Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
c-Jun
11453
p38
2323
AP-1
2252
JNK
2153
Mol
1425
MAPK
1019
extracellular signal-regulated kinase
984
mitogen-activated protein
969
ERK1
858
Sep
789
caspase-3
749
ERK
737
cytokine
687
JNK1
671
tumor necrosis factor
593
p53
550
lipopolysaccharide
510
Bcl-2
459
p65
454
TNF
429
c-fos
413
p38 mitogen-activated protein kinase
405
IL-6
371
MEK
363
insulin
354
JNK2
336
MAP kinase
301
ATF
294
MKK4
272
cyclooxygenase-2
259
cytochrome c
243
inducible nitric oxide synthase
238
MEK1
231
extracellular signal-regulated kinase 1
220
matrix metalloproteinase
217
collagen
208
cyclin D1
208
c-Myc
206
p21
204
AKT
204
more...
Disease
cancer
1643
tumor
1164
tumorigenesis
325
breast cancer
304
ischemia
285
carcinogenesis
282
hepatocellular carcinoma
233
diabetes
221
carcinoma
217
Alzheimer's disease
200
leukemia
192
tumor growth
173
obesity
157
prostate cancer
144
tumor progression
140
melanoma
139
atherosclerosis
138
MCF
128
GSH
125
Parkinson's disease
123
colon cancer
116
lung cancer
112
neuroblastoma
103
glioma
96
stroke
95
cerebral ischemia
88
adenocarcinoma
85
hypertension
83
squamous cell carcinoma
81
metastases
77
rheumatoid arthritis
76
colorectal cancer
75
ovarian cancer
64
type 2 diabetes
63
lymphoma
62
asthma
60
gastric cancer
58
retinoblastoma
58
arthritis
57
virus infection
57
more...
Symptom
seizures
63
pain
46
starvation
38
functional recovery
23
skin damage
18
collapse
14
diarrhea
12
hyperoxia
11
hypothermia
10
anesthesia
8
exhaustion
8
cough
6
fatigue
5
memory loss
5
ataxia
5
weakness
5
acute stress
5
erythema
4
analgesia
4
respiratory distress
4
cachexia
3
Neuropathic pain
3
splenomegaly
3
thinning
3
tremor
3
hepatomegaly
3
vomiting
2
flushing
2
overweight
2
sore throat
2
anorexia
2
lethargy
2
headache
2
hypercapnia
2
masculinization
1
Ear swelling
1
acute pain
1
neurological disability
1
discomfort
1
twitching
1
more...
Drug
MAP
159
ROS
104
Gel
100
IL-2
82
IFN-gamma
71
Dermatol
57
lysine
54
DNase I
36
Angiotensin II
33
p75
31
CSF
30
vitamin E
25
ascorbate
23
Heme
23
Cardiovasc
21
Arsenic trioxide
20
IFN-beta
19
Glutathione
19
Retinoic acid
16
ETS
15
ICI
14
Ethanol
13
ADR
12
TAT
11
caffeine
11
EE2
11
IL-11
11
Gelatin
10
Taxol
10
Indomethacin
9
ETA
9
Bortezomib
9
Lovastatin
8
Asn
8
Nephron
8
Monit
8
Estrogens
7
uPA
7
TAK
7
Forskolin
7
more...
Enzyme
mitogen-activated protein kinase
5022
protein kinase
1212
ERK
955
MEK
840
caspase-3
596
protein kinase C
530
luciferase
430
focal adhesion kinase
222
collagenase
200
MEKK1
197
phosphatidylinositol 3-kinase
192
PARP
166
proteasome
158
catalase
153
MAP
153
superoxide dismutase
136
glutathione S-transferase
133
caspase-9
131
IKK
113
caspase-8
111
calcineurin
93
NADPH oxidase
90
NO synthase
90
NADPH oxidase
81
phosphoinositide 3-kinase
78
AMP-activated protein kinase
70
GSK
62
peroxidase
56
thrombin
54
phospholipase C
54
MMP-3
51
urokinase-type plasminogen activator
51
chloramphenicol acetyltransferase
50
lactate dehydrogenase
50
glutathione peroxidase
47
alanine aminotransferase
45
cdc2
44
alkaline phosphatase
43
AMPK
42
RNA polymerase
41
more...
Compound
DNA
2017
NH2
1214
oxygen
894
Dec
827
acetate
467
TNF
429
tyrosine
382
nitric oxide
329
serine
322
calcium
321
glucose
298
MEK
294
ATF
294
cAMP
265
threonine
242
cysteine
201
hydrogen
162
AMP
153
MAP
153
sodium
152
water
152
Clin
138
ATP
137
GSH
133
GSH
133
N-acetylcysteine
130
MTT
125
MDA
112
H2O2
104
THP
104
THP
103
retinoic acid
102
TPA
99
TPA
99
glutamate
91
leucine
89
alanine
84
ethanol
83
PMA
82
PMA
81
more...