Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P05231 (interleukin-6)
 23,907 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Undifferentiated thymic carcinoma is a rare tumor of the thymus. Due to the extreme rarity of undifferentiated thymic carcinoma, very limited information about its characteristics is available. We encountered an autopsy case of a 33-year-old woman diagnosed as having an undifferentiated thymic carcinoma with a high inflammatory response. The patient's serum interleukin-6 (IL-6) was elevated to 1930 pg/ml, and immunohistochemical staining of the carcinoma cells was positive for neuroendocrine markers and IL-6. To the best of our knowledge, this is the first report of an IL-6-producing undifferentiated thymic carcinoma with neuroendocrine features that shows a novel potential to produce IL-6.
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PMID:Interleukin-6-producing undifferentiated thymic carcinoma with neuroendocrine features. 1880 10

Granulocyte colony-stimulating factor (G-CSF)-producing thymic carcinoma is extremely rare. A-66-year-old man presented with an anterior mediastinal mass, and underwent surgical biopsy. He had marked leukocytosis, and his serum levels of G-CSF and interleukin-6 were elevated. Histologically, the tumor consisted of squamous cell carcinoma, which showed positive immunoreactivity for G-CSF. He was treated with thoracic radiotherapy, and chest imaging revealed a marked reduction of tumor size. He was doing well at 8 months after tumor diagnosis.
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PMID:Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6. 1996 91