Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P06889 (
Mol
)
630,302
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The three mitochondrial-encoded proteins, COX1, COX2, and COX3, form the core of the cytochrome c oxidase. Upon synthesis, COX2 engages with COX20 in the inner mitochondrial membrane, a scaffold protein that recruits metallochaperones for copper delivery to the Cu
A
-Site of COX2. Here we identified the human protein,
TMEM177
as a constituent of the COX20 interaction network. Loss or increase in the amount of
TMEM177
affects COX20 abundance leading to reduced or increased COX20 levels respectively.
TMEM177
associates with newly synthesized COX2 and SCO2 in a COX20-dependent manner. Our data shows that by unbalancing the amount of
TMEM177
, newly synthesized COX2 accumulates in a COX20-associated state. We conclude that
TMEM177
promotes assembly of COX2 at the level of Cu
A
-site formation.
Biochim Biophys Acta
Mol
Cell Res 2018 Feb
PMID:The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. 2915 48
