Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P06126 (CD1a)
 2,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In conclusion we have shown that motile cells with a dendritic morphology can be isolated from dermis of normal and diseased human skin. DDC bear high amounts of MHC class II molecules on their surface, and are very potent antigen presenting cells. Subpopulations of these cells acquire certain ultrastructural features of Langerhans cells in-vitro such as Birbeck granule formation and CD1a expression. These newly defined members of the dendritic cell family of APCs may be precursors of epidermal Langerhans cells and may play a role in skin immune responses. Furthermore in inflammatory dermatoses such as psoriasis, a role in the autostimulation and cytokine production of T cells could be demonstrated. Given their number, distribution, and in-vitro functional capacity, it is appropriate at this time to conclude that DDCs are indeed important members of the skin immune system.
 ...
PMID:Dermal dendritic cells are important members of the skin immune system. 852 32

In cancer patients pervasive systemic suppression of Dendritic Cell (DC) differentiation and maturation can hinder vaccination efficacy. In this study we have extensively characterized migratory DC subsets from human skin and studied how their migration and T cell-stimulatory abilities were affected by conditioning of the dermal microenvironment through cancer-related suppressive cytokines. To assess effects in the context of a complex tissue structure, we made use of a near-physiological skin explant model. By 4-color flow cytometry, we identified migrated Langerhans Cells (LC) and five dermis-derived DC populations in differential states of maturation. From a panel of known tumor-associated suppressive cytokines, IL-10 showed a unique ability to induce predominant migration of an immature CD14(+)CD141(+)DC-SIGN(+) DC subset with low levels of co-stimulatory molecules, up-regulated expression of the co-inhibitory molecule PD-L1 and the M2-associated macrophage marker CD163. A similarly immature subset composition was observed for DC migrating from explants taken from skin overlying breast tumors. Whereas predominant migration of mature CD1a(+) subsets was associated with release of IL-12p70, efficient Th cell expansion with a Th1 profile, and expansion of functional MART-1-specific CD8(+) T cells, migration of immature CD14(+) DDC was accompanied by increased release of IL-10, poor expansion of CD4(+) and CD8(+) T cells, and skewing of Th responses to favor coordinated FoxP3 and IL-10 expression and regulatory T cell differentiation and outgrowth. Thus, high levels of IL-10 impact the composition of skin-emigrated DC subsets and appear to favor migration of M2-like immature DC with functional qualities conducive to T cell tolerance.
...
PMID:IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation. 2387 23