Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05231 (
interleukin-6
)
23,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Radiotherapy is a crucial approach for treating tumors. However, radiation-induced aseptic inflammation is a common complication. Radiation pneumonitis is the acute manifestation of radiation-induced lung disease, and interleukin 6 (IL-6) is a major proinflammatory cytokine involved in radiation-induced lung injury. Here we found that silencing
Zinc finger and BTB domain-containing protein 7B
(Zbtb7b) resulted in higher radiation-induced IL-6 production in THP1 cells and BEAS-2B lung bronchial epithelial cells. Mechanistically, Zbtb7b recruited RNA demethylase ALKBH5 to
IL6 mRNA
. Subsequentially, it demethylated N
6
-methyladenosine (m
6
A) modification of
IL6 mRNA
and inhibited its nuclear export. Thus, Zbtb2b epigenetically suppresses irradiation-induced IL-6 production in the lungs via inhibiting the m
6
A modification and nucleocytoplasmic transport of
IL6 mRNA
, serving as a new potential predictive marker and therapeutic target in radiation pneumonitis treatment.
...
PMID:Zbtb7b suppresses aseptic inflammation by regulating m
6
A modification of IL6 mRNA. 3282 8
