Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P05412 (c-Jun)
 11,453 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
c-Jun 11453
p38 2323
AP-1 2252
JNK 2153
Mol 1425
MAPK 1019
extracellular signal-regulated kinase 984
mitogen-activated protein 969
ERK1 858
Sep 789
caspase-3 749
ERK 737
cytokine 687
JNK1 671
tumor necrosis factor 593
p53 550
lipopolysaccharide 510
Bcl-2 459
p65 454
TNF 429
c-fos 413
p38 mitogen-activated protein kinase 405
IL-6 371
MEK 363
insulin 354
JNK2 336
MAP kinase 301
ATF 294
MKK4 272
cyclooxygenase-2 259
cytochrome c 243
inducible nitric oxide synthase 238
MEK1 231
extracellular signal-regulated kinase 1 220
matrix metalloproteinase 217
cyclin D1 208
collagen 208
c-Myc 206
AKT 204
p21 204
endoplasmic reticulum 202
CREB 201
TNF-alpha 194
phosphatase 193
phosphatidylinositol 3-kinase 192
leucine zipper 191
tyrosine kinase 189
ERK2 185
AP1 172
IL-8 171
p38 MAP kinase 169
Fas 166
interleukin-6 165
caspase-9 163
threonine 160
p50 157
proteasome 155
LPS 155
PI3K 155
caspase-8 152
MAP 152
AMP 151
epidermal growth factor 149
PARP 149
Sp1 148
proto-oncogene 148
TLR4 145
ATF2 144
MKK7 142
ATP 137
ubiquitin 135
MEKK1 132
MMP-9 132
Rho 132
p42 128
GSH 125
PKC 125
COX-2 124
vascular endothelial growth factor 124
JNK3 123
epidermal growth factor receptor 123
protein kinase B 119
chemokine 116
superoxide dismutase 116
heme oxygenase-1 115
mTOR 113
nitric oxide synthase 112
catalase 110
axonal 107
STAT3 106
nerve growth factor 105
tumor necrosis factor alpha 105
interferon 105
ROS 104
p44 104
histone 103
THP 103
CA1 103
IL-1 101
p300 101
transactivator 99
IkappaBalpha 99
TPA 99
estrogen receptor 98
angiotensin II 97
catenin 96
Raf-1 92
MMP-1 92
IL-10 90
poly(ADP-ribose) polymerase 90
ras 88
collagenase 87
Tumor necrosis factor 85
MEKK 85
Nrf2 85
EBP 84
cyclooxygenase 82
nuclear protein 82
erythroid 82
fibronectin 82
IL-2 82
SOD 81
IFN 79
phosphoinositide 3-kinase 78
glutathione S-transferase 78
interacting protein 78
Ang II 77
JUN 75
MMP-2 75
EGF 74
glucocorticoid receptor 73
transcriptional factor 72
p38MAPK 72
IFN-gamma 71
IRS-1 71
apoptosis signal-regulating kinase 1 70
TRE 70
TGF-beta 70
DNA-binding domain 69
GST 67
focal adhesion kinase 67
c-myc 66
CD4 65
GTP 65
p27 65
platelet-derived growth factor 63
IKK 62
TLR2 62
P38 62
fused 62
E-cadherin 62
RhoA 61
beta-catenin 61
MKK3 60
Smad3 60
cyclin 60
dimeric 59
histone deacetylase 59
phosphorylating 59
Fas ligand 59
more...
Disease
cancer 1643
tumor 1164
tumorigenesis 325
breast cancer 304
ischemia 285
carcinogenesis 282
hepatocellular carcinoma 233
diabetes 221
carcinoma 217
Alzheimer's disease 200
leukemia 192
tumor growth 173
obesity 157
prostate cancer 144
tumor progression 140
melanoma 139
atherosclerosis 138
MCF 128
GSH 125
Parkinson's disease 123
colon cancer 116
lung cancer 112
neuroblastoma 103
glioma 96
stroke 95
cerebral ischemia 88
adenocarcinoma 85
hypertension 83
squamous cell carcinoma 81
metastases 77
rheumatoid arthritis 76
colorectal cancer 75
ovarian cancer 64
type 2 diabetes 63
lymphoma 62
asthma 60
gastric cancer 58
retinoblastoma 58
virus infection 57
arthritis 57
B-cell lymphoma 55
multiple myeloma 54
osteosarcoma 54
heart failure 53
Blocking 52
glioblastoma 52
non-small cell lung cancer 52
neoplastic transformation 51
pancreatic cancer 51
pertussis 50
cervical cancer 49
sepsis 48
skin cancer 48
Epstein 47
hyperglycemia 47
sepsis 46
osteoarthritis 44
ATM 44
acute myeloid leukemia 44
infectious diseases 42
TAM 41
fatty liver 41
acute promyelocytic leukemia 40
HIV 40
hepatitis B 38
plaque 38
cardiovascular disease 37
pheochromocytoma 36
liver cancer 36
psoriasis 36
colitis 35
myocardial ischemia 34
depression 34
CEP 33
lung carcinoma 33
liver cancer 32
myocardial infarction 32
Infection 32
metabolic syndrome 31
cognitive impairment 31
pulmonary fibrosis 31
osteoporosis 30
immunodeficiency 29
epithelial ovarian cancer 29
inflammatory bowel disease 28
chronic obstructive pulmonary disease 27
liver fibrosis 27
cirrhosis 27
diabetic nephropathy 27
bladder cancer 26
AGS 26
amyotrophic lateral sclerosis 24
JIP 24
epilepsy 24
glucose intolerance 23
fibrosarcoma 23
Huntington's disease 22
insulinoma 22
liver disease 22
renal disease 22
MIP 22
dermatitis 22
Leukemia 21
herpes simplex 21
multiple sclerosis 21
sarcoma 20
Mycobacterium 20
acute lymphoblastic leukemia 20
dementia 20
mammary tumor 20
Adenovirus 20
cold 20
chronic myeloid leukemia 19
tuberculosis 19
systemic lupus erythematosus 19
primary tumor 19
tumor angiogenesis 19
glioblastoma multiforme 19
acute pancreatitis 18
esophageal cancer 18
cytomegalovirus 18
SDS 18
ulcerative colitis 18
Hepatocellular carcinoma 18
embryonal carcinoma 17
hepatitis 17
renal cell carcinoma 17
skin tumor 17
Osteosarcoma 16
Osteosarcoma 16
aggressiveness 16
esophageal cancer 16
erythroleukemia 16
atopic dermatitis 16
myeloid leukemia 15
chronic lymphocytic leukemia 15
type 1 diabetes 15
bacterial infection 15
Melanoma 14
adenoma 14
periodontitis 14
muscular atrophy 14
influenza 14
astrocytoma 14
Kaposi's sarcoma 14
status epilepticus 14
metastatic breast cancer 14
brain tumor 14
chondrosarcoma 14
metastatic melanoma 14
skin disease 14
Hodgkin's disease 13
cornea 13
periodontal disease 13
APC 13
small cell lung cancer 13
pruritus 13
dysplasia 13
glomerulosclerosis 13
hepatitis C 13
more...
Symptom
seizures 63
pain 46
starvation 38
functional recovery 23
skin damage 18
collapse 14
diarrhea 12
hyperoxia 11
hypothermia 10
exhaustion 8
anesthesia 8
cough 6
weakness 5
ataxia 5
fatigue 5
memory loss 5
acute stress 5
analgesia 4
respiratory distress 4
erythema 4
splenomegaly 3
thinning 3
tremor 3
hepatomegaly 3
cachexia 3
Neuropathic pain 3
flushing 2
vomiting 2
lethargy 2
sore throat 2
anorexia 2
overweight 2
headache 2
hypercapnia 2
despair 1
bladder pain 1
Ear swelling 1
bradykinesia 1
acute pain 1
neurological disability 1
discomfort 1
twitching 1
spasticity 1
tinnitus 1
nasal congestion 1
chorea 1
paraparesis 1
Somatic pain 1
chronic constipation 1
discomfort 1
shortness of breath 1
back pain 1
constipation 1
chronic cough 1
acidity 1
HSA 1
incoordination 1
distraction 1
dry eye 1
DNA marker 1
masculinization 1
Bladder distention 1
dyspnea 1
dystonia 1
low back pain 1
intention tremor 1
abdominal pain 1
spasm 1
paresis 1
enuresis 1
Drug
MAP 159
ROS 104
Gel 100
IL-2 82
IFN-gamma 71
Dermatol 57
lysine 54
DNase I 36
Angiotensin II 33
p75 31
CSF 30
vitamin E 25
Heme 23
ascorbate 23
Cardiovasc 21
Arsenic trioxide 20
IFN-beta 19
Glutathione 19
Retinoic acid 16
ETS 15
ICI 14
Ethanol 13
ADR 12
IL-11 11
EE2 11
TAT 11
caffeine 11
Gelatin 10
Taxol 10
Bortezomib 9
Indomethacin 9
ETA 9
Asn 8
Lovastatin 8
Nephron 8
Monit 8
Estrogens 7
uPA 7
TAK 7
G-CSF 7
Forskolin 7
Sorafenib 6
CTX 6
Silica 6
Simvastatin 6
Parkin 6
Parkin 6
DHT 5
Kainic acid 5
DHT 5
Histamine 5
Emodin 5
Activin 5
Adriamycin 5
CTX 5
CTX 5
Emodin 5
GEO 5
Biopolymers 5
CED 5
Portal 4
Docetaxel 4
CCL 4
Vitamin A 4
Ginseng 4
Glucagon 4
PCP 4
Glycyrrhiza 4
Rosiglitazone 4
ZnO 4
Imatinib 4
Nitric Oxide 4
Growth hormone 4
IL-1ra 4
Etoposide 4
Epigallocatechin 4
Growth hormone 4
Photofrin 3
Doxycycline 3
Leaf 3
AMC 3
Lenalidomide 3
Dihydrotestosterone 3
MRC 3
Alanine 3
Kenyan 3
Myricetin 3
ADM 3
Vitamin E 3
CPT-11 3
NBT 3
Gefitinib 3
Asthma 3
EPA 3
Gleevec 3
DEX 3
Trifluoroethanol 2
Tacrolimus 2
CDP 2
Ouabain 2
TTC 2
TiO2 2
NOV 2
Dial 2
BH4 2
Nephron 2
Bifidobacterium 2
Vitamin K 2
-deoxyadenosine 2
Cilostazol 2
Sodium nitroprusside 2
PDL 2
Hyperforin 2
Dexrazoxane 2
VCR 2
Rolipram 2
Pravastatin 2
Finasteride 2
Bevacizumab 2
Imiquimod 2
Rutin 2
PFT 2
Cetuximab 2
Prednisolone 2
Phosphatidylserine 2
CMX 2
GRF 2
ALA 2
TAC 2
PDGF B-chain 2
Amiloride 2
FAD 2
Doyle 2
NADH 2
ABC 2
Areca 2
Erlotinib 2
2-Methoxyestradiol 2
SNL 1
ENT 1
Escitalopram 1
Fructose 1
Cetrorelix 1
Plavix 1
Olmesartan 1
Anakinra 1
Taxotere 1
Troglitazone 1
MTC 1
Verteporfin 1
CaCl2 1
Levosimendan 1
Sodium benzoate 1
Bupivacaine 1
CaCl2 1
Mutagen 1
Ranitidine 1
Tannic acid 1
Sesamol 1
balanced salt solution 1
more...
Enzyme
mitogen-activated protein kinase 5022
protein kinase 1212
ERK 955
MEK 840
caspase-3 596
protein kinase C 530
luciferase 430
focal adhesion kinase 222
collagenase 200
MEKK1 197
phosphatidylinositol 3-kinase 192
PARP 166
proteasome 158
MAP 153
catalase 153
superoxide dismutase 136
glutathione S-transferase 133
caspase-9 131
IKK 113
caspase-8 111
calcineurin 93
NADPH oxidase 90
NO synthase 90
NADPH oxidase 81
phosphoinositide 3-kinase 78
AMP-activated protein kinase 70
GSK 62
peroxidase 56
phospholipase C 54
thrombin 54
urokinase-type plasminogen activator 51
MMP-3 51
lactate dehydrogenase 50
chloramphenicol acetyltransferase 50
glutathione peroxidase 47
alanine aminotransferase 45
cdc2 44
alkaline phosphatase 43
AMPK 42
RNA polymerase 41
reverse transcriptase 35
heme oxygenase 34
MMP 34
tyrosine hydroxylase 34
CEP 33
CEP 33
caspase-1 33
protein phosphatase 2A 30
ATPase 30
P-glycoprotein 28
aspartate aminotransferase 25
AMPK 25
phospholipase A2 24
gamma-glutamylcysteine synthetase 23
NQO1 23
MIP 22
thymidine kinase 22
interstitial collagenase 21
histone acetyltransferase 20
ornithine decarboxylase 20
myosin light chain kinase 20
renin 19
kinesin 18
APC 18
MPP 18
matrix metalloproteinase 9 17
lipoxygenase 16
glutathione reductase 16
complex I 16
acetylcholinesterase 15
NOS 15
acid phosphatase 14
xanthine oxidase 14
creatine kinase 14
RNase 14
RNase 14
peroxiredoxin 14
topoisomerase 13
caspase-7 13
ACS 12
choline acetyltransferase 12
ECH 12
adenylate cyclase 12
CaMKII 12
caspase-7 12
phosphodiesterase 12
matrix metalloproteinase 2 11
TdT 11
TAT 11
trypsin 11
cathepsin K 10
caspase-4 10
caspase-2 10
topoisomerase 10
beta-galactosidase 10
caspase-4 10
PKG 10
PDK1 10
caspase-2 10
DNase 10
acetyl-CoA carboxylase 10
tissue plasminogen activator 9
guanylate cyclase 9
endonuclease 9
DCF 9
DNA methyltransferase 9
farnesyltransferase 8
prostate-specific antigen 8
farnesyltransferase 8
CYP7A1 8
prostaglandin synthetase 8
NADPH-diaphorase 8
glucose oxidase 8
aldose reductase 7
cathepsin L 7
tyrosinase 7
ACE 7
elastase 7
succinate dehydrogenase 7
phospholipase D 7
glutamine synthetase 7
neutral sphingomyelinase 7
caspase-6 6
ribonucleotide reductase 6
plasmin 6
ribonucleotide reductase 6
glutathione synthetase 6
thioredoxin reductase 6
lysyl oxidase 6
aldehyde dehydrogenase 6
transglutaminase 6
aldehyde dehydrogenase 6
BAL 6
lysozyme 6
aldehyde dehydrogenase 6
aldehyde dehydrogenase 6
glucose-6-phosphate dehydrogenase 6
aldehyde dehydrogenase 6
p100 5
lipase 5
arginase 5
sphingosine kinase 5
TACE 5
hexosaminidase 5
methionine adenosyltransferase 5
cysteine synthase 5
caspase-6 5
3-hydroxy-3-methylglutaryl-CoA reductase 5
cytochrome oxidase 5
CPT 5
firefly luciferase 5
thymidylate synthase 4
CLK1 4
glyceraldehyde-3-phosphate dehydrogenase 4
glyceraldehyde-3-phosphate dehydrogenase 4
prolyl hydroxylase 4
lipoprotein lipase 4
transcriptase 4
papain 4
alcohol dehydrogenase 4
more...
Compound
DNA 2017
NH2 1214
oxygen 894
Dec 827
acetate 467
TNF 429
tyrosine 382
nitric oxide 329
serine 322
calcium 321
glucose 298
ATF 294
MEK 294
cAMP 265
threonine 242
cysteine 201
hydrogen 162
MAP 153
AMP 153
sodium 152
water 152
Clin 138
ATP 137
GSH 133
GSH 133
N-acetylcysteine 130
MTT 125
MDA 112
THP 104
H2O2 104
THP 103
retinoic acid 102
TPA 99
TPA 99
glutamate 91
leucine 89
alanine 84
ethanol 83
PMA 82
PMA 81
phosphate 78
arginine 78
lysine 72
PGE 70
GTP 65
COS 60
dUTP 60
Insulin 59
zinc 58
Ang II 58
sulfate 51
Asp 50
ADP-ribose 50
cadmium 50
potassium 50
Curcumin 49
bromide 47
iodine 45
CAT 43
CAT 43
CAT 43
ADP 42
methionine 41
ADP 40
ADP 40
galactose 40
Cardiol 40
proline 39
nitrogen 39
iron 38
pyrrolidine 37
salt 36
Angiotensin II 35
boron 35
cGMP 34
pyrrolidine 34
Neuronal 32
DDP 31
NMDA 31
APAP 30
NAD 29
PGE2 29
Resveratrol 27
NAD 27
urea 26
Phe 26
Heme 24
glutamine 23
aldehyde 23
MPTP 23
ADR 22
diacetate 21
Wortmannin 21
pyrimidine 21
pyrimidine 21
aspartic acid 20
Genistein 20
selenium 20
Cer 20
Thrombin 20
copper 20
Panam 20
palmitic acid 20
Gly 20
Estrogen 19
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 19
aldehyde 19
pyrene 19
1H-imidazole 19
SDS 18
Dexamethasone 18
MPP 18
MPP 18
FK506 17
aspartic acid 17
manganese 17
Quercetin 17
His 17
SP-1 17
aspartic acid 17
Tanshinone 17
aspartic acid 17
tryptophan 17
DMSO 17
Estrogen 17
Phorbol 16
Adriamycin 16
Estradiol 16
Serine 16
ethyl acetate 16
1H-imidazole 16
NADPH 15
Rapamycin 15
fluorine 15
NADPH 15
nicotinamide 15
Anisomycin 15
vitamin D 15
anthracene 15
nitrate 14
homocysteine 14
ICI 14
Luteolin 14
methanol 14
gallic acid 13
noradrenaline 13
kaempferol 13
adenosylmethionine 13
nickel 12
Tyrosine 12
ACS 12
Berberine 12
ACS 12
superoxide radical 12
Naringin 12
silver 12
methyl methanesulfonate 12
chromium 12
Cycloheximide 12
CO2 12
more...