Gene/Protein
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Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UNIPROT:P05231 (
interleukin-6
)
23,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-6
(
IL-6
)-induced glycolysis and therapeutic resistance is reported in some cell systems; however, the mechanism of
IL-6
-induced glycolysis in radio-resistance is unexplored. Therefore, to investigate, we treated Raw264.7 cells with
IL-6
(1 h prior to irradiation) and examined the glycolytic flux. Increased expression of mRNA and protein levels of key glycolytic enzymes was observed after
IL-6
treatment, which conferred glycolysis dependent resistance from radiation-induced cell death. We further established that
IL-6
-induced glycolysis is activated by Akt signalling and knocking down Akt or inhibition of pan Akt phosphorylation significantly abrogated the
IL-6
-induced radio-resistance. Moreover, reduction of
IL-6
-induced pAkt level suppressed the expression of
Hexokinase-2
and its translocation to the mitochondria, thereby inhibiting the glycolysis-induced resistance to radiation.
IL-6
-induced glycolysis also minimized the radiation-induced mitochondrial damage. These results suggest that
IL-6
-induced glycolysis observed in cells may be responsible for
IL-6
-mediated therapeutic radio-resistance in cancer cells, partly by activation of Akt signalling.
...
PMID:Interleukin-6 confers radio-resistance by inducing Akt-mediated glycolysis and reducing mitochondrial damage in cells. 3167 Aug 6
