Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P05109 (
S100A8
)
1,212
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The aetiology and cellular mechanism of chronic inflammatory processes are poorly understood. Macrophages act prominently in the inflammatory response and we report here that they express two calcium-binding proteins. The expression of these proteins, referred to as
MRP-8
and MRP-14, is specific for cells of myeloid origin, namely granulocytes, monocytes and macrophages, and is observed in blood granulocytes and monocytes but not in normal tissue macrophages. In acutely inflamed tissues, macrophages can express MRP-14 but not
MRP-8
, and in chronic inflammations, such as primary chronic
polyarthritis
, infiltrate macrophages express both
MRP-8
and MRP-14. Characterization of
MRP-8
and MRP-14 could therefore be useful to the understanding of cellular processes induced in chronic inflammation.
...
PMID:Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. 331 57
