Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05231 (
interleukin-6
)
23,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We experienced a 47-year-old Japanese female with polyneuropathy, edema, hypertrichosis, hyperpigmentation, and white nail, which were diagnostic as having Crow-Fukase syndrome. Laboratory and radiological evaluation showed neither plasma cell dyscrasia nor monoclonal gammopathy. Increased factor VIII activity and thrombocytosis, which suggested thrombotic tendency, were observed at the exacerbation of clinical symptoms. In her third exacerbation, she presented marked
cyanosis
in her right foot, and angiography confirmed narrowing of arteries at the ankle. Increased serum
interleukin-6
was also observed, and the production of
interleukin-6
by endothelial cells of cutaneous angioma was shown. Possible role of
interleukin-6
in Crow-Fukase syndrome was discussed.
...
PMID:[A case of Crow-Fukase syndrome with increased serum interleukin-6]. 178 57
