Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P06126 (CD1a)
 2,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cortical thymocytes expressed at least three distinct cell-surface differentiation antigens. CD1a (Mr 49,000), CD1b (Mr 45,000) and CD1c (Mr 43,000) which are non-covalently attached to beta 2-microglobulin. In the present study, we confirm the presence of two out of the three CD1 molecules on epidermal Langerhans cells by biochemical analysis. Furthermore some CD1a monoclonal antibodies immunoprecipitated an additional molecule with an apparent relative mass of 27,000 from Langerhans cell-enriched epidermal cell lysates and not from fresh iodinated thymocyte lysates. From trypsin-treated thymocyte lysates, this low molecular weight protein was considered as a cleavage product of Mr 49,000 molecule (CD1a molecule) by this enzyme which is used to obtain epidermal cell suspensions. This Mr 27,000 was found to content one N-linked oligosaccharide residue by endoglycosidase F treatment. On CD1-expressing cells (thymocytes and Langerhans cells) it would be tempting to take advantage of the sensitivity of CD1a molecule to trypsin in order to precise the structure/function relationship of CD1a antigen.
Thymus 1990 Jun
PMID:The effect of trypsin on CD1a molecule of human thymocytes. 169 34

Langerhans cells and thymocytes were comparatively studied for their monoclonal antibody-induced endocytic activity. The two cell types were CD1a or Class I-HLA immunolabeled, incubated under similar conditions and the effects induced on membrane mobility were analyzed by a fluorescence method for the thymocytes and at the ultrastructural level for both cell types. We provide evidence that thymocytes are able to cap and internalize by receptor-mediated endocytosis CD1a antigen and Class I-HLA, whereas Langerhans cells present only a process of internalization by receptor-mediated endocytosis for both membrane antigens.
Thymus
PMID:Comparative study of in vitro CD1a and HLA-class I antigens endocytosis by human thymocytes and Langerhans cells. 247 27