Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P06889 (Mol)
 630,302 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. A 25% faecal suspension in sodium chloride solution, incubated anaerobically at 37 degrees C for 48 h, showed excellent survival of all the main groups of faecal bacteria. 2. All faecal incubation systems studied generated large amounts of ammonia, particularly those in which bacterial counts fell during incubation. As normal faeces contain negligible amounts of urea this ammonia must have been generated from sources other than urea. 3. Ammonia was also generated by faeces delivered by sodium chloride enema, and by ileostomy fluid, indicating that the phenomenon is not confined to distal colonic contents. 4. Ammonia generation by incubated faeces was inhibited by prior autoclaving of the sample, but not by sterilization with gamma-irradiation. 5. Generation of ammonia by incubated stool was accompanied by release of large amounts of organic anion and a fall in pH. 6. These observations are interpreted as evidence that ammonia generated within the colon in situ is not derived exclusively from urea, but also from bacterial deamination of amino acids, peptides and proteins. Simultaneously bacterial activity generates large amounts of organacid. The presence of living bacteria is not essential for ammonia generation, provided that bacterial enzymes are present. 7. Bacterial generation of organic solute in faeces which have left the body is sufficiently rapid to cast serious doubts on the validity of faecal centrifugation, or other time-consuming techniques involving lengthy handling of faeces, as methods of obtaining extracellular faecal fluid for measurements of organic constituents or ammonia.
Clin Sci Mol Med 1976 Sep
PMID:Generation of ammonia from non-urea sources in a faecal incubation system. 0 21


J Mol Biol 1976 Sep 05
PMID:Mutational amino acid replacements in Neurospora crassa NADP-specific glutamate dehydrogenase. 0 17


J Mol Biol 1976 Sep 05
PMID:Helical transformations of Salmonella flagella in vitro. 0 18


J Mol Biol 1976 Sep 15
PMID:Three-state denaturation of alpha-lactalbumin by guanidine hydrochloride. 1 Apr 45


J Mol Biol 1976 Sep 25
PMID:Structure of the single-stranded polyribonucleotide polycytidylic acid. 1 Apr 46


Mol Pharmacol 1976 Sep
PMID:Hydroxybenzylpindolol and hydroxybenzylpropranolol: partial beta adrenergic agonists of adenylate cyclase in the rat adipocyte. 1 7


Mol Pharmacol 1976 Sep
PMID:2-Fluoro-L-histidine, an inhibitor of enzyme induction. 1 8


Mol Pharmacol 1977 Sep
PMID:Electron densities in neuroleptics by X-ray photoelectron spectroscopy, 13C nuclear magnetic resonance, and quantum calculations on model compounds. 1 94


Mol Pharmacol 1977 Sep
PMID:Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation. 1 95

Treatment of rat thymocytes with cortisol induced an inhibition of [3H]uridine incorporation after 30-90 min, an accumulation of pycnotic cells after 90 min, and a decrease in cell viability after several hours. No cortisol-resistant cells could be distinguished, and dose-response curves for a number of glucocorticoids showed a correlation to the saturation of the glucocorticoid receptors. The pycnotic effect of cortisol increased between pH 5.2--7.0 in parallel with a stimulation of the spontaneous development of pycnotic cells. The cortisol-induced accumulation of pycnotic cells and inhibition of [3H]uridine incorporation varied independently as a function of the cell density, and in a glucose-salt medium only the pycnotic effect of cortisol became inhibited. The inhibition of [3H] uridine incorporation is therefore not an integral part of the pycnotic change of the cells. The glucocorticoid sensitivity was found to increase with the age of the animals, before the onset of thymus involution.
Mol Cell Endocrinol 1977 Sep
PMID:Dissociation between cortisol-induced pycnosis and inhibition of [3H]uridine incorporation in rat thymocytes. 2 26


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