Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P05109 (S100A8)
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Human Gene/Protein
zinc finger protein 83 14.7
S100A8 14.7
DDX21 protein 14.7
Heat shock 70kDa protein 1B 14.7
S100A9 13.9
keratin 25 13.7
S100A7L2 13.7
Glutathione S-transferase theta 1 13.7
AZGP1 protein 13.7
S100A12 13.1
PRR4 13.1
cystic fibrosis antigen 13.1
S100Z 13.1
CD81 antigen 13.1
PDA2 13.1
EPH receptor B2 13.1
ectonucleotide pyrophosphatase/phosphodiesterase 5 13.1
ZNF84 13.1
late cornified envelope-like proline-rich 1 13.1
HSH2D 13.1
F-actin capping protein alpha-1 subunit 13.1
U6 snRNA-associated Sm-like protein LSm3 13.1
Acidic leucine-rich nuclear phosphoprotein 32 family member B 13.1
SUSD5 13.1
CAAF1 12.9
prefoldin subunit 5 12.7
IP3K-B 12.4
zymogen granule protein 16 homolog B 12.4
S100A5 12.4
APOLD1 12.4
FAM46B 12.4
Flamingo1 12.4
SPRR2D 12.4
SNRPG 12.4
CPXM2 12.4
MRP8 12.3
S100A3 12.2
NIF 12.2
SOSTDC1 12.2
LSM3 12.1
F-actin-capping protein subunit alpha-1 11.9
wingless-type MMTV integration site family, member 5A 11.9
Grancalcin 11.9
PLEKHB1 11.9
ADCY4 11.9
PPP1R3D 11.9
RASAL3 11.9
EIF4F 11.9
POLR1B 11.9
interferon gamma receptor 2 11.9
S100A15 11.8
KRT4 11.8
S100A7 11.8
S100A11 11.7
SPRR4 11.7
tubulin, beta 11.7
SPRR2B 11.7
SPRR1 11.7
MRP14 11.6
REG1B 11.5
KLRF1 11.5
leukolysin 11.5
ENDOD1 11.5
BPLP 11.5
S100A2 11.5
C1QB 11.5
neuroplastin 11.4
RAD23A 11.4
NIF-1 11.4
GBP6 11.4
keratinocyte proline-rich protein 11.4
ACBD5 11.4
advanced glycosylation end product-specific receptor 11.4
NME5 11.4
S100A13 11.2
LC8a 11.2
SPRR2A 11.2
SMD2 11.2
Basalin 11.2
ERP29 11.2
more...
Disease
Jessner's lymphocytic infiltration 10.9
Funisitis 10.9
Systemic juvenile idiopathic arthritis 10.5
bladder cancer stage 10.4
Cystic endometrial hyperplasia 10.0
Vulvovaginal candidiasis 9.9
Chronic endometritis 9.8
Bacterial keratitis 9.6
peritonsillitis 9.4
facet joint degeneration 9.3
Hepatic cysts 9.0
CACA 8.7
Laminitis 8.6
Primary cutaneous amyloidosis 8.4
Lentigo maligna 7.9
Keratoacanthoma 7.8
Spondyloarthritis 7.6
FRA 7.4
chronic eosinophilic leukemia 7.3
Bianchi 7.2
Neonatal sepsis 7.0
vaginal infection 6.9
BOS 6.9
Spitz nevus 6.8
CAE 6.7
CAE 6.7
Cat scratch disease 6.7
placentitis 6.6
vaginal candidiasis 6.6
BLS 6.6
Adult-onset Still's disease 6.6
oropharyngeal squamous cell carcinoma 6.5
xanthomatosis 6.5
Mastocytosis 6.4
Chimera 6.4
pyometra 6.4
hypertensive nephropathy 6.4
Cerebral malaria 6.2
HNSCC 6.2
monocytic leukemia 6.1
anterior uveitis 6.1
Still's disease 6.1
acute tonsillitis 6.1
peritonsillar abscess 6.0
laryngeal squamous cell carcinoma 6.0
plexiform neurofibroma 6.0
dermatofibroma 6.0
DHS 5.9
MAR 5.9
DHS 5.9
dry eye syndrome 5.8
Frontotemporal dementia 5.8
Ross River 5.8
tophi 5.8
psoriasis 5.8
Fibrodysplasia ossificans progressiva 5.8
epidermodysplasia verruciformis 5.8
pediatric AML 5.7
metastatic colon cancer 5.7
PCD 5.7
immune disorder 5.6
Roth 5.6
dental calculus 5.6
Peripheral arterial disease 5.6
colibacillosis 5.6
Zinc deficiency 5.5
Johne's disease 5.5
monkeypox 5.5
SIRS 5.5
PPR 5.5
endometritis 5.5
intestinal cancer 5.4
fetal infection 5.4
uvea 5.4
transitional cell carcinoma 5.3
LCA 5.3
LIN 5.3
skin disease 5.2
infectious endocarditis 5.2
MIP 5.2
more...
Symptom
scaly skin 7.3
Scratch 6.1
Gastrointestinal symptoms 5.5
halitosis 5.5
Fluctuation 5.4
dry eye 5.3
muscle cramps 4.9
microbial colonization 4.6
skin damage 4.1
fever of unknown origin 3.7
erythema 3.0
wheezing 2.5
hepatomegaly 2.2
starvation 2.1
back pain 1.1
functional recovery 1.0
exhaustion 0.9
chest pain 0.6
hypothermia 0.6
diarrhea 0.5
respiratory distress 0.4
discomfort 0.2
discomfort 0.1
abdominal pain -0.2
pain -0.5
weakness -0.5
Drug
Ferumoxytol 8.1
NOV 6.9
Imiquimod 6.6
Fulvestrant 6.2
Tocilizumab 6.0
Activin 5.5
Rutin 5.3
PDL 5.3
Camp 5.2
G-CSF 5.1
GEO 5.1
CIA 5.1
Methylprednisolone 4.8
CTC 4.6
Doxycycline 4.6
Retinoic acid 4.5
CTC 4.3
Pronase 4.3
IL-1ra 4.3
Prednisolone 4.1
Allergen 4.1
ROC 4.1
MRC 3.9
p75 3.8
-deoxyadenosine 3.7
uPA 3.6
Forskolin 3.3
Glutathione 3.3
IFN-beta 3.1
ADM 3.1
Taxol 3.0
ROS 3.0
CSF 2.9
Gel 2.8
Glucagon 2.8
IFN-gamma 2.7
Adriamycin 2.5
Albumin 2.4
Angiotensin II 2.4
MAP 2.3
CTX 2.2
CTX 2.2
PTH 1.9
IL-2 1.8
Dermatol 1.6
Monit 1.6
ABC 1.6
CTX 1.4
TiO2 1.2
Asthma 1.0
NADH 0.3
lysine -0.2
Cardiovasc -1.9
Enzyme
retinal dehydrogenase 8.6
methylenetetrahydrofolate dehydrogenase 7.9
SNO 7.7
phosphoserine phosphatase 7.6
methylenetetrahydrofolate dehydrogenase 7.5
proteinase-3 7.3
dihydropteroate synthase 7.2
KLK7 7.2
kynureninase 7.1
neutrophil collagenase 7.1
amylomaltase 7.0
S-adenosyl-L-homocysteine hydrolase 6.6
LTA4 hydrolase 6.4
Omi/HtrA2 6.3
FPS 6.2
caspase-4 6.2
nicotinamide phosphoribosyltransferase 6.1
TMT 6.1
TACE 6.0
transaldolase 6.0
caspase-4 6.0
cyclohydrolase 5.9
lysyl oxidase 5.4
factor C 5.4
heparinase 5.4
dihydrofolate reductase 5.3
MIP 5.2
indoleamine 2,3-dioxygenase 5.2
arginase 5.1
SST 5.1
AGT 5.1
matrix metalloproteinase 2 5.1
ubiquitin-protein ligase 5.0
MMP-3 4.9
NADPH oxidase 4.9
12-lipoxygenase 4.9
PHD 4.9
SPT 4.9
NADPH oxidase 4.8
interstitial collagenase 4.8
histone demethylase 4.8
cathepsin L 4.7
BAL 4.7
ALA synthase 4.7
neuropathy target esterase 4.6
luciferase 4.5
peroxiredoxin 4.3
neutrophil elastase 4.3
LPL 4.3
cathepsin D 4.3
PGM 4.2
acyl-CoA dehydrogenase 4.2
chitinase 4.2
polo-like kinase 1 4.1
caspase-1 4.1
furin 4.0
alpha-amylase 3.9
tryptophan hydroxylase 3.9
cathepsin G 3.9
collagenase 3.8
prostaglandin synthetase 3.8
cathepsin K 3.8
proteinase K 3.7
chondroitinase 3.7
mitogen-activated protein kinase 3.7
cathepsin B 3.7
MMP 3.6
chondroitinase 3.6
matrix metalloproteinase 9 3.6
peroxidase 3.5
ATP synthase 3.5
NOS 3.4
transglutaminase 3.4
MAP 3.4
ceruloplasmin 3.4
chloramphenicol acetyltransferase 3.4
ERK 3.3
trypsin 3.3
lysozyme 3.3
MDP 3.3
more...
Compound
PPBP 10.1
Narciclasine 10.1
2-hydroxy-3-methoxybenzaldehyde 9.4
5,5-dimethyl-1,3-cyclohexanedione 8.7
Flucloxacillin 8.7
Trenimon 8.6
Tazarotene 7.9
P-D 7.8
3,4-dihydroxybenzaldehyde 7.8
Fibrinopeptide A 7.6
3,4-dihydroxybenzaldehyde 7.4
TTNPB 7.4
DTE 7.1
TIF 6.8
SSH 6.6
Cordycepin 6.4
Cordycepin 6.4
Cordycepin 6.4
IDC 6.4
Pyrimethamine 6.4
Thymine 6.2
DEK 6.1
TACE 6.0
DAMP 6.0
Poly(I:C) 5.9
Dibutyryl cyclic AMP 5.9
Tumor Necrosis Factor 5.9
Dibutyryl cyclic AMP 5.9
Keratin 5.7
Daunorubicin 5.7
AGE 5.7
Leukotriene B4 5.7
Coenzyme A 5.6
PGFM 5.6
FMLP 5.5
Carrageenan 5.5
5-Aza-2'-deoxycytidine 5.5
Heparan sulfate 5.4
Flavonoid 5.4
Phorbol 12-myristate 13-acetate 5.3
Brilliant Blue 5.2
Lip 5.2
TTA 5.2
DAMP 5.2
SO3 5.2
Sulforaphane 5.1
Plasmin 5.1
IPA 5.0
IPA 5.0
IPA 5.0
4-hydroxybenzoic acid 5.0
Methylprednisolone 5.0
IPA 5.0
BAP 5.0
Brefeldin A 5.0
CHIP 5.0
Brefeldin A 5.0
Evans Blue 4.9
Rutin 4.8
THP 4.8
TNF 4.8
THP 4.8
PMA 4.7
Diclofenac 4.6
Doxycycline 4.6
DAG 4.5
Oil Red O 4.5
XTT 4.4
keratan sulfate 4.4
NTA 4.4
MES 4.3
MES 4.3
TOF 4.3
PMA 4.3
BAL 4.3
Oleic acid 4.2
LIN 4.2
ClO 4.2
Prednisolone 4.2
Oil Red O 4.1
more...