Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (
MGAT5
) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. The potential anti-cancer effect of Hydrogen Sulfide (H
2
S), has not been widely recognized. It intrigued broad interest to explore the clinical benefits of cancer therapy, with the current understanding of molecular mechanisms of H
2
S which remains very limited. In this study, we identify that H
2
S is an effective inhibitor of
MGAT5
, leading to reduce the expression of exclusively abnormal glycoprotein processes in gastric carcinoma. H
2
S specifically dissociation of karyopherin subunit alpha-2 (KPNA2) with Jun proto-oncogene (
c-Jun
) interaction, and blocking
c-Jun
nuclear translocation, and downregulation of
MGAT5
expression at the level of gene and protein. Consequently, H
2
S impairs growth and metastasis in gastric carcinoma by targeting inhibits
MGAT5
activity. In an animal tumor model study, H
2
S is well tolerated, inhibits gastric carcinoma growth and metastasis. Our preclinical work therefore supports that H
2
S acts as a novel inhibitor of
MGAT5
that block tumorigenesis in gastric carcinoma.
...
PMID:Hydrogen Sulfide Demonstrates Promising Antitumor Efficacy in Gastric Carcinoma by Targeting MGAT5. 2980 Sep 30
