Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tec is the prototype of an emerging family of protein-tyrosine kinases. Tec and Btk, another member of this family, together participate in the development of B-cell immune system. We previously identified one of the downstream messengers for human Tec kinase,
BRDG1
.
BRDG1
is associated with Tec and becomes tyrosine-phosphorylated in B-cells by the engagement of B-cell antigen receptor (BCR). Here we show that overexpression of
BRDG1
strongly augments BCR-mediated activation of cAMP-response element binding protein (CREB) but not that of
c-Jun
and the promoters of c-MYC and BCL-xL genes. Furthermore, we isolated the murine orthologue of
BRDG1
. Three isoforms of
BRDG1
are generated by alternative splicing of the message. Two of them have a deletion of 33 amino acids in a Pleckstrin homology (PH) domain of
BRDG1
. Both the tyrosine-phosphorylation and CREB-activating ability of
BRDG1
were isoform-dependent, suggesting a role of the PH domain of
BRDG1
. These data have identified a novel regulatory mechanism of CREB family of transcriptional factors.
...
PMID:Isoform-dependent interaction of BRDG1 with Tec kinase. 1171 89
