Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P06126 (CD1a)
 2,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The CD1 gene family is composed of five distinct molecules: CD1a, b, c, d and e. CD1a, b and c are primarily expressed thymically with limited extrathymic expression. Preliminary studies have shown that CD1d is primarily expressed extrathymically in gastrointestinal epithelial cells, renal tubular epithelial cells and B cells. This report characterizes the expression of CD1d in a variety of human tissues by immunohistochemistry using two anti-human CD1d monoclonal antibodies (mAb). CD1d was found in a wide range of tissues including the intestine, liver, pancreas, skin, kidney, uterus, conjunctiva, epididymis, thymus and tonsil. Within those tissues CD1d was mainly present in epithelial cells, vascular smooth muscle cells and parenchymal cells. Therefore, the tissue distribution of CD1d is distinct from CD1a-c and classical major histocompatibility complex (MHC) proteins implicating a unique role for CD1d in the immune system.
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PMID:Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule, CD1d. 750 19

Infection and inflammation of the genital tract are thought to be a primary aetiological factor of male infertility. Chronic epididymitis appears to be more important than prostatitis or seminal vesiculitis due to the direct interaction between sperm cells and epididymal epithelium. Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells that play a crucial role in the regulation of the immune response and immunological tolerance. The aim of this study was to investigate the expression and characteristic of different DC subsets in chronic inflammation of human epididymis and controls. Our study demonstrated that normal human epididymis contained only immature CD1a(+) DCs, CD11c(+) myeloid DCs (mDCs) and CD209(+) DCs whereas CD123(+) plasmacytoid DCs and CD83(+) mature DCs were virtually absent. The number of both CD11c(+) IL-23(+) mDCs and CD123(+) pDCs were significantly elevated in inflamed epididymis; meanwhile the mDC populations of CD1a(+), CD209(+) immature DCs and CD83(+) mature DCs also increased in inflamed group. Moreover, Th17 (CD4(+) IL-17(+)) cells were predominantly distributed under chronic inflammation of human epididymis. Taken together these results suggest that epididymal DCs might play a pivotal role in the development of chronic epididymitis and induce an increased recruitment of Th17 cells under inflammatory conditions.
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PMID:Characterisation of dendritic cell subsets in chronically inflamed human epididymis. 2625 53