Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P06889 (Mol)
 630,302 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. By substituting one anti-hypertensive drug for the other in a panel of hypertensive patients equipotent doses have been determined. 2. Thus 40 mg of propranolol is equivalent to 4-5 mg of pindolol, 98 mg of practolol, 128 mg of alprenolol, 49 mg of metoprolol, 42 mg of tolamolol and 4-4 mg of timolol. 3. Bendorfluazide (10 mg) is eqivalent to 1-6 mg of bumetanide, 20 mg of chlorthalidone, 35 mg of mefruside and 3-5 mg of amiloride together with 35 mg of hydrochlorthiazide. 4. Methyldopa (250 mg) is equivalent to 6-0 mg of debrisoquine and 0-5 mg of St 600 (Boehringer), which is a clonidine-like substituted imidazoline.
Clin Sci Mol Med Suppl 1976 Dec
PMID:Within-patient comparisons between different anti-hypertensive drugs. 1 61

1. Nine men aged 20-33 years with essential hypertension measured their own blood pressure at home, lying and standing, three times daily, under conditions of everyday living. The last 14 days' readings (eighty-four observations) from control and treatment periods of at least 4 weeks' duration were used to calculate mean pressures. 2. In eight patients, propranolol (40 mg thrice daily with meals) significantly lowered "mean blood pressure" (diastolic+1/3[systolic-diastolic]) but methyclothiazide (5 mg with breakfast) did not. In five subjects, prindolol (5 mg thrice daily with meals) significantly lowered "mean blood pressure" but methyclothiazide (5 mg with breakfast) did not. 3. In six subjects there was no significant difference between "mean blood pressure" when taking propranolol doses 120 mg with breakfast, 60 mg with breakfast and with the evening meal, and 40 mg with each meal. In five subjects there was no significant difference between "mean blood pressure" when taking metoprolol 200 mg with breakfast and 100 mg with breakfast and with the evening meal. In four subjects there was no significant difference between "mean blood pressure" when taking prindolol 30 mg with breakfast, 15 mg with breakfast and with the evening meal, and 10 mg with each meal. 4. In young males with essential hypertension, beta-adrenoreceptor blockers were more effective than a thiazide diuretic in lowering blood pressure, and were effective in a single daily dose.
Clin Sci Mol Med Suppl 1976 Dec
PMID:Initial treatment of the young hypertensive: thiazide diuretic or beta-adrenoreceptor-blocking agent in a single daily dose? 1 62

1. The morphology of the juxtaglomerular apparatus, plasma renin activity, plasma renin substrate and renal renin have been studied in rats after maximal stimulation by bilateral adrenalectomy and salt depletion, and also after blocking this stimulation by deoxycorticosterone and salt load. 2. After stimulation the juxtaglomerular apparatus showed a well-developed granular endoplasmic reticulum and a low secretory granule content. Plasma renin activity was markedly elevated and plasma renin substrate was low. After blockade numerous specific granules with crystalline structures were seen and the granular endoplasmic reticulum was less developed. Plasma renin activity was now low and plasma renin substrate elevated. 3. After prior acidification of the kidney extract a significant increase of renal renin was observed in both conditions but was greater in the second group at the time when large numbers of young granules containing crystalline material were seen. 4. Kidney slices from the adrenalectomized salt-depleted rats released more renin than control slices. Vincristine did not affect this release, but inhibited release from slices stimulated by isoprenaline.
Clin Sci Mol Med Suppl 1976 Dec
PMID:Control of renin secretion in vivo and in vitro in rats: arguments in favour of a precursor form of renin and of a role of a microtubular system. 1 63


Clin Sci Mol Med 1977 Dec
PMID:Abnormalities in enzymes involved in catecholamine synthesis and catabolism in phaeochromocytoma. 2 22


Clin Sci Mol Med 1977 Dec
PMID:Increase in serum ionized calcium during exercise. 2 23


J Mol Biol 1977 Dec 25
PMID:Regulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli. I. Isolation and characterization of a mutant with elevated levels of tRNAGln 1. 2 22


J Mol Biol 1977 Dec 25
PMID:Preliminary crystallographic studies on quinolinate phosphoribosyltransferase. 2 23

3-Hydroxykynureninase was purified from rat liver. The Michaelis constants for L-kynurenine and L-3-hydroxykynurenine were determined to be 2.33 X 10(-4)M and 6.85 X 10(-5)M, respectively, at pH 8.41 and 37 degrees. With L-kynurenine as substrate, the enzyme was competitively inhibited by L-alanine, 3-hydroxyanthranilic acid, and several other compounds which contained structural features of either amino acid or aryl portions of the substrate. The effect of pH on the initial velocity, maximal velocity, and Michaelis constant, using L-kynurenine as substrate, was studied. Maximal velocity was strongly pH-dependent, with a maximum at pH 8.4. The Michaelis constant decreased from 11.4 X 10(-4)M at pH 7.1 to 1.30 X 10(-4)M at pH 9.0. Logarithmic plots of these data showed pKa's for functional groups ionizing in the enzyme-substrate complex and free enzyme active center of 7.6 and 8.5, respectively. Possible groups responsible for these ionizations were discussed.
Mol Cell Biochem 1977 Dec 29
PMID:Kinetic studies on 3-hydroxykynureninase from rat liver. 2 71


J Mol Biol 1977 Dec 15
PMID:Endo R DpnI restriction of Escherichia coli DNA synthesized in vitro. Evidence that the ends of Okazaki pieces are determined by template deoxynucleotide sequence. 2 49


Clin Sci Mol Med Suppl 1978 Dec
PMID:Proceedings of the Fifth Meeting of the International Society of Hypertension, Paris, 12-14 June 1978. 3 98


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>