Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05109 (
S100A8
)
1,212
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Currently three bona fide dendritic cell (DC) types are distinguished in human blood. Herein we focus on type 2 DCs (DC2s) and compare the three defining markers
CD1c
, CD172, and CD301. When using
CD1c
to define DC2s, a CD14
+
and a CD14
-
subset can be detected. The CD14
+
subset shares features with monocytes, and this includes substantially higher expression levels for CD64, CD115, CD163, and
S100A8
/9. We review the current knowledge of these
CD1c
+
CD14
+
cells as compared to the
CD1c
+
CD14
-
cells with respect to phenotype, function, transcriptomics, and ontogeny. Here, we discuss informative mutations, which suggest that two populations have different developmental requirements. In addition, we cover subsets of CD11c
+
CD8
-
DC2s in the mouse, where CLEC12A
+
ESAM
low
cells, as compared to the CLEC12A
-
ESAM
high
subset, also express higher levels of monocyte-associated markers CD14, CD3, and CD115. Finally, we summarize, for both man and mouse, the data on lower antigen presentation and higher cytokine production in the monocyte-marker expressing DC2 subset, which demonstrate that the DC2 subsets are also functionally distinct.
...
PMID:Subsets of CD1c
+
DCs: Dendritic Cell Versus Monocyte Lineage. 3310 Dec 75
