531
CO2 1416
NAD 1380
NADPH 1354
NADPH 1353
COS 1340
Mg2+ 1321
Ile 1316
Insulin 1293
methanol 1241
manganese 1229
PEG 1222
MEK 1218
cGMP 1210
nitrate 1205
GABA 1202
GABA 1169
salicylic acid 1084
NADH 1082
BMC 1047
ammonia 1032
TOF 995
aldosterone 980
CoA 966
cadmium 954
nicotinamide 919
5-HT 912
benzene 912
valine 900
DMSO 859
asparagine 854
acetic acid 851
EDTA 849
EDTA 847
pyridine 844
glutamic acid 835
dUTP 814
phenol 805
Estrogen 790
GlcNAc 789
GDP 780
creatinine 772
uridine 772
nickel 768
COI 754
aspartic acid 740
ACTH 730
TEM 726
Estrogen 723
Cu(II) 719
aspartic acid 715
aldehyde 705
cobalt 698
GMP 697
isoleucine 688
N-acetylcysteine 677
NADP 675
THP 675
isoleucine 675
CAT 664
THP 663
CAT 655
CAT 655
aspartic acid 654
aspartic acid 653
Triton X-100 648
Histone 647
Vitamin D 646
PMA 645
caffeine 639
formaldehyde 632
HCl 629
homocysteine 624
pyrene 615
Neuronal 615
chloroform 612
boron 609
fluorine 607
phosphorus 589
TSH 589
DEAE 579
gamma-aminobutyric acid 577
aldehyde 572
cyanide 569
ADP-ribose 568
palmitic acid 552
adenosylmethionine 544
NMDA 541
ICI 539
selenium 532
carbonate 531
Ang II 530
more...