Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Squamous cell carcinoma antigen 1
(
SCCA1
), which belongs to serine proteinase inhibitor (serpin) superfamily, inhibits papain-like cysteine proteinase. Recently, it has been reported that
SCCA1
acts not only as a proteinase inhibitor but also as an inhibitor of UV-induced apoptosis via suppression of the activity of
c-Jun
NH(2)-terminal kinase (JNK1). The present study determined the crystal structure of
SCCA1
, suggesting that the reactive center loop (RCL) of
SCCA1
, a recognition site of proteinase, is very flexible and located away form the main-body of
SCCA1
. We show that the inhibitory effect of
SCCA1
on the kinase activity of JNK1 is lost when the RCL was truncated. Furthermore, we found that a mutant protein created by replacing one amino acid in RCL maintain the suppressive activity to JNK1, whereas the inhibitory effect to proteinase is obviously decreased.
...
PMID:Crystal structure of SCCA1 and insight about the interaction with JNK1. 1916 18
