Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
c-Jun
is a member of the AP-1 family of transcription factors regulating expression of specific target genes in a variety of cellular processes including proliferation, stress response, and tumorigenicity. In the present study we have analyzed the mechanism of
c-Jun
function as a transactivator with respect to members of the basal transcription machinery, TATA-binding protein-associated factors (TAFs). We show that one member of the family, human
TAF7
(formerly TAFII55), physically interacts with
c-Jun
through two independent interaction domains, within the N- and C-terminal part of
c-Jun
. Interaction in vitro correlates with enhanced transactivation function of
c-Jun
in HEK293 and COS cells in the presence of increasing amounts of
TAF7
.
TAF7
interacts preferentially with DNA-bound phosphorylated
c-Jun
, suggesting that
TAF7
represents a novel
c-Jun
co-activator mediating activation of AP-1 target genes in response to extracellular signals.
...
PMID:TAF7 (TAFII55) plays a role in the transcription activation by c-Jun. 1267 57
