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Query: UNIPROT:P06889 (Mol)
 630,302 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Triphenyl phosphine adducts of dithiocarbamate complexes of platinum(IV) and palladium(II) of the type [Pt(L)2PPh3Cl2] and [Pd(L)2PPh3] [L: morpholine dithiocarbamate (L1), aniline dithiocarbamate (L2) and N-(methyl, cyclohexyl) dithiocarbamate (L3)] were prepared and characterized by elemental analysis, electronic, IR, 1H NMR and 13C NMR spectral studies. Thermal studies of the complexes were carried out. In vitro antitumor activity has been screened towards human adenocarcinoma cell lines and showed significant inhibition even at very low concentration.
Spectrochim Acta A Mol Biomol Spectrosc 2004 Nov
PMID:Triphenyl phosphine adducts of platinum(IV) and palladium(II) dithiocarbamates complexes: a spectral and in vitro study. 1547 48

Phytoplasmas are cell wall-less bacteria inhabiting the phloem and utilizing it for their spread. Infected plants often show changes in growth pattern and a reduced crop yield. A quantitative real-time polymerase chain reaction (Q-PCR) assay and a bioimaging method were developed to quantify and localize phytoplasmas in situ. According to the Q-PCR assay, phytoplasmas accumulated disproportionately in source leaves of Euphorbia pulcherrima and, to a lesser extent, in petioles of source leaves and in stems. However, phytoplasma accumulation was small or nondetectable in sink organs (roots and sink leaves). For bioimaging, infected plant tissue was stained with vital fluorescence dyes and examined using confocal laser scanning microscopy. With a DNA-sensitive dye, the pathogens were detected exclusively in the phloem, where they formed dense masses in sieve tubes of Catharanthus roseus. Sieve tubes were identified by counterstaining with aniline blue for callose and multiphoton excitation. With a potentiometric dye, not all DNA-positive material was stained, suggesting that the dye stained metabolically active phytoplasmas only. Some highly infected sieve tubes contained phytoplasmas that were either inactive or dead upon staining.
Mol Plant Microbe Interact 2004 Nov
PMID:Distribution of phytoplasmas in infected plants as revealed by real-time PCR and bioimaging. 1555 43

Using Density Functional Theory, the hydrogen bonding energy is calculated for the interaction of phenol and aniline with four model compounds representing the protein backbone and various amino acid side chain residues. The models are methanol, protonated methylamine, formaldehyde and acetate anion. The H-bond energies for the uncharged species are approximately 2.5 kcal mol(-1), whereas the charged model compounds bind with much higher energies of approximately 20 kcal mol(-1). The effect of para-substitution on the hydrogen bond energies is determined. Substitution has little effect on the H-bond energy of the neutral complexes (<2 kcal mol(-1)), but for the positively and negatively charged systems substitution drastically alters the binding energies, e.g., 14.3 kcal mol(-1) for para-NO2. In the context of protein-ligand binding, relatively small changes in binding energy can cause large changes in affinity due to their exponential relationship. This means that for -NO2 an enormous change of 10 orders of magnitude for the affinity constant is predicted. These calculations allow prediction of H-bonds, using different substituents, in order to fine-tune and optimize ligand-protein interactions in the search for drug candidates.
J Comput Aided Mol Des 2004 Jun
PMID:Tuning of hydrogen bond strength using substituents on phenol and aniline: a possible ligand design strategy. 1566 2

The FTIR and FT-Raman spectra of 2,6-dibromo-4-nitroaniline (2,6-DB4NA) in solid phase and 2-(methylthio)aniline (2-MTA) in liquid phase were measured. The geometry and normal vibrations have been obtained from the density functional theory (DFT) with the B3LYP method employing the 6-31G* basis set. Scale factors, which bring computational frequencies in closer agreement with the experimental data, have been calculated for predominant vibrational motions of the normal modes. The effects of the amino, bromine, nitro, thio and methyl substituents on vibrational frequencies have been investigated. The infrared and Raman spectra were also predicted from the calculated intensities. The observed and the calculated spectra were found to be in good agreement.
Spectrochim Acta A Mol Biomol Spectrosc 2005 Jun
PMID:FTIR and FT-Raman spectra, vibrational assignments and density functional theory calculations of 2,6-dibromo-4-nitroaniline and 2-(methylthio)aniline. 1586 52

A series of copper(II) complexes (CuL2x) with new N-di-methylphenyl-3,5-Bu2t-salicylaldimines (L(x)H) were prepared and characterized by IR, UV/vis, 1H NMR, ESR, cyclic voltammetry techniques and chemical oxidation. L(x)H ligands have been found selectively bind to a Cu(II), rather than to Ni(II), Co(II), Mn(II), VO(IV), Zn(II) and Cd(II). ESR examinations of the CuL2x complexes demonstrate that they exist in magnetically diluted mononuclear or coupled triplet-state structures in the solid. The temperature dependent (113-283 K) intensity of the powder ESR spectra for some CuL2x is characteristic of ferromagnetic coupling (J > 0). The reduction potentials of CuL2x in DMSO are sensitive to aniline moieties. Chemical oxidation of CuL2x with (NH4)2[Ce(NO3)6] in CHCl3 and MeCN solutions at 300 K affords gradually disappearance of their ESR signals and dramatic changes in the electronic spectra as well as the appearance of new maximum bands at 530-672 (CHCl3) and 670-700 nm (MeCN), suggesting generation of Cu(II)-phenoxyl radical species.
Spectrochim Acta A Mol Biomol Spectrosc 2006 Feb
PMID:Synthesis, spectroscopic and redox properties of the copper(II) complexes of N-(di-methylphenyl)-3,5-Bu2t-salicylaldimines. 1597 60

Some new organotin(IV) complexes with salicylaldehyde aniline-N-thiohydrazone (L1) and cinamaldehyde aniline-N-thiohydrazone (L2) of the type (p-ClC6H4)3Sn[L] Cl and (p-ClC6H4)2Sn[L]Cl2 have been synthesized (where L = L1 and L2). The complexes and ligands were characterized by elemental analysis and spectral (UV-vis, IR and 1H NMR) studies. In all the complexes, ligands act as bidentate, coordination through sulphur and azomethane nitrogen. Complexes are 1:1 metal ligands complexes. Antifungal studies of some complexes against Rhizoctonia bataticola fungal strain have been carried out.
Spectrochim Acta A Mol Biomol Spectrosc 2005 Oct
PMID:Organotin(IV) complexes of thiohydrazones: synthesis, characterization and antifungal study. 1616 58

A series of new mixed ligand hexacoordinated ruthenium(III) Schiff base complexes of the type [RuX(2)(EPh(3))(2)(LL')] (X=Cl, E=P; X=Cl or Br, E=As and LL'=anion of the Schiff bases derived from the condensation of 2-hydroxy-1-naphthaldehyde with aniline, 4-chloroaniline, 2-methyl aniline and 4-methoxy aniline) are reported. All the complexes have been characterized by analytical and spectral (IR, electronic and EPR) data. The redox behavior of the complexes has also been studied. The complexes exhibit catalytic activity in the oxidation of benzyl alcohol to benzaldehyde in the presence of N-methyl morpholine-N-oxide (NMO). An octahedral structure has been proposed for all of the complexes.
Spectrochim Acta A Mol Biomol Spectrosc 2006 Jul
PMID:Spectral, redox and catalytic studies of triphenylphosphine/triphenylarsine complexes of Ru(III) with N, O donor ligands derived from 2-hydroxy-1-naphthaldehyde and primary amines. 1633 Feb 48

Sixteen Schiff bases obtained from the condensation of benzaldehyde or salicylaldehyde with various amines (aniline, 4-carboxyaniline, phenylhydrazine, 2,4-dinitrophenylhydrazine, ethylenediamine, hydrazine, o-phenylenediamine and 2,6-pyridinediamine) are studied with UV-vis spectroscopy to observe the effect of solvents, substituents and other structural factors on the spectra. The bands involving different electronic transitions are interpreted. Computerized analysis and multiple regression techniques were applied to calculate the regression and correlation coefficients based on the equation that relates peak position lambda(max) to the solvent parameters that depend on the H-bonding ability, refractive index and dielectric constant of solvents.
Spectrochim Acta A Mol Biomol Spectrosc 2006 Feb
PMID:Spectral regression and correlation coefficients of some benzaldimines and salicylaldimines in different solvents. 1640 86

A few Pt(IV) complexes of the type [Pt(L)(2)Cl(2)] [where L=morpholine dithiocarbamate (L(1)), aniline dithiocarbamate (L(2)), N-(methyl, cyclohexyl) dithiocarbamate (L(3)) and N-(ethyl, cyclohexyl) dithiocarbamate (L(4))] were synthesized. The complexes have been characterized by elemental analysis, molar conductance, IR, electronic, (1)H and (13)C NMR spectroscopic studies. The ligands found to act in monobasic bidentate fashion. Cyclicvoltammetric studies, antibacterial and in vitro antitumour studies were also carried out.
Spectrochim Acta A Mol Biomol Spectrosc 2006 Sep
PMID:In vitro antitumour and antibacterial studies of some Pt(IV) dithiocarbamate complexes. 1652 76

Arylamine N-acetyltransferases (NATs) are xenobiotic-metabolizing enzymes involved in the detoxification of numerous aromatic chemicals. The NAT-dependent N-acetylation pathway has not previously been detected in plants. We demonstrate here the occurrence of the NAT-dependent pathway in leguminous plants, due to symbiosis with Mesorhizobium loti. We cloned two NAT enzymes from M. loti and showed that these two recombinant enzymes catalysed the N-acetylation of several known NAT substrates, including aniline-derived pesticide residues. We also demonstrate the existence of a functional NAT-dependent acetylation pathway in the root nodules of Lotus japonicus inoculated with M. loti. M. loti is the first non-eukaryotic organism shown to express two catalytically active NAT isoforms. This work also provides the first evidence for acquisition of a xenobiotic detoxification pathway by a plant through symbiosis with a soil microbe.
Mol Microbiol 2006 Apr
PMID:Cloning, functional expression and characterization of Mesorhizobium loti arylamine N-acetyltransferases: rhizobial symbiosis supplies leguminous plants with the xenobiotic N-acetylation pathway. 1657 98


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