Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05231 (
interleukin-6
)
23,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Propagation of the undifferentiated pluripotential phenotype of embryonic stem (ES) cells is dependent on the cytokine differentiation inhibiting activity/leukemia inhibitory factor (
DIA
/LIF). The
DIA
/LIF receptor complex is a heterodimer of
DIA
/LIF receptor (
DIA
/LIF-R) and gp130. The latter is also a component of the
interleukin-6
(
IL-6
) receptor complex. We report that a combination of
IL-6
and soluble
IL-6
receptor (sIL-6R), which can induce homodimerisation of gp130 and activation of signalling processes, sustains self-renewal of pluripotential ES cells. Our findings indicate that the
IL-6
/sIL-6R complex acts on ES cells through gp130 alone, bypassing
DIA
/LIF-R, and therefore implicate gp130 as the key component in the signalling pathway responsible for stem cell renewal.
...
PMID:Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways. 819 53
