Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
coiled-coil domain containing 50
(
CCDC50
) protein is a phosphotyrosine-dependent signalling protein stimulated by epidermal growth factor. It is highly expressed in neuronal cells in the central nervous system; however, the roles of
CCDC50
in neuronal development are largely unknown. In this study, we showed that the depletion of
CCDC50
-V2 impeded the neuronal development process, including arbor formation, spine density development, and axonal outgrowth, in primary neurons. Mechanistic studies revealed that
CCDC50
-V2 positively regulated the nerve growth factor receptor, while it downregulated the epidermal growth factor receptor pathway. Importantly, JNK/
c-Jun
activation was found to be induced by the
CCDC50
-V2 overexpression, in which the interaction between
CCDC50
-V2 and JNK2 was also observed. Overall, the present study demonstrates a novel mechanism of
CCDC50
function in neuronal development and provides new insight into the link between
CCDC50
function and the aetiology of neurological disorders.
...
PMID:Coiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth. 3327 10
