Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04637 (p53)
77,613 document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
p53 77613
p21 8303
Mol 6846
Bcl-2 5050
Sep 4868
caspase-3 4298
MDM2 3176
mutant p53 3017
p16 2496
Ki-67 2138
tumour suppressor 2001
bcl-2 1895
ATM 1744
cyclin D1 1640
PTEN 1523
proliferating cell nuclear antigen 1422
p73 1399
Mdm2 1383
cytochrome c 1313
p27 1309
AKT 1250
ubiquitin 1247
caspase-9 1246
ras 1246
WAF1 1240
BRCA1 1220
c-myc 1195
KRAS 1194
PARP 1181
MAPK 1180
p63 1176
histone 1172
PI3K 1170
p38 1161
EGFR 1151
proteasome 1138
p53 target 1113
cyclin 1103
mTOR 1099
Fas 980
more...
Disease
cancer 30066
tumor 26657
carcinoma 5540
breast cancer 5022
tumorigenesis 4795
carcinogenesis 4750
adenocarcinoma 2562
lung cancer 2393
hepatocellular carcinoma 2197
tumor progression 2141
ATM 2085
tumor growth 2079
squamous cell carcinoma 2041
colorectal cancer 2002
metastases 1812
leukemia 1800
retinoblastoma 1609
colon cancer 1510
MCF 1454
melanoma 1369
lymphoma 1364
prostate cancer 1251
ovarian cancer 1223
glioma 1175
glioblastoma 1015
dysplasia 975
non-small cell lung cancer 958
gastric cancer 957
cervical cancer 924
acute myeloid leukemia 832
APC 803
ARF 795
chronic lymphocytic leukemia 758
osteosarcoma 755
neuroblastoma 708
B-cell lymphoma 707
bladder cancer 697
lung carcinoma 685
pancreatic cancer 660
adenoma 644
more...
Symptom
starvation 255
collapse 124
pain 99
seizures 95
diarrhea 63
ataxia 62
exhaustion 62
hyperoxia 56
abdominal pain 51
fatigue 41
erythema 40
splenomegaly 38
headache 38
vomiting 36
nausea 33
skin damage 31
functional recovery 31
weakness 26
hypothermia 23
respiratory distress 23
masculinization 22
thinning 22
cachexia 20
cough 20
anesthesia 18
dyspnea 18
chest pain 14
acute stress 14
back pain 13
acidity 11
hepatomegaly 11
discomfort 11
discomfort 10
memory loss 10
epigastric pain 10
HSA 10
low back pain 9
anorexia 9
overweight 8
cerebellar ataxia 8
more...
Drug
ROS 825
lysine 617
Dermatol 450
caffeine 195
Paraffin 156
PFT 141
Mutagen 135
MAP 134
MDM 111
Adriamycin 99
Taxol 95
Monit 95
ascorbate 94
IL-2 92
MDS 81
NADH 80
IFN-gamma 76
ABC 76
vitamin E 72
Cardiovasc 71
CSF 67
Gel 63
G418 63
GEO 59
ETS 58
Bortezomib 56
Arsenic trioxide 56
Etoposide 56
BLM 56
MRC 53
DNase I 49
CPT-11 46
CAM 46
Parkin 45
Parkin 45
AGG 43
p75 42
Asn 41
ADR 40
PTC 40
more...
Enzyme
ERK 3808
caspase-3 3259
mitogen-activated protein kinase 2993
protein kinase 1789
PARP 1385
proteasome 1145
cdc2 969
caspase-9 955
luciferase 820
APC 807
focal adhesion kinase 805
superoxide dismutase 674
catalase 653
caspase-8 631
MEK 502
AMP-activated protein kinase 432
topoisomerase 400
RNA polymerase 370
topoisomerase 368
glutathione S-transferase 365
protein kinase C 356
AMPK 271
AMPK 267
reverse transcriptase 262
beta-galactosidase 260
lactate dehydrogenase 246
phosphatidylinositol 3-kinase 246
P-glycoprotein 240
peroxidase 221
glutathione peroxidase 220
ATPase 220
calcineurin 208
DNA polymerase 191
CD10 182
endonuclease 181
GSK 168
NQO1 159
STK11 151
alanine aminotransferase 147
histone acetyltransferase 145
more...
Compound
DNA 22910
Dec 5396
oxygen 3396
Clin 2237
MTT 1194
serine 1065
arginine 998
urea 959
glucose 799
MDA 786
lysine 760
TNF 681
calcium 671
water 649
tyrosine 646
ATP 597
cysteine 583
nitric oxide 551
threonine 533
hydrogen 515
sodium 480
GSH 479
GSH 479
zinc 464
dUTP 421
DDP 417
methionine 416
boron 390
pyrene 375
phosphate 368
NAD 364
iodine 359
bromide 352
MEK 351
proline 351
alanine 341
acetate 320
N-acetylcysteine 315
pyrimidine 312
pyrimidine 309
more...