Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P06889 (Mol)
 630,302 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)


Virchows Arch B Cell Pathol Incl Mol Pathol 1979 Dec
PMID:The ploidy classes of adult mouse liver cells. A methodological study with flow cytometry and cell sorting. 9 37


Exp Mol Pathol 1978 Dec
PMID:Diabetic microangiopathy in KK mice. V. Effect of early glyburide treatment of kidney glucosyltransferase activity. 10 28

The replication in Bacillus subtilis of the staphylococcal R plasmids pE194, pBD15, pUB110, pSA0501, and pSA2100 has been studied in the presence of hydroxyurea. In all cases, an enrichment for covalently closed circular DNA compared with chromosomal DNA was observed. In this respect, hydroxyurea mimics the effect previously observed with pUB110, using strains carrying the conditional mutation dnaA13. This mutation has been reported to affect ribonucleotide reductase (G. W. Bazill and D. Karamata, Mol. Gen. Genet. 117:19-29, 1972). An explanation for these effects is offered, together with some supporting evidence.
J Bacteriol 1978 Dec
PMID:Differential effect of hydroxyurea on the replication of plasmid and chromosomal DNA in Bacillus subtilis. 10 36

1. The capacity of various tissues of the porcine kidney to convert [1-14C]arachidonic acid into radiolabelled prostaglandins was studied. 2. Only after removal from the cortical matrix, were renal blood vessels able to convert arachidonic acid into prostaglandins (primarily prostacyclin). In contrast, convoluted tubules showed a low capacity to metabolize arachidonic acid. 3. The failure to demonstrate prostaglandin synthesis by renal cortical slices is related to the presence of an inhibitor of cyclo-oxygenase. Thus the addition of renal cortical incubate to isolated vascular tissues and ram seminal vesicles inhibited their ability to synthesize prostaglandins. 4. Slices of renal medulla metabolized arachidonic acid primarily to prostaglandin F2alpha; lesser amounts of prostaglandin E2 and prostacyclin were generated. 5. The large capacity of the renal vasculature to generate prostacyclin is consistent with an important role for this prostaglandin in regulation of renin release and renal haemodynamics.
Clin Sci Mol Med Suppl 1978 Dec
PMID:Endogenous prostaglandin synthesis inhibitor in the renal cortex. Effects on production of prostacyclin by renal blood vessels. 10 75


J Mol Biol 1978 Dec 05
PMID:Similarities in active center geometries of zinc-containing enzymes, proteases and dehydrogenases. 10 46


J Mol Biol 1978 Dec 25
PMID:Ribosomal DNA in Drosophila melanogaster. I. Isolation and characterization of cloned fragments. 10 28


J Mol Biol 1978 Dec 25
PMID:Ribosomal DNA in Drosophila melanogaster. II. Heteroduplex mapping of cloned and uncloned rDNA. 10 29

Autoantibodies to the insulin receptor mimic the effects of insulin on glycogen synthase and phosphorylase. The interaction of antibodies with adipocyte cell surface insulin receptors seems sufficient to promote stable changes in the activities of these intracellular enzymes, suggesting that internalization or processing of insulin is not important in the generation of these biological responses.
Mol Cell Biochem 1978 Dec 22
PMID:Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes. 10 36


Exp Mol Pathol 1979 Dec
PMID:Atherosclerotic plaque regression in rhesus monkeys induced by bile acid sequestrant. 11 68

Glucose stimulates the uptake of 45Ca into beta-cell-rich pancreatic islets isolated from ob/ob-mice. The distribution of the incorporated radioactivity was analysed by labelling the organelles with 45Ca in their cellular environment. The radioactive content of the organelles was measured after homogenization and fractionation of the islets under conditions preventing 45Ca redistribution. The 45Ca taken up in response to glucose appeared essentially in the secretory granule fraction and in that enriched in mitochondria. Modification of the 45Ca loading procedure, involving reduction of the oxygen tension and incubation volume, resulted in the disappearance of the glucose effect on the mitochondrial fraction whereas part of the stimulatory effect on the secretory granules persisted. Buffering of calcium by the secretory granules and mitochondria may be important for regulating the cytoplasmic Ca2+ involved in stimulus-secretion coupling.
Mol Cell Endocrinol 1979 Dec
PMID:Calcium and pancreatic beta-cell function. 6. Glucose and intracellular 45Ca distribution. 11 64


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