Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05231 (
interleukin-6
)
23,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In the previous study, we demonstrated that the nuclear isoform of
T-cell protein-tyrosine phosphatase
(
TC-PTP
) dephosphorylated and deactivated signal transducer and activator of transcription 5a (STAT5a) and STAT5b, thereby negatively regulating prolactin (PRL)-mediated signaling pathway. In this study, we examined the involvement of the nuclear isoform of
TC-PTP
in
interleukin-6
(
IL-6
)-mediated signaling pathway.
IL-6
is a multifunctional cytokine that plays important roles in the immune system, hematopoiesis, and acute phase reactions, and has also implicated in
IL-6
-related diseases. Here, we demonstrate that
IL-6
-induced tyrosine-phosphorylation and activation of STAT3 were suppressed by overexpression of the nuclear isoform of
TC-PTP
in 293T cells. Tyrosine-phosphorylated STAT3 directly interacted with a substrate-trapping mutant of
TC-PTP
. Furthermore, retrovirus-mediated overexpression of the nuclear isoform of
TC-PTP
suppressed the
IL-6
-induced growth arrest of myeloid leukemia M1 cells. Endogenous
TC-PTP
complexed with STAT3 in the nucleus of M1 cells. These results strongly suggest that the nuclear isoform of
TC-PTP
may serve as a negative regulator of
IL-6
-mediated signaling pathway.
...
PMID:The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. 1235 25
