Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P06126 (
CD1a
)
2,221
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Zoledronic acid
(
ZOL
), an effective nitrogen-containing bisphosphonate against excessive bone loss, has been shown affecting the function of cells of both innate and acquired immunity. In this study, we tested the effect of
ZOL
on differentiation and maturation of human myeloid dendritic cells (DC). When
ZOL
(1.1 to 10 microM) was added to the culture of starting monocytes, but not to immature DC, the recovery rate of DC was markedly reduced in a concentration-dependent manner. The mature DC differentiated in the presence of
ZOL
had fewer and shorter cell projections.
ZOL
treatment affected DC differentiation and maturation in terms of lower expression of
CD1a
, CD11c, CD83, CD86, DC-SIGN, HLA-DR, and, in contrast, higher expression of CD80. IL-10 production by DC was inhibited by
ZOL
treatment whereas IL-12p70 secretion remained unchanged. Interestingly,
ZOL
augmented the allostimulatory activity of DC on naive CD4(++)CD45(+)RA(++) T cells in terms of their proliferation and interferon-gamma production. Addition of geranylgeraniol abrogated the effect of
ZOL
on DC differentiation and prenylation of Rap1A. It suggests that
ZOL
redirects DC differentiation toward a state of atypical maturation with allostimulatory function and this effect may go through prevention of Rap1A prenylation.
...
PMID:Zoledronic acid, an aminobisphosphonate, modulates differentiation and maturation of human dendritic cells. 1955 8
