Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05231 (
interleukin-6
)
23,907
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-6
(
IL-6
) is a multifunctional cytokine that participates in the inflammatory and immune responses. In human skin, keratinocytes produces
IL-6
, although the in vivo role of this cytokine is unknown. In the present study we investigated the in situ localization of
IL-6
in normal epidermis (n = 10) and in a group of skin diseases characterized by epidermal atrophy. Formalin-fixed paraffin-embedded skin biopsies from patients with clinical and histopathological features consistent with localized scleroderma (n = 10), systemic scleroderma (n = 5), lichen sclerosus et atrophicus (n = 9) and
balanitis
xerotica obliterans (n = 7) were tested using polyclonal antibodies and avidin-biotin-peroxidase immunostaining. We demonstrated the presence of
IL-6
in normal epidermis and in atrophic skin diseases. In normal skin there was moderate intercellular and intracellular reactivity detected using a high antibody concentration. In specimens with epidermal atrophy we detected intense cytoplasmic and intercellular immunostaining using a lower antibody concentration. The immunoreactivity was independent of the epidermal thickness. Plasma
IL-6
, measured by radioimmunoassay, was not elevated in plasma from patients with localized or systemic scleroderma. Increased
IL-6
in the epidermis of selected skin diseases suggests that
IL-6
may be related to the pathophysiology of dermatologic diseases characterized by epidermal atrophy.
...
PMID:In situ localization of interleukin-6 in normal skin and atrophic cutaneous disease. 134 91
