Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05109 (
S100A8
)
1,212
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The calcium-binding S100 proteins are involved in functions such as cell growth, differentiation, migration, adhesion and signal transduction.
S100A8
and S100A9 are highly expressed in a variety of tumor cells, and are implicated in tumor development and progression. However, the role of
S100A8
and S100A9 in nasopharyngeal carcinoma (NPC) cell migration is unclear. The present study investigated the effect of
S100A8
and S100A9 on migration using a NPC cell line,
CNE1
. The
CNE1
cells were transfected with
S100A8
or S100A9 small interfering RNA (siRNA). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect
S100A8
and S100A9 gene expression. Following the downregulation of
S100A8
or S100A9, the effects on cell migration were determined using wound-healing assays. The expression of matrix metalloproteinase-7 (MMP7), a member of the MMP family that is associated with tumor cell invasion and migration, was also detected by RT-qPCR.
S100A8
and S100A9 siRNAs effectively suppressed
S100A8
and S100A9 gene expression, and substantially inhibited the migration of the
CNE1
cells. In addition, MMP7 expression was reduced to varying extents in
S100A8
and S100A9 siRNA-treated cells compared with controls. Thus,
S100A8
and S100A9 promoted the migration of
CNE1
NPC cells.
...
PMID:Effects of silencing S100A8 and S100A9 with small interfering RNA on the migration of CNE1 nasopharyngeal carcinoma cells. 2613 2
