Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UNIPROT:P05412 (c-Jun)
11,453 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

HBZ is expressed by the complex retrovirus, Human T-cell Leukemia Virus type 1, and implicated in pathological effects associated with viral infection. From the nucleus, HBZ alters gene expression by interacting with a variety of transcriptional regulatory proteins, among which is c-Jun. Previously, one of the three HBZ variants, HBZ_US, was reported to decrease c-Jun expression by promoting its degradation. Here we show that another variant, HBZ_S1, produces the opposite effect. In the presence of HBZ_S1, c-Jun expression increases due to its stabilization. Our data suggest that this effect requires the ability of HBZ_S1 to interact with c-Jun. We provide evidence that HBZ_S1 inhibits the proteosomal degradation of c-Jun initiated by the Cop1-containing ubiquitin ligase complex. HBZ_S1 is the most abundant variant in HTLV-1-infected T-cells, and our data indicate that levels of c-Jun expression in infected cells are consistent with effects of HBZ_S1.
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PMID:The splice 1 variant of HTLV-1 bZIP factor stabilizes c-Jun. 3284 59


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