Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P06126 (CD1a)
 2,221 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Limbal conjunctival biopsies from 8 patients with atopic dermatitis and from 5 age-matched healthy individuals undergoing cataract or retinal detachment surgery were analyzed by light microscopy and immunological techniques. They were immuno-double labelled with anti-CD1a and anti-IgE or anti-CD23 (IgE receptor). In the specimens from atopic dermatitis 24 approximately 75% of positive anti-CD1a staining cells were double-stained by anti-IgE. Weak positive immuno-double stained cells with anti-CD23 were also observed, but less than with anti-IgE. The ratio of positive anti-IgE double-stained cells to positive anti-CD1a stained cells seemed to be parallel to serum IgE level, but not significant. The presence of IgE and CD23 (IgE receptor) on conjunctival Langerhans cells seems to have a positive effect on IgE-dependent antigen presentation.
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PMID:[The presence of IgE on limbal Langerhans cells in patients with atopicdermatitis]. 865 Oct 58