Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have previously reported that
rhomboid domain containing 1
(
RHBDD1
), a new member of the Rhomboid family, is highly expressed in testis. In the present work, luciferase analyses showed that
RHBDD1
enhanced the AP-1 activity in a dose- and activity-dependent manner.
RHBDD1
overexpression increased
c-Jun
activity, and the activity was visibly inhibited when
RHBDD1
was knocked down. The suppression of
c-Jun
by inactivation of
RHBDD1
was rescued by overexpressing
RHBDD1
. However,
c-Jun
overexpression did not alter the expression level of
RHBDD1
. Furthermore, knockdown of
RHBDD1
led to increased cell apoptosis and reduced expression of Bcl-3. Our findings indicate that
RHBDD1
could inhibit cell apoptosis by activating and upregulating
c-Jun
and its downstream target, Bcl-3.
...
PMID:Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3. 2366 65
