Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05231 (
interleukin-6
)
23,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The interaction of cells within the glomerulus plays an important role in the development and progression of glomerular disease. To investigate the interaction of glomerular mesangial cells (GMC) and epithelial cells (GEC), and mediator(s) of this interaction, we investigated the effect of Adriamycin (doxorubicin hydrochloride)-induced (
ADR
) rat GMC-conditioned medium (GMC-CM) on the incorporation of 35S, 3H-leucine, and 3H-thymidine in normal rat GEC, as well as 3H-thymidine uptake by normal rat GMC in response to
ADR
-rat GEC-CM. In addition, changes in the responsiveness to
interleukin-6
(
IL-6
) and the products of
IL-6
were assessed in
ADR
-rat GMC. The results showed that: (1) GMC-CM of
ADR
-rat with heavy proteinuria stimulated GEC proliferation and the synthesis of sulfated compounds and protein, while the GEC-CM of
ADR
-rat from the same nephrotic period increased GMC proliferation; (2) the
ADR
-rat GMC had altered responsiveness to
IL-6
and its products. The stimulation index results demonstrated the interaction of GMC and GEC in the
ADR
-induced rat model, and that this interaction related closely to the degree of proteinuria and was mediated by soluble products of the damaged glomerular cell.
...
PMID:The interaction of glomerular mesangial cells and epithelial cells. 963 36
