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Query: UNIPROT:P06889 (Mol)
 630,302 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several new transition metal complexes derived from 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine (HL) have been prepared and characterized by elemental analyses, 1H-NMR, magnetic susceptibility, IR, UV, EPR and thermal analyses. Stereochemistries are proposed for the complexes on the basis of the spectral and magnetic studies. The i.r. data indicate that the carbonyl oxygen of the carboxamide constituents chelating backbone in most complexes. The visible and EPR spectral studies indicated that the Cu(II) complexes have a tetragonal geometry. From the EPR spectrum of the Cu(II) complexes, various parameters were calculated.
Spectrochim Acta A Mol Biomol Spectrosc 2001 Jan
PMID:Spectral studies on metal-ligand bonding in complexes of 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine. 1120 66

Single crystal EPR of Cu(II)-doped low symmetry pentagonal bipyramidal Werner-type clathrate inclusion complexes of Cd(stpy)3(NO3)2 x 1/2stpy(1) and Zn(stpy)3(NO3)2 x 1/2stpy(2) (stpy = trans-4-styrylpyridine) is reported. The spin Hamiltonian parameters are found to be orthorhombic with g33 = 2.298, g22 = 2.108, g11 = 2.066, A33 = 107.3, A22 = 54.4 and A11 = 23.1 x 10(-4) cm(-1) for 1 and g33 = 2.292, g22 = 2.111, g11 = 2.067, A33 = 107.5, A22 = 54.7 and A11 = 22.9 x 10(-4) cm(-1) for 2. Angular variation studies for both 1 and 2 suggest that the Cu(II) ions are substitutionally incorporated in the host lattices. The magnitude of Cu(II) hyperfine coupling constant (A33) in both 1 and 2 are found to be low, in comparison to those of the pure Cu(II) complex, indicative of low symmetry for the substitutional sites in accordance with the crystal data. Such large reductions in Cu(II) hyperfine coupling are explicable in terms of a mixed d(x2 - y2)/dz2 ground state and delocalization of unpaired spin density onto the ligands.
Spectrochim Acta A Mol Biomol Spectrosc 2001 Mar 01
PMID:EPR of Cu(II)-doped seven-coordinate inclusion compounds, M(stpy)3(NO3)2 x 1/2stpy (M = Cd(II) and Zn(II), stpy = trans-4-styrylpyridine): low symmetry effects in admixture of ground states. 1130 May 55

EPR, Optical and IR spectral studies on a naturally occurring mineral melanterite are carried out at room temperature. EPR studies indicate the presence of Cu(II) ion in tetragonally distorted octahedral site and hyperfine lines could not be resolved due to higher concentration of the paramagnetic impurity in the mineral. Optical absorption spectrum is a characteristic of Fe(II) and Cu(II) ions. Crystal field parameters are evaluated. IR spectrum confirms the presence of water and sulphate ions.
Spectrochim Acta A Mol Biomol Spectrosc 2001 May
PMID:Spectral investigations on melanterite mineral from France. 1141 70

New bis[N-(2,6-di-t-butyl-1-hydroxyphenyl)salicylideneminato]copper(II) complexes bearing HO and CH3O substituents on the salicyaldehyde moiety were prepared, and their spectroscopic properties, as well as redox reactivity towards PbO2 and PPh3, examined by ESR and UV spectroscopy. In the process of synthesis of HO complexes unlike CH3O the oxidative C-C coupling of coordinated salicylaldimine ligands does not takes place. The powder ESR spectra of CH3O substituted complexes unlike of HO analogues are typical of a triplet state Cu(II) dimers with a half-field forbidden (deltaM = +/- 2) transition and the allowed transitions (AM = +/- 1) dimeric form of the complexes at 300 and 113 K. The one-electron oxidation of 3-CH3O and all of the OH complexes with PbO2 to give indophenoxyl type secondary radicals which are significantly different from those observed for analogues Cl, Br and NO2 substituted chelates. The presented complexes unlike their electron-withdrawing analogues are readily reduced by PPh3 via intramolecular electron transfer from ligand to copper(II) to give various radical intermediates as well as Cu(I) radical ligand compounds. The analysis of ESR spectra all of the complexes and radical intermediates are presented.
Spectrochim Acta A Mol Biomol Spectrosc 2001 Jul
PMID:Synthesis, spectroscopic characterization and ESR studies on electron transfer reactions of bis[N-(2,6-di-tert-butyl-1-hydroxyphenyl)salicylaldiminato]-copper(II) complexes with PbO2 and PPh3. 1147 18

A series of novel complexes with 5-sulphadiazineazo-3-phenyl-2-thioxo-4-thiazolidinone (H2L1) and 5-sulphamethazineazo-3-phenyl-2-thioxo-4-thiazolidinone (H2L2) and various anions were prepared. Their structures and properties were characterized by elemental analyses, IR, UV-vis, EPR spectroscopy and magnetic measurements. The visible and EPR spectral studies indicated that the Cu(II) complexes have distorted octahedral. From the electron paramagnetic resonance and spectral data, the orbital reduction factors k(parallel) and k(perpendicular) were calculated. In all cases k(perpendicular) > k(parallel) indicates a 2B1g ground state. The crystal field parameters for Co(II) and Ni(II) complexes were calculated. The electronic absorption and a g(parallel)/A(parallel) values are indicative for the beginning of tetragonal distortion. The complexes, however, have lower symmetries and the amount of distortion in terms of DT/Dp, applying NSH 'Hamiltonian Theory' has been evaluated which indicate that the complexes are moderately distorted.
Spectrochim Acta A Mol Biomol Spectrosc 2001 Aug
PMID:Spectral studies on metal-ligand bonding of novel rhodanine azodye sulphadrugs. 1150 26

This paper reports a novel reaction of metallotetraphenylporphyrins on hydroxyl-modified silver colloid and Ag2O colloid. Surface-enhanced Raman spectra of Ag(II) and Cu(II) complexes of tetraphenylporphyrin (TPP) adsorbed on the hydroxyl-modified Ag colloid and Ag2O colloid have been studied. The time-dependent SERS spectra of MTPP (M = Ag, Cu) on hydroxyl-modified Ag colloid were recorded and dramatic change on SERS spectra was observed. The final spectra were found to be strikingly different from the corresponding normal Raman spectra (NRS), with the appearance of new Raman bands at 1614. 1417, 947, 674 and 292 cm(-1). The UV-visible absorption spectrum of MTPP on hydroxyl-modified Ag colloid exhibits a broad shoulder near 460 nm. Similar spectral phenomena were also observed for AgTPP and CuTPP adsorbed on Ag2O colloid. The observed spectral alterations were ascribed to new species formation due to the irreducible oxidation of MTPP on the colloids.
Spectrochim Acta A Mol Biomol Spectrosc 2001 Nov
PMID:Reaction of metallotetraphenylporphyrins on hydroxyl-modified silver colloid and Ag2O colloid by surface-enhanced Raman scattering. 1176 87

Single crystal electron paramagnetic resonance (EPR) studies on Cu(II) doped zinc potassium phosphate hexahydrate (ZPPH) were carried out at room temperature. The angular variation spectra in the three orthogonal planes indicate that the paramagnetic impurity has entered the lattice substitutionally in place of Zn(II) and the spin Hamiltonian parameters calculated from these spectra are g(xx) = 2.188, g(yy) = 2.032, g(zz) = 2.373, Axx = 50 G, Ayy = 65.0 G and Azz = 80 G. The g and A tensors were coincident and these values matched fairly well with the values obtained from powder spectrum. The bonding parameters have also been calculated.
Spectrochim Acta A Mol Biomol Spectrosc 2001 Dec
PMID:Single crystal EPR and optical studies of paramagnetic ions doped zinc potassium phosphate hexahydrate--part I: Cu(II)--a case of orthorhombic symmetry. 1178 79

The reaction products of metal(II) salts with 5-sulphamethoxazoleazo-3-phenyl-2-thioxo-4-thiazolidinone (H2L) have been characterized by elemental analyses, magnetic susceptibility, electronic, infrared and electron paramagnetic resonance spectral measurements. The spectral data suggest a square pyramidal structure for Cu(II) and Co(II) complexes and an octahedral for Ni(II) complexes. Various EPR parameters have been calculated. From the electron paramagnetic resonance and spectral data, the orbital reduction factors were calculated. In all case kperpendicular > kparallel which indicates a 2B1g ground state. These five coordinated complex of Cu(II) react further with pyridine forming six coordinate base adduct. The different modes of chelation of the ligand and stereochemistry around the metal ion are discussed.
Spectrochim Acta A Mol Biomol Spectrosc 2002 Jan 15
PMID:Coordination modes of novel rhodanine azodye complexes. 1180 38

Pyridoxal isonicotinoyl hydrazone (PIH) is an iron chelator with antioxidant activity, low toxicity and is useful in the experimental treatment of iron-overload diseases. Previous studies on x-ray diffraction have revealed that PIH also forms a complex with Cu(II). Since the main drug of choice for the treatment of Wilson's disease, d-penicillamine, causes a series of side effects, there is an urgent need for the development of alternative copper chelating agents for clinical use. These chelators must also have antioxidant activity because oxidative stress is associated with brain and liver copper-overload. In this work we tested the ability of PIH to prevent in vitro free radical formation mediated by Cu(II), ascorbate and dissolved O2. Degradation of 2-deoxyribose mediated by 10 microM Cu(II) and 3 mM ascorbate was fully inhibited by 10 microM PIH (I50 = 6 microM) or 20 microM d-penicillamine (I50 = 10 microM). The antioxidant efficiency of PIH remained unchanged with increasing concentrations (from 1 to 15 mM) of the hydroxyl radical detector molecule, 2-deoxyribose, indicating that PIH does not act as a hydroxyl scavenger. On the other hand, the efficiency of PIH (against copper-mediated 2-deoxyribose degradation and ascorbate oxidation) was inversely proportional to the Cu(II) concentration, suggesting a competition between PIH and ascorbate for complexation with Cu(lI). An almost full inhibitory effect by PIH was observed when the ratio PIH:copper was 1:1. A similar result was obtained with the measurement of copper plus ascorbate-mediated O2 uptake. Moreover, spectral studies of the copper and PIH interaction showed a peak at 455 nm and also indicated the formation of a stable Cu(II) complex with PIH with a 1:1 ratio. These data demonstrated that PIH prevents hydroxyl radical formation and oxidative damage to 2-deoxyribose by forming a complex with Cu(II) that is not reactive with ascorbate (first step of the reactions leading to hydroxyl radical formation from Cu(II), ascorbate and O2) and does not participate in Haber-Weiss reactions.
Mol Cell Biochem 2001 Dec
PMID:Pyridoxal isonicotinoyl hydrazone (PIH) prevents copper-mediated in vitro free radical formation. 1185 43

Low temperature electron paramagnetic resonance (EPR) spectroscopy with frequencies between 95 and 345 GHz and magnetic fields up to 12 T have been used to study radicals and metal sites in proteins and small inorganic model complexes. We have studied radicals, Fe, Cu and Mn containing proteins. For S = 1/2 systems, the high frequency method can resolve the g-value anisotropy. It was used in mouse ribonucleotide reductase (RNR) to show the presence of a hydrogen bond to the tyrosyl radical oxygen. At 285 GHz the type 2 Cu(II) signal in the complex enzyme laccase is clearly resolved from the Hg(II) containing laccase peroxide adduct. For simple metal sites, the systems over S = 1/2 can be described by the spin Hamiltonian: H(S) = BgS + D[Sz2 - S(S + 1)/3 + E/D (Sx2 - Sy2)]. From the high frequency EPR the D-value can be determined directly by, (I) shifts of g(eff) for half-integer spin systems with large D-values as observed at 345 GHz on an Fe(II)-NO-EDTA complex, which is best described as S = 3/2 system with D = 11.5 cm(-1), E = 0.1 cm(-1) and gx = gy = gz = 2.0; (II) measuring the outermost signal, for systems with small D values, distant of (2S - 1) x absolute value(D) from the center of the spectrum as observed in S= 5/2 Fe(III)-EDTA. In Mn(II) substituted mouse RNR R2 protein the weakly interacting Mn(II) at X-band could be observed as decoupled Mn(II) at 285 GHz.
Spectrochim Acta A Mol Biomol Spectrosc 2002 Apr
PMID:The use of high field/frequency EPR in studies of radical and metal sites in proteins and small inorganic models. 1199 59


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