Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05412 (
c-Jun
)
11,453
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Jun activation domain-binding protein 1 (Jab1) is a coactivator of activating protein-1 (AP-1) and is the fifth component of the COP9 signalosome complex. It interacts with a variety of proteins and plays important roles in diverse signaling pathways and cellular function including oncogenesis. We show here that Jab1 interacts in vivo with
nuclear receptor binding protein
(
NRBP
), an evolutionarily conserved adapter protein with a kinase-like domain. We further show that
NRBP
inhibits Jab1-induced phosphorylation of
c-Jun
and AP-1 activation. Finally, overexpression of
NRBP
in mammalian cells specifically inhibits AP-1 activation by various stimuli. Taken together, our data suggest that
NRBP
may be an important negative regulator of Jab1-mediated functions such as gene transcription and tumor progression.
...
PMID:Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. 1705 10
