Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05231 (
interleukin-6
)
23,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this study, we proposed to modify mesoporous silica nanoparticles (MSNs) with 3-aminopropyltriethoxysilane (NH
2
-
TES
), aminoethylaminopropyltriethoxysilane (2NH
2
-
TES
) and 3-[2-(2-aminoethylamino)ethylamino] propyl-trimethoxysilane (3NH
2
-
TES
) for binding of cytosine-phosphate-guanosine oligodexynucleotides (CpG ODN), and investigated the effect of different amino groups of MSNs on the CpG ODN delivery. Serum stability,
in vitro
cytotoxicity, and cytokine
interleukin-6
(
IL-6
) induction by MSN-NH
2
/CpG, MSN-2NH
2
/CpG and MSN-3NH
2
/CpG complexes were investigated in detail. The results showed that three kinds of aminated-MSN-based CpG ODN delivery systems had no cytotoxicity to RAW264.7 cells, and binding of CpG ODN to MSN-NH
2
, MSN-2NH
2
and MSN-3NH
2
nanoparticles enhanced the serum stability of CpG ODN due to protection by the nanoparticles. However, three aminated MSN-based CpG ODN delivery systems exhibited different CpG ODN delivery efficiency, and MSN-NH
2
/CpG complexes had the highest ability to induce
IL-6
secretion.
...
PMID:Effect of amino groups of mesoporous silica nanoparticles on CpG oligodexynucleotide delivery. 2787 26
