Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of
Batroxobin
on expression of
c-Jun
in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats, and at the same time
c-Jun
expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of
Batroxobin
-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of
c-Jun
immune reactive cells of
Batroxobin
-treated rats was also less than that of ischemic group. In conclusion,
Batroxobin
can improve spatial memory disorder in temporal ischemic rats, and the down-regulation of the expression of
c-Jun
is probably related to the neuroprotective mechanism.
...
PMID:Effect of batroxobin on expression of c-Jun in left temporal ischemic rats with spatial learning and memory disorder. 1103 9
