Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UNIPROT:P05231 (interleukin-6)
23,907 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein interleukin-6 23907 tumor necrosis factor 6485 cytokine 5965 TNF 3118 lipopolysaccharide 2456 C-reactive protein 2194 Sep 1620 IL-6 1337 Mol 1228 tumor necrosis factor alpha 1223 insulin 1070 interferon 852 inducible nitric oxide synthase 764 interferon-gamma 680 interleukin-10 679 STAT3 674 cyclooxygenase-2 668 gp130 658 superoxide dismutase 628 IL-8 607 Cytokine 598 p65 573 p38 569 collagen 535 vascular endothelial growth factor 515 leptin 491 IL-10 490 TLR4 480 IL-1 beta 476 monocyte chemoattractant protein-1 463 adiponectin 463 LPS 456 IL-1 440 IFN 416 myeloperoxidase 411 interleukin-2 407 fibrinogen 406 signal transducer and activator of transcription 3 397 TNF-alpha 386 chemokine 353 caspase-3 350 catalase 339 albumin 338 CRP 318 intercellular adhesion molecule-1 317 CD4 312 GSH 306 MAPK 299 STAT 293 glutathione peroxidase 289 interleukin-4 288 granulocyte 279 glycoprotein 278 leukemia inhibitory factor 273 granulocyte-macrophage colony-stimulating factor 256 lactate dehydrogenase 248 matrix metalloproteinase 246 nitric oxide synthase 244 alkaline phosphatase 244 Bcl-2 243 Leukemia inhibitory factor 241 alanine aminotransferase 240 aspartate aminotransferase 237 mitogen-activated protein 231 IL6 229 Tumor necrosis factor 229 granulocyte colony-stimulating factor 227 ERK1 226 JNK 218 CD8 218 hemoglobin 217 transforming growth factor-beta 217 ERK 210 macrophage colony-stimulating factor 206 gut 203 vascular cell adhesion molecule-1 202 adhesion molecule 202 monocyte chemotactic protein 201 heme oxygenase-1 201 extracellular signal-regulated kinase 196 more...

Disease cancer 1799 tumor 1550 obesity 766 diabetes 724 sepsis 654 sepsis 636 multiple myeloma 626 rheumatoid arthritis 610 atherosclerosis 609 cardiovascular disease 414 hypertension 398 depression 389 arthritis 372 hepatocellular carcinoma 363 ischemia 350 type 2 diabetes 338 GSH 306 Alzheimer's disease 302 leukemia 285 stroke 274 tumor growth 272 breast cancer 262 HIV 226 metabolic syndrome 225 lymphoma 217 myocardial infarction 215 carcinoma 203 infectious diseases 202 heart failure 194 prostate cancer 194 anemia 193 virus infection 191 plaque 185 osteoporosis 181 tumorigenesis 174 osteoarthritis 173 colitis 173 immunodeficiency 171 pneumonia 169 carcinogenesis 166 tumor progression 161 coronary artery disease 160 inflammatory bowel disease 154 systemic lupus erythematosus 152 Kaposi's sarcoma 145 coronary heart disease 145 hyperglycemia 142 influenza 139 renal disease 135 asthma 132 multiple sclerosis 131 lung cancer 130 bacterial infection 129 thrombocytopenia 127 AIDS 125 chronic obstructive pulmonary disease 123 autoimmune disease 121 melanoma 119 Castleman's disease 118 Infection 114 acute pancreatitis 112 periodontitis 112 SARS 112 cognitive impairment 111 fatty liver 109 cirrhosis 108 Parkinson's disease 107 liver disease 104 adenocarcinoma 102 metastases 102 colorectal cancer 102 cold 100 B-cell lymphoma 99 lymphadenopathy 97 cerebral ischemia 97 ulcerative colitis 97 psoriasis 94 Epstein 92 tuberculosis 90 Mycobacterium 89 more...

Symptom pain 404 fatigue 155 cachexia 146 anesthesia 129 overweight 125 respiratory distress 108 seizures 82 anorexia 75 diarrhea 62 hypothermia 56 headache 46 exhaustion 46 cough 44 angina 41 splenomegaly 41 arthralgia 35 collapse 34 myalgia 32 functional recovery 31 starvation 29 abdominal pain 29 analgesia 28 hyperoxia 27 acute stress 27 nausea 26 vomiting 26 erythema 26 weakness 25 hepatosplenomegaly 24 sleepiness 24 dyspnea 23 chills 18 Neuropathic pain 18 skin damage 17 Ill 15 insomnia 15 lethargy 14 bone pain 12 back pain 10 thinning 10 low back pain 9 chest pain 9 night sweats 9 Depressive symptoms 8 despair 8 hypercapnia 8 hepatomegaly 8 discomfort 8 shortness of breath 8 constipation 7 dry eye 7 hunger 7 hemiplegia 7 nausea and vomiting 6 tremor 6 acute pain 6 discomfort 6 acidity 6 pelvic pain 6 menopausal symptoms 5 skin irritation 5 memory loss 5 fever of unknown origin 5 HSA 5 asthenia 5 sore throat 5 snoring 5 swollen joints 4 agitation 4 exertional dyspnea 4 decreased appetite 4 mental fatigue 4 Muscle soreness 4 lassitude 4 sciatica 4 rigors 4 spasm 3 Gastrointestinal symptoms 3 flushing 3 apathy 3 more...

Drug CSF 244 IL-2 173 Tocilizumab 143 Dermatol 140 IFN-gamma 137 Cardiovasc 116 IL-11 81 ROS 70 Monit 61 lysine 58 IFN-beta 52 ascorbate 52 Dial 50 G-CSF 48 vitamin E 47 Gel 42 MAP 40 Angiotensin II 32 PTH 30 p75 29 Bifidobacterium 27 Indomethacin 25 ROC 24 Simvastatin 24 Nephron 23 CTX 22 ICI 21 Heme 20 Ethanol 20 Histamine 19 caffeine 18 Albumin 18 EPA 17 CCL 16 IL-1ra 16 Nephron 13 Glutathione 13 CTX 13 Nitric Oxide 13 Estrogens 13 TAK 13 CTX 13 ZnO 13 Bortezomib 13 Retinoic acid 12 DNase I 12 CAM 12 Rituximab 12 EE2 11 Infliximab 11 Asn 11 Propofol 11 Infliximab 11 ampicillin 10 Methylprednisolone 10 ABC 10 Glucagon 10 Prednisolone 10 nitroglycerin 10 Leaf 9 Emodin 9 Emodin 9 G418 9 Rosiglitazone 9 NADH 9 Asthma 8 Vitamin E 8 TTC 8 ALA 8 DEX 8 Activin 8 Fluorescein 8 Forskolin 8 Lovastatin 8 ETS 8 Spectrum 8 Serum albumin 8 Growth hormone 7 Adriamycin 7 Portal 7 more...

Enzyme mitogen-activated protein kinase 1173 superoxide dismutase 668 peroxidase 473 catalase 356 alanine aminotransferase 336 protein kinase 311 ERK 308 focal adhesion kinase 301 glutathione peroxidase 291 caspase-3 286 aspartate aminotransferase 277 lactate dehydrogenase 273 alkaline phosphatase 244 luciferase 235 protein kinase C 214 creatine kinase 191 reverse transcriptase 156 NO synthase 154 collagenase 143 thrombin 142 MEK 129 AMP-activated protein kinase 106 IKK 95 renin 85 proteasome 84 MIP 80 RNA polymerase 79 phosphatidylinositol 3-kinase 76 phospholipase A2 70 NADPH oxidase 66 elastase 66 trypsin 65 transcriptase 64 NADPH oxidase 63 glutathione reductase 58 acetylcholinesterase 55 MMP-3 54 APC 51 tissue plasminogen activator 50 glutathione S-transferase 50 ACS 49 chloramphenicol acetyltransferase 49 caspase-9 48 caspase-1 48 neutrophil elastase 46 caspase-8 45 phospholipase C 45 heme oxygenase 45 RNase 44 RNase 44 AMPK 41 lipoprotein lipase 41 phosphodiesterase 40 AMPK 39 AST 38 urokinase-type plasminogen activator 38 GSK 37 thromboplastin 37 ATPase 37 lipase 36 ACE 36 arginase 35 prostate-specific antigen 34 adenylate cyclase 34 lysozyme 34 MAP 32 ceruloplasmin 32 plasmin 32 calcineurin 31 gamma-glutamyl transpeptidase 30 phosphoinositide 3-kinase 30 tyrosine hydroxylase 29 NOS 29 xanthine oxidase 29 PARP 28 NQO1 27 MMP 23 CD10 23 lipoxygenase 22 matrix metalloproteinase 9 22 more...

Compound TNF 3118 Dec 1657 nitric oxide 1239 DNA 1222 Clin 1100 glucose 1020 oxygen 1008 water 462 calcium 454 tyrosine 386 sodium 361 acetate 332 GSH 314 GSH 314 creatinine 303 iron 264 ethanol 241 sulfate 221 urea 218 phosphate 202 nitrogen 194 PGE 179 Cardiol 178 THP 174 arginine 173 THP 171 cAMP 171 serine 138 zinc 131 MTT 131 hydrogen 122 MDA 120 galactose 117 AMP 117 Insulin 116 cysteine 108 ATP 99 glutamate 97 alanine 96 vitamin D 94 retinoic acid 93 lysine 91 leucine 90 PGE2 90 ACTH 81 tryptophan 80 silver 79 methionine 79 Tumor Necrosis Factor 77 titanium 77 homocysteine 76 tryptophan 73 tryptophan 72 nitrate 72 tryptophan 72 MEK 71 dUTP 67 Dexamethasone 64 CO2 64 neopterin 62 Phe 62 His 61 potassium 60 noradrenaline 60 acetic acid 59 salt 59 PEG 58 copper 58 NH2 56 bromide 55 glutamine 55 Curcumin 54 SDS 52 N-acetylcysteine 51 ACS 49 ACS 49 Dial 49 Ang II 49 threonine 48 hyaluronic acid 47 more...

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