Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P05231 (interleukin-6)
 23,907 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
interleukin-6 23907
tumor necrosis factor 6485
cytokine 5965
TNF 3118
lipopolysaccharide 2456
C-reactive protein 2194
Sep 1620
IL-6 1337
Mol 1228
tumor necrosis factor alpha 1223
insulin 1070
interferon 852
inducible nitric oxide synthase 764
interferon-gamma 680
interleukin-10 679
STAT3 674
cyclooxygenase-2 668
gp130 658
superoxide dismutase 628
IL-8 607
Cytokine 598
p65 573
p38 569
collagen 535
vascular endothelial growth factor 515
leptin 491
IL-10 490
TLR4 480
IL-1 beta 476
adiponectin 463
monocyte chemoattractant protein-1 463
LPS 456
IL-1 440
IFN 416
myeloperoxidase 411
interleukin-2 407
fibrinogen 406
signal transducer and activator of transcription 3 397
TNF-alpha 386
chemokine 353
caspase-3 350
catalase 339
albumin 338
CRP 318
intercellular adhesion molecule-1 317
CD4 312
GSH 306
MAPK 299
STAT 293
glutathione peroxidase 289
interleukin-4 288
granulocyte 279
glycoprotein 278
leukemia inhibitory factor 273
granulocyte-macrophage colony-stimulating factor 256
lactate dehydrogenase 248
matrix metalloproteinase 246
alkaline phosphatase 244
nitric oxide synthase 244
Bcl-2 243
Leukemia inhibitory factor 241
alanine aminotransferase 240
aspartate aminotransferase 237
mitogen-activated protein 231
Tumor necrosis factor 229
IL6 229
granulocyte colony-stimulating factor 227
ERK1 226
CD8 218
JNK 218
hemoglobin 217
transforming growth factor-beta 217
ERK 210
macrophage colony-stimulating factor 206
gut 203
adhesion molecule 202
vascular cell adhesion molecule-1 202
monocyte chemotactic protein 201
heme oxygenase-1 201
extracellular signal-regulated kinase 196
CSF 191
CD14 189
fibronectin 186
oncostatin M 182
TLR2 178
lymphoid 177
IL-1 alpha 174
IL-2 172
p38 mitogen-activated protein kinase 172
erythroid 172
THP 170
plasminogen activator inhibitor-1 169
creatine kinase 168
insulin-like growth factor 168
erythropoietin 166
c-Jun 165
glial fibrillary acidic protein 162
IL-4 161
interferon gamma 156
STAT1 152
ciliary neurotrophic factor 152
resistin 151
sIL-6R 151
stem cell factor 150
p53 150
epidermal growth factor 148
serum amyloid A 147
Janus kinase 144
IFN-gamma 144
tyrosine kinase 143
brain-derived neurotrophic factor 143
MCP-1 142
ICAM-1 142
thrombin 142
AP-1 140
JAK2 138
hepatocyte growth factor 137
E-selectin 136
AKT 135
ferritin 134
cyclooxygenase 134
osteocalcin 133
peroxisome proliferator-activated receptor 132
IgA 129
interleukin-1 receptor antagonist 128
serum albumin 126
CCL2 123
TNF receptor 122
haptoglobin 122
HDL 120
RANTES 116
endothelin-1 115
COX-2 114
endoplasmic reticulum 113
angiotensin II 112
CD11b 111
PI3K 109
growth hormone 108
CD40 108
MMP-9 107
mTOR 107
membrane-bound 107
nerve growth factor 106
AMP 106
GM-CSF 103
p50 103
monocyte chemoattractant protein 103
IL-3 103
platelet-derived growth factor 101
interferon-alpha 100
beta-endorphin 100
TGF-beta 99
ATP 99
parathyroid hormone 97
tissue factor 97
mast cell 96
interleukin-2 receptor 95
IL-17 94
adipokine 92
cytokine receptor 92
more...
Disease
cancer 1799
tumor 1550
obesity 766
diabetes 724
sepsis 654
sepsis 636
multiple myeloma 626
rheumatoid arthritis 610
atherosclerosis 609
cardiovascular disease 414
hypertension 398
depression 389
arthritis 372
hepatocellular carcinoma 363
ischemia 350
type 2 diabetes 338
GSH 306
Alzheimer's disease 302
leukemia 285
stroke 274
tumor growth 272
breast cancer 262
HIV 226
metabolic syndrome 225
lymphoma 217
myocardial infarction 215
carcinoma 203
infectious diseases 202
heart failure 194
prostate cancer 194
anemia 193
virus infection 191
plaque 185
osteoporosis 181
tumorigenesis 174
colitis 173
osteoarthritis 173
immunodeficiency 171
pneumonia 169
carcinogenesis 166
tumor progression 161
coronary artery disease 160
inflammatory bowel disease 154
systemic lupus erythematosus 152
Kaposi's sarcoma 145
coronary heart disease 145
hyperglycemia 142
influenza 139
renal disease 135
asthma 132
multiple sclerosis 131
lung cancer 130
bacterial infection 129
thrombocytopenia 127
AIDS 125
chronic obstructive pulmonary disease 123
autoimmune disease 121
melanoma 119
Castleman's disease 118
Infection 114
periodontitis 112
acute pancreatitis 112
SARS 112
cognitive impairment 111
fatty liver 109
cirrhosis 108
Parkinson's disease 107
liver disease 104
adenocarcinoma 102
colorectal cancer 102
metastases 102
cold 100
B-cell lymphoma 99
cerebral ischemia 97
ulcerative colitis 97
lymphadenopathy 97
psoriasis 94
Epstein 92
tuberculosis 90
Crohn's disease 89
Mycobacterium 89
peritonitis 88
dementia 87
schizophrenia 87
renal cell carcinoma 86
squamous cell carcinoma 84
multicentric Castleman's disease 84
major depressive disorder 83
myocardial ischemia 82
vasculitis 81
MIP 80
hyperlipidemia 79
pancreatitis 77
acute myocardial infarction 77
Leukemia 75
malnutrition 74
glioma 72
dyslipidemia 71
colon cancer 71
glucose intolerance 69
cytomegalovirus 68
encephalopathy 67
renal failure 67
Blocking 66
diabetic nephropathy 66
ovarian cancer 65
hepatitis B 65
SEM 64
hepatitis 63
thrombocytosis 63
chronic hepatitis 63
malaria 62
gastric cancer 62
lupus 62
glomerulonephritis 60
liver fibrosis 59
encephalitis 59
periodontal disease 59
encephalomyelitis 59
astrocytoma 59
chronic disease 58
SCID 58
pulmonary edema 58
Mycoplasma 57
psychological stress 57
Tumour necrosis 57
plasmacytoma 55
MCF 55
meningitis 55
non-small cell lung cancer 54
osteosarcoma 54
neuroblastoma 54
chronic renal failure 54
acute myeloid leukemia 53
pancreatic cancer 53
proteinuria 52
glioblastoma 51
PSS 51
congestive heart failure 51
vascular disease 51
SDS 50
chronic pain 50
Hodgkin's disease 49
wasting 49
bacteremia 47
preeclampsia 46
cystic fibrosis 46
epilepsy 46
herpes 46
muscular atrophy 45
NAME 45
lupus 44
neutropenia 44
herpes simplex 44
hypercalcemia 44
heart disease 43
neuropathy 43
liver cancer 43
hyperinsulinemia 43
pulmonary fibrosis 42
more...
Symptom
pain 404
fatigue 155
cachexia 146
anesthesia 129
overweight 125
respiratory distress 108
seizures 82
anorexia 75
diarrhea 62
hypothermia 56
headache 46
exhaustion 46
cough 44
angina 41
splenomegaly 41
arthralgia 35
collapse 34
myalgia 32
functional recovery 31
starvation 29
abdominal pain 29
analgesia 28
acute stress 27
hyperoxia 27
nausea 26
erythema 26
vomiting 26
weakness 25
hepatosplenomegaly 24
sleepiness 24
dyspnea 23
chills 18
Neuropathic pain 18
skin damage 17
Ill 15
insomnia 15
lethargy 14
bone pain 12
back pain 10
thinning 10
low back pain 9
chest pain 9
night sweats 9
despair 8
shortness of breath 8
discomfort 8
Depressive symptoms 8
hepatomegaly 8
hypercapnia 8
dry eye 7
hemiplegia 7
hunger 7
constipation 7
acidity 6
nausea and vomiting 6
pelvic pain 6
tremor 6
acute pain 6
discomfort 6
memory loss 5
HSA 5
asthenia 5
menopausal symptoms 5
sore throat 5
fever of unknown origin 5
skin irritation 5
snoring 5
exertional dyspnea 4
Muscle soreness 4
mental fatigue 4
sciatica 4
decreased appetite 4
agitation 4
lassitude 4
swollen joints 4
rigors 4
dizziness 3
spasm 3
syncope 3
paresthesia 3
tinnitus 3
flushing 3
tachypnea 3
disturbed balance 3
polyuria 3
Wind 3
ataxia 3
distraction 3
POA 3
numbness 3
apathy 3
acute abdomen 3
Gastrointestinal symptoms 3
oliguria 3
nasal congestion 3
clubbing 3
Stiffness 2
intestinal bleeding 2
dysarthria 2
alexithymia 2
bladder pain 2
neurological disability 2
spasticity 2
Flu-like symptoms 2
Hangover 2
joint stiffness 2
vertigo 2
orofacial pain 2
neuralgia 2
consciousness disturbance 2
autodigestion 2
hypocapnia 2
shoulder pain 2
hangover 2
physical exhaustion 2
Tenderness 2
abdominal discomfort 2
incoordination 2
polydipsia 2
photophobia 2
cancer pain 2
nasal discharge 2
limb pain 2
persistent cough 2
Pancreatic pain 1
Postoperative pain 1
adenitis 1
Afebrile convulsion 1
throat irritation 1
pallor 1
loss of taste 1
sinus pain 1
scaly skin 1
dysuria 1
hopelessness 1
polymyalgia 1
Genitourinary pain 1
bradykinesia 1
blurred vision 1
paresis 1
Spots 1
Positive and Negative Symptoms 1
anosmia 1
flank pain 1
Severe diarrhea 1
productive cough 1
male subfertility 1
painful erections 1
hypersomnia 1
eds 1
acute low back pain 1
knee pain 1
feeling of malaise 1
Cancer Fatigue 1
hypotonia 1
Stable angina pectoris 1
rectal pain 1
renal pain 1
blepharospasm 1
wheezing 1
more...
Drug
CSF 244
IL-2 173
Tocilizumab 143
Dermatol 140
IFN-gamma 137
Cardiovasc 116
IL-11 81
ROS 70
Monit 61
lysine 58
ascorbate 52
IFN-beta 52
Dial 50
G-CSF 48
vitamin E 47
Gel 42
MAP 40
Angiotensin II 32
PTH 30
p75 29
Bifidobacterium 27
Indomethacin 25
Simvastatin 24
ROC 24
Nephron 23
CTX 22
ICI 21
Heme 20
Ethanol 20
Histamine 19
caffeine 18
Albumin 18
EPA 17
CCL 16
IL-1ra 16
Estrogens 13
Nephron 13
Bortezomib 13
CTX 13
Nitric Oxide 13
CTX 13
TAK 13
Glutathione 13
ZnO 13
DNase I 12
CAM 12
Rituximab 12
Retinoic acid 12
Asn 11
Infliximab 11
Infliximab 11
Propofol 11
EE2 11
Methylprednisolone 10
ABC 10
ampicillin 10
Glucagon 10
nitroglycerin 10
Prednisolone 10
Leaf 9
Rosiglitazone 9
G418 9
Emodin 9
NADH 9
Emodin 9
Lovastatin 8
Asthma 8
Vitamin E 8
Fluorescein 8
ETS 8
Activin 8
Spectrum 8
Forskolin 8
TTC 8
ALA 8
DEX 8
Serum albumin 8
Growth hormone 7
lactose 7
TAT 7
ETA 7
Adriamycin 7
MRC 7
Portal 7
Growth hormone 7
Ginseng 7
niacin 6
Mutagen 6
Adenosine triphosphate 6
TiO2 6
Aloe 6
Tenidap 6
Parkin 6
ADM 6
Azithromycin 6
Abatacept 6
Ringer's solution 6
Parkin 6
Silica 6
Lenalidomide 6
Fraction 5
Anakinra 5
Oxaliplatin 5
Spectrum 5
Valsartan 5
NVP 5
Glycyrrhiza 5
Imiquimod 5
Arsenic trioxide 5
Adenosine deaminase 5
Epigallocatechin 4
Sorafenib 4
R1881 4
HCG 4
balanced salt solution 4
Liraglutide 4
Hypaque 4
Olive oil 4
Ulinastatin 4
Sodium nitroprusside 4
Nimesulide 4
Rosuvastatin 4
Hypaque 4
VCR 4
Meth 4
Paraffin 4
uPA 4
Zoledronic acid 4
ACT 4
ENT 4
Campath 3
CIA 3
Photofrin 3
DPA 3
BLyS 3
Limonene 3
Galactose 3
Rutin 3
DMI 3
Maraviroc 3
-deoxyadenosine 3
Ganciclovir 3
Gelatin 3
Pravastatin 3
Icodextrin 3
CPR 3
Zileuton 3
E5564 3
Omeprazole 3
Fructose 3
Tacrolimus 3
Imatinib 3
Gabexate mesilate 3
Alanine 3
TAC 3
Olmesartan 3
Florfenicol 3
Fluorescein 3
Vitamin K 3
Troglitazone 3
more...
Enzyme
mitogen-activated protein kinase 1173
superoxide dismutase 668
peroxidase 473
catalase 356
alanine aminotransferase 336
protein kinase 311
ERK 308
focal adhesion kinase 301
glutathione peroxidase 291
caspase-3 286
aspartate aminotransferase 277
lactate dehydrogenase 273
alkaline phosphatase 244
luciferase 235
protein kinase C 214
creatine kinase 191
reverse transcriptase 156
NO synthase 154
collagenase 143
thrombin 142
MEK 129
AMP-activated protein kinase 106
IKK 95
renin 85
proteasome 84
MIP 80
RNA polymerase 79
phosphatidylinositol 3-kinase 76
phospholipase A2 70
NADPH oxidase 66
elastase 66
trypsin 65
transcriptase 64
NADPH oxidase 63
glutathione reductase 58
acetylcholinesterase 55
MMP-3 54
APC 51
glutathione S-transferase 50
tissue plasminogen activator 50
chloramphenicol acetyltransferase 49
ACS 49
caspase-9 48
caspase-1 48
neutrophil elastase 46
phospholipase C 45
caspase-8 45
heme oxygenase 45
RNase 44
RNase 44
lipoprotein lipase 41
AMPK 41
phosphodiesterase 40
AMPK 39
AST 38
urokinase-type plasminogen activator 38
thromboplastin 37
ATPase 37
GSK 37
lipase 36
ACE 36
arginase 35
prostate-specific antigen 34
lysozyme 34
adenylate cyclase 34
plasmin 32
ceruloplasmin 32
MAP 32
calcineurin 31
phosphoinositide 3-kinase 30
gamma-glutamyl transpeptidase 30
xanthine oxidase 29
tyrosine hydroxylase 29
NOS 29
PARP 28
NQO1 27
CD10 23
MMP 23
lipoxygenase 22
acid phosphatase 22
matrix metalloproteinase 9 22
cholinesterase 21
tryptase 20
beta-galactosidase 19
ribonuclease 19
ribonuclease 19
acetyl-CoA carboxylase 16
hexosaminidase 16
paraoxonase 16
thyroid peroxidase 16
cdc2 16
transglutaminase 16
paraoxonase 16
thymidine kinase 16
endonuclease 15
indoleamine 2,3-dioxygenase 15
cathepsin K 15
glyceraldehyde-3-phosphate dehydrogenase 14
neuraminidase 13
phosphoenolpyruvate carboxykinase 13
P-glycoprotein 13
CYP3A4 13
pepsin 12
CD13 12
interstitial collagenase 12
chymase 12
cathepsin B 12
phosphoenolpyruvate carboxykinase 12
prostaglandin synthetase 12
phosphoenolpyruvate carboxykinase 12
kallikrein 12
glyceraldehyde-3-phosphate dehydrogenase 12
phospholipase D 11
glucose-6-phosphatase 11
choline acetyltransferase 11
monoamine oxidase 11
aldehyde dehydrogenase 10
glyceraldehyde-3-phosphate dehydrogenase 10
diamine oxidase 10
glyceraldehyde-3-phosphate dehydrogenase 10
gamma-glutamylcysteine synthetase 10
cathepsin G 10
protein phosphatase 2A 10
CPT 10
matrix metalloproteinase 2 10
glyceraldehyde-3-phosphate dehydrogenase 10
adenosine deaminase 10
citrate synthase 10
adenosine deaminase 10
enolase 9
thioredoxin reductase 9
DNA methyltransferase 9
aldehyde dehydrogenase 9
DNase 9
demethylase 8
15-lipoxygenase 8
MPP 8
dihydrofolate reductase 8
aldehyde dehydrogenase 8
hormone-sensitive lipase 8
aldehyde dehydrogenase 8
TACE 8
proteinase K 8
PRE 8
ornithine decarboxylase 8
BAL 8
cathepsin D 8
aldehyde dehydrogenase 8
Thy1 8
hyaluronidase 8
succinate dehydrogenase 8
hyaluronidase 8
factor C 7
soluble epoxide hydrolase 7
CAD 7
3-hydroxy-3-methylglutaryl coenzyme A reductase 7
TAT 7
MEKK1 7
CAD 7
CAD 7
more...
Compound
TNF 3118
Dec 1657
nitric oxide 1239
DNA 1222
Clin 1100
glucose 1020
oxygen 1008
water 462
calcium 454
tyrosine 386
sodium 361
acetate 332
GSH 314
GSH 314
creatinine 303
iron 264
ethanol 241
sulfate 221
urea 218
phosphate 202
nitrogen 194
PGE 179
Cardiol 178
THP 174
arginine 173
cAMP 171
THP 171
serine 138
zinc 131
MTT 131
hydrogen 122
MDA 120
AMP 117
galactose 117
Insulin 116
cysteine 108
ATP 99
glutamate 97
alanine 96
vitamin D 94
retinoic acid 93
lysine 91
leucine 90
PGE2 90
ACTH 81
tryptophan 80
silver 79
methionine 79
Tumor Necrosis Factor 77
titanium 77
homocysteine 76
tryptophan 73
tryptophan 72
nitrate 72
tryptophan 72
MEK 71
dUTP 67
CO2 64
Dexamethasone 64
neopterin 62
Phe 62
His 61
noradrenaline 60
potassium 60
acetic acid 59
salt 59
PEG 58
copper 58
NH2 56
glutamine 55
bromide 55
Curcumin 54
SDS 52
N-acetylcysteine 51
Dial 49
ACS 49
ACS 49
Ang II 49
threonine 48
hyaluronic acid 47
aldosterone 46
iodine 44
Cortisol 44
8-OHdG 44
pyrrolidine 44
5-HT 44
nicotinamide 43
CCl4 43
Angiotensin II 42
NAD 41
PMA 39
pyrrolidine 39
TSH 39
H2O2 39
ASA 38
selenium 38
COS 36
PMA 36
Hematoxylin 35
NAD 35
ADP 34
Pac 34
aldehyde 34
DHA 34
palmitic acid 33
PEG 33
cobalt 33
methanol 33
Resveratrol 33
MAP 33
DBA 33
prostacyclin 32
aldehyde 30
proline 30
retinol 30
DBA 29
Estrogen 29
DBA 29
glycerol 29
Estrogen 29
GSSG 29
Cereb 28
ethyl acetate 28
Interleukin-2 28
cadmium 27
APAP 27
STZ 27
aluminum 26
phosphorus 26
Thyroid 26
CAT 25
TOF 25
cGMP 25
Thrombin 25
CAT 25
Fibrinogen 25
CAT 25
nickel 25
palmitic acid 24
methane 23
GABA 23
Asp 23
Methotrexate 23
Malondialdehyde 23
GABA 23
ammonium 22
CTX 22
TPA 22
TPA 22
prostaglandin E1 22
gallic acid 22
Indomethacin 21
adenylate 21
ICI 21
Cyclosporine 21
Tyrosine 21
Adriamycin 21
ADP 21
NMDA 21
Heme 20
more...