Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P05231 (interleukin-6)
 23,907 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Transforming growth factor-beta (TGF beta 1), a multipotent immunoregulatory peptide produced by human platelets, has been shown to stimulate the synthesis of fibrinogen, contrapsin, complement component C3, and alpha-1-proteinase inhibitor by murine hepatocytes cultured for 2 days in DMEM containing 1 microM insulin and dexamethasone and 0.2% BSA. In the range of 10 pg to 10 ng/ml TGF-beta 1 did not elicit any change in albumin secretion. Two main inflammatory cytokines: interleukin-6 (IL-6) and interleukin-1 (IL-1), known to stimulate two different subsets of murine acute phase plasma proteins, failed to increase contrapsin and alpha-1-proteinase inhibitor production. Epidermal growth factor (EGF) in the concentration 1 ng to 10 ng/ml effectively counteracted the stimulatory effect of TGF-beta 1 on acute phase protein production. TGF-beta 1-induced fibrinogen protein levels were associated with increased beta-fibrinogen mRNA content. TGF-beta 1 appears to be an additional physiological factor responsible for the direct stimulation of normal mouse hepatocytes to acute phase response.
Acta Biochim Pol 1991
PMID:Regulation of acute phase reaction by transforming growth factor beta in cultured murine hepatocytes. 172 35

The stimulation of platelets production by human hemopoietic growth factors, became an interesting alternative in the treatment of thrombocytopenic patients. Because the lineage specific Colony Stimulating Factor of Megakaryocytes (CSF-Meg) has not yet been discovered, the aim of our study was to compare the stimulatory potential of different hemopoietic growth factors influencing megakaryocytic colony formation in vitro. According to our results the best strategy to stimulate human megakaryocytopoiesis in vivo seems to be simultaneous or sequential use of the mixture of several cytokines including: interleukin-3, interleukin-6, erythropoietin or kit ligand. The best stimulatory effect we have obtained however, using recently developed by molecular biology means recombinant fusion protein composed of joined by peptide bridge interleukin-3 and erythropoietin molecules. The data presented in this paper, could find application in the near future by elaborating more effective clinical protocols for treatment of thrombocytopenia using hemopoietic growth factors.
Pol Arch Med Wewn 1994 May
PMID:[Stimulation of human megakaryopoiesis in vitro with different growth factors. Potential clinical applications]. 808 12

In the past decade, cytokines came into focus as important multifunctional mediators regulating cellular functioning and intercellular connections. Particular cytokines may both inhibit and stimulate cells playing an important role in maintaining homeostasis of the normal tissue. In the majority of pathologies not individual cytokines but their complexes are involved. Numerous studies on cytokines are mainly aimed at evaluating the role of the following cytokines in pulmonary diseases: tumour necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), insulin-like growth factor I (IGF-I), interleukin-1 (IL-1), and recently interleukin-6 (IL-6). The possible physiologic significance and role of cytokines in lung diseases are surveyed.
Pol Tyg Lek
PMID:[Biological properties of cytokines and their role in lung pathology]. 841 54

We have observed that acute myocardial infarction is associated with the immunological response characterized a transient rise of serum immunoglobulin E (IgE). We wondered whether this reaction was specific for myocardial infarction or whether it reflected a more generalized phenomenon, perhaps triggered by tissue injury. We, therefore, made a large prospective study on patients undergoing various surgical procedures. These were the patients undergoing coronary artery bypass graft, who did (n = 39) or did not (n = 42) develop perioperative myocardial infarction, patients subjected to thoracic operations (n = 33) patients having cholecystectomy (n = 17) or repair of the inguinal hernia (n = 18) and 30 healthy volunteers forming the control group. Blood samples were drawn before the operation and then after the operation at 8, 16, 24, 48, 72, 120, 168 and 216 hours. In all samples, concentrations of serum immunoglobulins E were determined on blinded specimens by an automated microparticle enzyme immunoassay while immunoglobulins G, A and M were determined using nephelometry. In all groups studied, except the control group, serum IgE began to rise shortly after the operations reached a peak by the fifth day, and then gradually declined. This behaviour of IgE serum levels was in striking contrast to that of the remaining serum immunoglobulins G, A and M which showed a rapid fall after surgical interventions, followed by a gradual return to the initial values. The stimulation of hypothalamus-adrenal axis and release of glucocorticosteroids, interacting with de novo synthesized interleukin-6, could explain this newly observed phenomenon of the immunoglobulin E response to the tissue injury. Behaviour of serum IgE, as described by us, bears much resemblance to that of acute phase proteins. In conclusion, we hypothesize that immunoglobulin E may act in human organism as an acute phase protein.
Pol Arch Med Wewn 1995 Dec
PMID:[Humoral immune response to tissue injury, characterized by a rise in serum immunoglobulin E]. 861 12

Serum concentration of three positive acute phase proteins: C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP), alpha-1-antychymotrypsin (ACT) were measured in 81 patients with endogenous depression during acute episode and in 20 matched controls. Determination was also made of glycosylation types of AGP and ACT as well as of the concentration of interleukin-6 (IL-6) and its soluble receptor (sIL-6R). In patients with depression, the mean values of all parameters studied except for AGP glycosylation were significantly elevated compared with the group of control healthy persons, what may suggest an excessive immune activation in these patients in the form of acute phase response. Particularly intense were the indies of the immune activation in the subgroup of patients (1/3 of population studied) having pathologically elevated coefficient of AGP glycosylation (Type I glycosylation). Patients with Type I glycosylation had longer duration of illness and were characterized by recent depressive episode of greater severity and chronicity as well as refractoriness to pharmacological treatment. The results obtained corroborate the existence of excessive immune activation during acute depressive episode and suggest the possible role of this phenomenon in the pathogenesis and course of affective illnesses.
Psychiatr Pol
PMID:[Immune activation in endogenous depression]. 898 17

Serum and urinary tumor necrosis factor-alpha (SeTNF and UTNF) and interleukin-6 (SeIL-6 and UIL-6) by ELISA method were determined in 99 patients with glomerulonephritis (GN): 13 with extracapillaris GN (ExGN), 38 with membranoproliferative GN (MPGN), 33 mesangial proliferative GN (MesPGN), 5 with focal segmental glomerulosclerosis (FSGS), 5 with membranous nephropathy (MN), 3 with minimal change nephropathy (MC) and in 32 healthy adults. The higher levels of Se TNF than those in the healthy were in 25 patients: in nearly all with ExGN, in 8 with MPGN and in single patients with other GN. In all patients with high SeTNF were many extra renal organs involvement. Measurable levels of UTNF were in 30 patients (30%) (in 12 with ExGN, 9 with MPGN, 7 with MesPGN, 1 with MN, and 1 with FSGS). Most patients with high SeTNF belonged to group I. The higher levels of SeIL-6 than those in healthy were in 17 patients belonging to group I, in which high SeIL-6 were in 3 patients with ExGN, 6 with MPGN, 3 with MesPGN, 2 with MN, and 3 with FSGS. Measurable urinary IL-6 levels were in 27 (27%) patients, mainly in group I, and in single patients in other groups. The majority of patients with ExGN and MPGN from group I and UIL-6 positive suffered from renal insufficiency and histologically had proliferative GN. We conclude that the elevation of TNF alpha and/or IL-6 in plasma may reflect a secondary consequence of immune cells activation while urinary TNF alpha and/or IL-6 may be secreted by activated glomerular cells. Thus, high levels of TNF alpha and/or IL-6 in serum of patients with GN and extra renal organs involvement, peculiary with infections, suggested antibiotics therapy, because infection may stimulated cytokines production and they are important in pathogenesis and progress of GN. High urinary levels of IL-6 and (or) TNF alpha in patients with proliferative GN suggest great disease activity and is useful in the evaluating of IS treatment.
Pol Arch Med Wewn 1996 Sep
PMID:[Tumor necrosis factor (TNF) and interleukin-6 (IL-6) in patients with glomerulonephritis]. 912 13

The aim of this study was evaluation of interleukin-6 (IL-6) and interleukin-8 (IL-8) in creation of inflammation of lower airways in patients with chronic bronchitis. 32 patients with chronic bronchitis and 14 subjects of control group took part in this study. Spirometry (Jaeger eq.), bronchofibroscopy and bronchoalveolar lavage (Olympus eq.) were performed in every patient. Cytology and concentration of IL-6 and IL-8 (kits from R&D) were measured in 1 ml of lavage fluid recovered. The increased levels of IL-6 and IL-8 in BAL were correlated with clinical parameters. We conclude that these two cytokines participate in creation of inflammatory changes of lower respiratory tract in chronic bronchitis.
Pol Merkur Lekarski 1996 Dec
PMID:[Interleukin-6 and interleukin-8 in bronchoalveolar lavage fluid material from patients with chronic bronchitis]. 927 26

7 out of 154 patients with multiple myeloma (MM) with concomitant rheumatoid arthritis (RA) (5 persons) and Bechterev disease (BD) (2 persons) have been presented. There were 5 women and 2 men at age from 52 to 67 years. Four of them had joint's disease for 4, 5, 24 and 25 years prior to MM, and in the next there MM was diagnosed simultaneously with RA. Two patients are still living (50 and 55 months from the diagnosis of MM), the mean survival time of the five already dead was 34.5 months, and did not differ from the survival of patients with MM alone. The contribution of interleukin-6 (Il-6) and adhesion molecules ICAM-1, VCAM-1, CD44 in pathogenesis of both diseases are discussed.
Pol Arch Med Wewn 1997 Mar
PMID:[Rheumatoid arthritis as a risk factor for development of multiple myeloma]. 933 71

Heart failure is a common and increasing public problem. Neurohormonal activation plays a role in the pathophysiology of heart failure, but is probably also affected by cytokines. We studied 75 patients with heart failure NYHA functional class II and III-IV, who were treated with angiotensin converting enzyme inhibitor (enarenal), diuretics (furosemide) and digoxine. Their mean age was 63.9 years/range 65-86/, left ventricular ejection fraction in the patients NYHA functional class II and III-IV classes was 68.9% and 47.3% respectively; 12 were females. Significant improvements in NYHA classification were shown. The levels plasma TNF-alpha (tumor necrosis factor-alpha) and interleukin-6 (IL-6) were analysed before and after therapy. The authors showed increased plasma levels TNF-alpha and IL-6 in patients with chronic heart failure. After the treatment the plasma IL-6 levels decreased only in the patients III-IV NYHA functional classes, whereas the treatment had no effect on the plasma TNF-alpha levels.
Pol Merkur Lekarski 1999 Aug
PMID:[Do cytokines have any value in the patients with chronic blood circulation insufficiency?]. 1052 13

In the present study, some new amides of 5-amino-3-methylisoxazole-4-carboxylic acid were obtained. All new structures possessed markedly different groups of electron acceptor character, different spatial structure and they contained nitrogen heteroatom, enabling formation of salts and, at the same time, higher biological availability. They were examined for immunomodulating activity in comparison with cyclosporine A (CsA). We investigated effects of the compounds on the lipopolysaccharide (LPS)-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by human peripheral blood cells. Some compounds exhibited suppressory action which corresponded with increasing electronoacceptor nature of the amide substituent. Two compounds, characterized by flat aromatic rings, demonstrated quite different properties. Much higher activity was expressed by compounds which contained -NH group, the group which conditioned immunostimulatory activity in other compounds described previously.
Pol J Pharmacol
PMID:Immunological activity of new heterocyclic amides of 5-amino-3-methylisoxazole-4-carboxylic acid. 1060 40


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