Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P05109 (S100A8)
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Human Gene/Protein
Heat shock 70kDa protein 1B 14.7
S100A8 14.7
DDX21 protein 14.7
zinc finger protein 83 14.7
S100A9 13.9
S100A7L2 13.7
Glutathione S-transferase theta 1 13.7
keratin 25 13.7
AZGP1 protein 13.7
S100A12 13.1
PDA2 13.1
PRR4 13.1
HSH2D 13.1
SUSD5 13.1
Acidic leucine-rich nuclear phosphoprotein 32 family member B 13.1
U6 snRNA-associated Sm-like protein LSm3 13.1
CD81 antigen 13.1
ectonucleotide pyrophosphatase/phosphodiesterase 5 13.1
ZNF84 13.1
F-actin capping protein alpha-1 subunit 13.1
cystic fibrosis antigen 13.1
EPH receptor B2 13.1
S100Z 13.1
late cornified envelope-like proline-rich 1 13.1
CAAF1 12.9
prefoldin subunit 5 12.7
Flamingo1 12.4
APOLD1 12.4
FAM46B 12.4
S100A5 12.4
zymogen granule protein 16 homolog B 12.4
IP3K-B 12.4
SNRPG 12.4
CPXM2 12.4
SPRR2D 12.4
MRP8 12.3
S100A3 12.2
NIF 12.2
SOSTDC1 12.2
LSM3 12.1
PPP1R3D 11.9
PLEKHB1 11.9
wingless-type MMTV integration site family, member 5A 11.9
EIF4F 11.9
F-actin-capping protein subunit alpha-1 11.9
interferon gamma receptor 2 11.9
ADCY4 11.9
RASAL3 11.9
POLR1B 11.9
Grancalcin 11.9
KRT4 11.8
S100A15 11.8
S100A7 11.8
S100A11 11.7
tubulin, beta 11.7
SPRR4 11.7
SPRR1 11.7
SPRR2B 11.7
MRP14 11.6
ENDOD1 11.5
REG1B 11.5
leukolysin 11.5
BPLP 11.5
KLRF1 11.5
S100A2 11.5
C1QB 11.5
neuroplastin 11.4
NME5 11.4
RAD23A 11.4
NIF-1 11.4
ACBD5 11.4
GBP6 11.4
advanced glycosylation end product-specific receptor 11.4
keratinocyte proline-rich protein 11.4
S100A13 11.2
Basalin 11.2
LC8a 11.2
SPRR2A 11.2
ERP29 11.2
SMD2 11.2
IL-1F9 11.2
SPRR3 11.1
calgranulin C 11.1
ribonuclease 7 11.1
HBP2 11.1
BCL2L15 11.1
ITIH2 11.1
prenylcysteine lyase 11.1
NEUROD6 11.0
PFDN5 11.0
SCEL 11.0
FCGR2 10.9
FOXD4 10.9
TRAP150 10.9
CST4 10.9
MS4A3 10.9
RPS3A 10.9
galectin 3 binding protein 10.9
AOAH 10.9
HLAG 10.9
IL18RAP 10.8
S100A1 10.8
repetin 10.8
STK31 10.8
DEFA1 10.7
S100A10 10.7
S100A6 10.7
SPRR1B 10.7
SNCAIP 10.7
HSPCA 10.7
NDUFA5 10.7
KRT13 10.6
PBII 10.6
Cartilage acidic protein 1 10.6
C1QC 10.5
SCUBE2 10.5
endofin 10.5
CORO1A 10.5
COL5A3 10.5
ANXA13 10.5
TRIM65 10.5
IFI30 10.5
SERPINB4 10.5
neutrophil protein 10.5
receptor for advanced glycation end-products 10.5
FOXL2 protein 10.4
DEFA4 10.4
PAPPA2 10.4
TUBA8 10.4
SAA3 10.4
GNG11 10.4
PSMA2 10.4
EPSTI1 10.4
MGLL 10.4
PIGR 10.4
TXNDC5 10.4
CILP2 10.4
histone H1.3 10.4
ATP5C1 10.4
SEPT1 10.3
LGALS8 10.3
CRISPLD2 10.3
FLOT1 10.3
AKNA 10.3
IL1R 10.2
LTF 10.2
PCTAIRE 10.2
Naf1 10.2
CORA 10.2
PYGB 10.2
calcyphosine 10.2
REG1A 10.2
DEFB4 10.2
LCN2 10.1
MMP8 10.1
interleukin-11 receptor 10.1
SORBS1 10.1
PDIA4 10.1
S100A14 10.1
HIN-1 10.1
more...
Disease
Jessner's lymphocytic infiltration 10.9
Funisitis 10.9
Systemic juvenile idiopathic arthritis 10.5
bladder cancer stage 10.4
Cystic endometrial hyperplasia 10.0
Vulvovaginal candidiasis 9.9
Chronic endometritis 9.8
Bacterial keratitis 9.6
peritonsillitis 9.4
facet joint degeneration 9.3
Hepatic cysts 9.0
CACA 8.7
Laminitis 8.6
Primary cutaneous amyloidosis 8.4
Lentigo maligna 7.9
Keratoacanthoma 7.8
Spondyloarthritis 7.6
FRA 7.4
chronic eosinophilic leukemia 7.3
Bianchi 7.2
Neonatal sepsis 7.0
vaginal infection 6.9
BOS 6.9
Spitz nevus 6.8
CAE 6.7
CAE 6.7
Cat scratch disease 6.7
placentitis 6.6
vaginal candidiasis 6.6
BLS 6.6
Adult-onset Still's disease 6.6
oropharyngeal squamous cell carcinoma 6.5
xanthomatosis 6.5
Mastocytosis 6.4
Chimera 6.4
pyometra 6.4
hypertensive nephropathy 6.4
Cerebral malaria 6.2
HNSCC 6.2
monocytic leukemia 6.1
anterior uveitis 6.1
Still's disease 6.1
acute tonsillitis 6.1
peritonsillar abscess 6.0
laryngeal squamous cell carcinoma 6.0
plexiform neurofibroma 6.0
dermatofibroma 6.0
DHS 5.9
MAR 5.9
DHS 5.9
dry eye syndrome 5.8
Frontotemporal dementia 5.8
Ross River 5.8
tophi 5.8
psoriasis 5.8
Fibrodysplasia ossificans progressiva 5.8
epidermodysplasia verruciformis 5.8
pediatric AML 5.7
metastatic colon cancer 5.7
PCD 5.7
immune disorder 5.6
Roth 5.6
dental calculus 5.6
Peripheral arterial disease 5.6
colibacillosis 5.6
Zinc deficiency 5.5
Johne's disease 5.5
monkeypox 5.5
SIRS 5.5
PPR 5.5
endometritis 5.5
intestinal cancer 5.4
fetal infection 5.4
uvea 5.4
transitional cell carcinoma 5.3
LCA 5.3
LIN 5.3
skin disease 5.2
infectious endocarditis 5.2
MIP 5.2
keratoacanthoma 5.2
dermatitis 5.2
enthesitis 5.2
vaginitis 5.2
microcytic anemia 5.2
Plasmodium falciparum infection 5.1
anal cancer 5.1
synovitis 5.1
multiple disorders 5.1
immunopathology 5.0
anal cancer 5.0
galactosemia 5.0
Lymph nodes 5.0
Kawasaki disease 5.0
ovarian cysts 5.0
chronic cholecystitis 5.0
parakeratosis 4.9
chorioamnionitis 4.9
keratitis 4.9
HGF 4.9
Lip 4.9
histiocytic lymphoma 4.9
metritis 4.9
Malignant transformation 4.9
STEMI 4.9
MEC 4.9
familial Mediterranean fever 4.8
skin tumor 4.8
atopic dermatitis 4.8
maple syrup urine disease 4.8
ichthyosis 4.8
urolithiasis 4.7
transitional cell carcinoma of the bladder 4.7
Testes 4.7
FAS 4.7
myeloproliferative disorders 4.7
primary myelofibrosis 4.6
protein deficiency 4.6
hyperkeratosis 4.6
ICT 4.6
cervical squamous cell carcinoma 4.6
mastocytosis 4.6
diabetic foot ulcers 4.6
Thrombus 4.6
ichthyosis 4.6
HELLP syndrome 4.6
spondyloarthropathy 4.6
upper respiratory infection 4.5
trismus 4.5
bronchopneumonia 4.5
HLA-B27 4.5
osteoarthritis of the knee 4.5
EL4 4.5
LAP 4.5
gingivitis 4.5
bovine leukemia 4.4
juvenile rheumatoid arthritis 4.4
polymyalgia rheumatica 4.4
essential thrombocythemia 4.4
ductal carcinoma 4.4
periodontitis 4.4
COPD 4.4
Beckwith-Wiedemann syndrome 4.4
colitis 4.3
gout 4.3
MAC 4.3
Diffuse large B-cell lymphoma 4.3
glycogen storage disease 4.3
leukoplakia 4.3
Esophageal squamous cell carcinoma 4.3
spondylitis 4.3
leg ulcers 4.2
abdominal obesity 4.2
endotoxic shock 4.2
histiocytic lymphoma 4.2
uveitis 4.2
premature rupture of membranes 4.1
Robin 4.1
lupus nephritis 4.1
skin cancer 4.1
more...
Symptom
scaly skin 7.3
Scratch 6.1
Gastrointestinal symptoms 5.5
halitosis 5.5
Fluctuation 5.4
dry eye 5.3
muscle cramps 4.9
microbial colonization 4.6
skin damage 4.1
fever of unknown origin 3.7
erythema 3.0
wheezing 2.5
hepatomegaly 2.2
starvation 2.1
back pain 1.1
functional recovery 1.0
exhaustion 0.9
chest pain 0.6
hypothermia 0.6
diarrhea 0.5
respiratory distress 0.4
discomfort 0.2
discomfort 0.1
abdominal pain -0.2
pain -0.5
weakness -0.5
Drug
Ferumoxytol 8.1
NOV 6.9
Imiquimod 6.6
Fulvestrant 6.2
Tocilizumab 6.0
Activin 5.5
Rutin 5.3
PDL 5.3
Camp 5.2
G-CSF 5.1
GEO 5.1
CIA 5.1
Methylprednisolone 4.8
CTC 4.6
Doxycycline 4.6
Retinoic acid 4.5
CTC 4.3
Pronase 4.3
IL-1ra 4.3
Prednisolone 4.1
Allergen 4.1
ROC 4.1
MRC 3.9
p75 3.8
-deoxyadenosine 3.7
uPA 3.6
Forskolin 3.3
Glutathione 3.3
IFN-beta 3.1
ADM 3.1
Taxol 3.0
ROS 3.0
CSF 2.9
Gel 2.8
Glucagon 2.8
IFN-gamma 2.7
Adriamycin 2.5
Albumin 2.4
Angiotensin II 2.4
MAP 2.3
CTX 2.2
CTX 2.2
PTH 1.9
IL-2 1.8
Dermatol 1.6
Monit 1.6
ABC 1.6
CTX 1.4
TiO2 1.2
Asthma 1.0
NADH 0.3
lysine -0.2
Cardiovasc -1.9
Enzyme
retinal dehydrogenase 8.6
methylenetetrahydrofolate dehydrogenase 7.9
SNO 7.7
phosphoserine phosphatase 7.6
methylenetetrahydrofolate dehydrogenase 7.5
proteinase-3 7.3
dihydropteroate synthase 7.2
KLK7 7.2
kynureninase 7.1
neutrophil collagenase 7.1
amylomaltase 7.0
S-adenosyl-L-homocysteine hydrolase 6.6
LTA4 hydrolase 6.4
Omi/HtrA2 6.3
FPS 6.2
caspase-4 6.2
nicotinamide phosphoribosyltransferase 6.1
TMT 6.1
TACE 6.0
transaldolase 6.0
caspase-4 6.0
cyclohydrolase 5.9
lysyl oxidase 5.4
factor C 5.4
heparinase 5.4
dihydrofolate reductase 5.3
MIP 5.2
indoleamine 2,3-dioxygenase 5.2
arginase 5.1
SST 5.1
AGT 5.1
matrix metalloproteinase 2 5.1
ubiquitin-protein ligase 5.0
MMP-3 4.9
NADPH oxidase 4.9
12-lipoxygenase 4.9
PHD 4.9
SPT 4.9
NADPH oxidase 4.8
interstitial collagenase 4.8
histone demethylase 4.8
cathepsin L 4.7
BAL 4.7
ALA synthase 4.7
neuropathy target esterase 4.6
luciferase 4.5
peroxiredoxin 4.3
neutrophil elastase 4.3
LPL 4.3
cathepsin D 4.3
PGM 4.2
acyl-CoA dehydrogenase 4.2
chitinase 4.2
polo-like kinase 1 4.1
caspase-1 4.1
furin 4.0
alpha-amylase 3.9
tryptophan hydroxylase 3.9
cathepsin G 3.9
collagenase 3.8
prostaglandin synthetase 3.8
cathepsin K 3.8
proteinase K 3.7
chondroitinase 3.7
mitogen-activated protein kinase 3.7
cathepsin B 3.7
MMP 3.6
chondroitinase 3.6
matrix metalloproteinase 9 3.6
peroxidase 3.5
ATP synthase 3.5
NOS 3.4
transglutaminase 3.4
MAP 3.4
ceruloplasmin 3.4
chloramphenicol acetyltransferase 3.4
ERK 3.3
trypsin 3.3
lysozyme 3.3
MDP 3.3
tryptase 3.2
glucokinase 3.2
elastase 3.1
NQO1 3.1
glutathione S-transferase 3.0
GSK 3.0
urokinase-type plasminogen activator 2.9
S1 nuclease 2.8
enolase 2.8
NO synthase 2.7
MDR 2.6
plasmin 2.5
IKK 2.4
protein kinase C 2.4
glutamine synthetase 2.4
adenosine deaminase 2.4
adenosine deaminase 2.3
hexokinase 2.3
reverse transcriptase 2.3
lactate dehydrogenase 2.2
kallikrein 2.1
AST 2.1
lipase 2.1
hyaluronidase 2.1
focal adhesion kinase 2.1
AMPK 2.1
ribonuclease 2.0
ribonuclease 2.0
P-glycoprotein 2.0
alanine aminotransferase 2.0
alkaline phosphatase 1.9
phospholipase A2 1.9
caspase-3 1.9
aspartate aminotransferase 1.9
urease 1.9
glutathione peroxidase 1.8
urease 1.8
thymidine kinase 1.8
DNase 1.8
RNase 1.7
calcineurin 1.6
lipoxygenase 1.6
RNase 1.5
tyrosinase 1.5
ACE 1.5
topoisomerase 1.5
glutathione reductase 1.5
CD10 1.4
topoisomerase 1.4
protein kinase 1.4
chymotrypsin 1.3
phosphatidylinositol 3-kinase 1.2
tissue plasminogen activator 1.2
superoxide dismutase 1.2
AMPK 1.1
acid phosphatase 1.0
AMP-activated protein kinase 1.0
PARP 0.9
proteasome 0.9
DNA polymerase 0.6
renin 0.6
MEK 0.5
phospholipase C 0.5
catalase 0.5
endonuclease 0.5
phosphodiesterase 0.5
creatine kinase 0.5
thrombin -0.3
RNA polymerase -0.4
ATPase -1.3
Compound
PPBP 10.1
Narciclasine 10.1
2-hydroxy-3-methoxybenzaldehyde 9.4
5,5-dimethyl-1,3-cyclohexanedione 8.7
Flucloxacillin 8.7
Trenimon 8.6
Tazarotene 7.9
P-D 7.8
3,4-dihydroxybenzaldehyde 7.8
Fibrinopeptide A 7.6
3,4-dihydroxybenzaldehyde 7.4
TTNPB 7.4
DTE 7.1
TIF 6.8
SSH 6.6
Cordycepin 6.4
Cordycepin 6.4
Cordycepin 6.4
IDC 6.4
Pyrimethamine 6.4
Thymine 6.2
DEK 6.1
TACE 6.0
DAMP 6.0
Poly(I:C) 5.9
Dibutyryl cyclic AMP 5.9
Dibutyryl cyclic AMP 5.9
Tumor Necrosis Factor 5.9
Keratin 5.7
Daunorubicin 5.7
AGE 5.7
Leukotriene B4 5.7
Coenzyme A 5.6
PGFM 5.6
FMLP 5.5
Carrageenan 5.5
5-Aza-2'-deoxycytidine 5.5
Heparan sulfate 5.4
Flavonoid 5.4
Phorbol 12-myristate 13-acetate 5.3
Brilliant Blue 5.2
Lip 5.2
TTA 5.2
DAMP 5.2
SO3 5.2
Sulforaphane 5.1
Plasmin 5.1
IPA 5.0
IPA 5.0
IPA 5.0
4-hydroxybenzoic acid 5.0
Methylprednisolone 5.0
IPA 5.0
BAP 5.0
CHIP 5.0
Brefeldin A 5.0
Brefeldin A 5.0
Evans Blue 4.9
Rutin 4.8
THP 4.8
TNF 4.8
THP 4.8
PMA 4.7
Diclofenac 4.6
Doxycycline 4.6
DAG 4.5
Oil Red O 4.5
XTT 4.4
keratan sulfate 4.4
NTA 4.4
MES 4.3
MES 4.3
TOF 4.3
PMA 4.3
BAL 4.3
Oleic acid 4.2
LIN 4.2
ClO 4.2
Prednisolone 4.2
Oil Red O 4.1
TAA 4.0
calcium 3.9
myricetin 3.9
C2H2 3.9
Cbl 3.9
LPC 3.9
STZ 3.8
retinoic acid 3.7
Phorbol 3.7
zinc 3.7
TAR 3.6
PGE 3.6
chromate 3.5
manganese 3.5
ASC 3.5
Cycloheximide 3.5
thioglycollate 3.4
DPP 3.4
Arachidonic acid 3.4
phenazine 3.4
Forskolin 3.3
Fibrinogen 3.3
TNM 3.3
BLM 3.2
Adriamycin 3.2
4-chlorophenyl 3.2
4-chlorophenyl 3.2
DBA 3.2
PPD 3.2
CTP 3.1
DBA 3.1
DBA 3.1
PPD 3.1
ADR 3.1
COX 3.1
PAS 3.1
MAP 3.1
diacetate 3.1
SCC 3.0
trifluoroacetic acid 3.0
trifluoroacetic acid 3.0
trifluoroacetic acid 3.0
trifluoroacetic acid 3.0
Cysteine 3.0
ANS 3.0
Serine 3.0
ANS 3.0
Metformin 3.0
oxalate 2.9
trifluoroacetic acid 2.9
Metformin 2.9
palmitic acid 2.9
Tamoxifen 2.9
methionine 2.8
Tamoxifen 2.8
Glucagon 2.8
H2S 2.8
Prostaglandin 2.8
Prostaglandin 2.8
DBP 2.8
THE 2.7
His 2.7
COS 2.6
PVA 2.6
DBP 2.6
stearic acid 2.6
stearic acid 2.6
Resveratrol 2.6
stearic acid 2.5
UTP 2.5
DHA 2.5
TPA 2.5
PGE2 2.4
DAD 2.4
MDR 2.4
Asp 2.4
retinol 2.4
palmitic acid 2.4
Cyclosporine 2.4
anthracene 2.3
more...