Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P06889 (Mol)
 630,302 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)


J Mol Biol 1977 Sep
PMID:Co-operative mutagenic actions of bisulfite and nitrogen nucleophiles. 2 69


J Mol Biol 1977 Sep 15
PMID:Thermodynamics of gelation of sickle cell deoxyhemoglobin. 2 59


J Mol Biol 1977 Sep 25
PMID:Catalysis of DNA reassociation by the Escherichia coli DNA binding protein: A polyamine-dependent reaction. 2 60

1. Spiral strips of human digital arteries have been studied in vitro to investigate whether DL-propranolol, D-propranolol, oxprenolol and labetalol have peripheral vascular effects in man. 2. Labetalol was a potent inhibitor of contractile responses to noradrenaline, but had less effect on responses to 5-hydroxytryptamine and barium chloride. 3. DL-and D-propranolol were equally effective inhibitors of responses to barium chloride. They were only weak antagonists of noradrenaline responses, but stronger, non-competitive antagonists of 5-hydroxytryptamine responses. 4. Oxprenolol was only a weak inhibitor of the responses to both noradrenaline and 5-hydroxytryptamine and had little effect on responses to barium chloride. 5. It is concluded that labetalol has specific alpha-adrenoreceptor-blocking properties, which are probably relevant to its therapeutic action in man. Propranolol has non-specific inhibitory effect on vascular smooth muscle, which might contribute to its hypotensive activity at high concentrations, but oxprenolol has only slight peripheral effects that are probably therapeutically insignificant.
Clin Sci Mol Med 1978 Sep
PMID:Effects of the beta-receptor antagonists propranolol, oxprenolol and labetalol on human vascular smooth-muscle contraction. 2 41


J Mol Biol 1978 Sep 05
PMID:Thermodynamics of ligand binding and allosteric transition in hemoglobins. Reaction of Hb trout IV with CO. 3 Aug 44


Mol Pharmacol 1978 Sep
PMID:Comparative binding studies with cholinergic ligands and histrionicotoxin at muscarinic receptors of neural cell lines. 3 Aug 89


Mol Pharmacol 1978 Sep
PMID:Adenylate cyclase from Fasciola hepatica. 2. Role of guanine nucleotides in coupling adenylate cyclase and serotonin receptors. 3 Aug 90


Mol Pharmacol 1978 Sep
PMID:Methadone uptake by L5178Y mouse leukemic cells. 3 Aug 91


Mol Pharmacol 1978 Sep
PMID:Experimental observation of ionic forces in drug-protein interactions as illustrated by the binding of sulfaethidole by human serum albumin. 3 Aug 92


Mol Cell Endocrinol 1978 Sep
PMID:Properties of LH-sensitive adenylate cyclase in purified plasma membranes from rat ovary. 3 12


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