Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
p53
77613
p21
8303
Mol
6846
Bcl-2
5050
Sep
4868
caspase-3
4298
MDM2
3176
mutant p53
3017
p16
2496
Ki-67
2138
tumour suppressor
2001
bcl-2
1895
ATM
1744
cyclin D1
1640
PTEN
1523
proliferating cell nuclear antigen
1422
p73
1399
Mdm2
1383
cytochrome c
1313
p27
1309
AKT
1250
ubiquitin
1247
caspase-9
1246
ras
1246
WAF1
1240
BRCA1
1220
c-myc
1195
KRAS
1194
PARP
1181
MAPK
1180
p63
1176
histone
1172
PI3K
1170
p38
1161
EGFR
1151
proteasome
1138
p53 target
1113
cyclin
1103
mTOR
1099
Fas
980
more...
Disease
cancer
30066
tumor
26657
carcinoma
5540
breast cancer
5022
tumorigenesis
4795
carcinogenesis
4750
adenocarcinoma
2562
lung cancer
2393
hepatocellular carcinoma
2197
tumor progression
2141
ATM
2085
tumor growth
2079
squamous cell carcinoma
2041
colorectal cancer
2002
metastases
1812
leukemia
1800
retinoblastoma
1609
colon cancer
1510
MCF
1454
melanoma
1369
lymphoma
1364
prostate cancer
1251
ovarian cancer
1223
glioma
1175
glioblastoma
1015
dysplasia
975
non-small cell lung cancer
958
gastric cancer
957
cervical cancer
924
acute myeloid leukemia
832
APC
803
ARF
795
chronic lymphocytic leukemia
758
osteosarcoma
755
neuroblastoma
708
B-cell lymphoma
707
bladder cancer
697
lung carcinoma
685
pancreatic cancer
660
adenoma
644
more...
Symptom
starvation
255
collapse
124
pain
99
seizures
95
diarrhea
63
ataxia
62
exhaustion
62
hyperoxia
56
abdominal pain
51
fatigue
41
erythema
40
splenomegaly
38
headache
38
vomiting
36
nausea
33
skin damage
31
functional recovery
31
weakness
26
hypothermia
23
respiratory distress
23
masculinization
22
thinning
22
cachexia
20
cough
20
anesthesia
18
dyspnea
18
chest pain
14
acute stress
14
back pain
13
acidity
11
hepatomegaly
11
discomfort
11
discomfort
10
memory loss
10
epigastric pain
10
HSA
10
low back pain
9
anorexia
9
overweight
8
cerebellar ataxia
8
more...
Drug
ROS
825
lysine
617
Dermatol
450
caffeine
195
Paraffin
156
PFT
141
Mutagen
135
MAP
134
MDM
111
Adriamycin
99
Taxol
95
Monit
95
ascorbate
94
IL-2
92
MDS
81
NADH
80
IFN-gamma
76
ABC
76
vitamin E
72
Cardiovasc
71
CSF
67
Gel
63
G418
63
GEO
59
ETS
58
Bortezomib
56
Arsenic trioxide
56
Etoposide
56
BLM
56
MRC
53
DNase I
49
CPT-11
46
CAM
46
Parkin
45
Parkin
45
AGG
43
p75
42
Asn
41
ADR
40
PTC
40
more...
Enzyme
ERK
3808
caspase-3
3259
mitogen-activated protein kinase
2993
protein kinase
1789
PARP
1385
proteasome
1145
cdc2
969
caspase-9
955
luciferase
820
APC
807
focal adhesion kinase
805
superoxide dismutase
674
catalase
653
caspase-8
631
MEK
502
AMP-activated protein kinase
432
topoisomerase
400
RNA polymerase
370
topoisomerase
368
glutathione S-transferase
365
protein kinase C
356
AMPK
271
AMPK
267
reverse transcriptase
262
beta-galactosidase
260
lactate dehydrogenase
246
phosphatidylinositol 3-kinase
246
P-glycoprotein
240
peroxidase
221
glutathione peroxidase
220
ATPase
220
calcineurin
208
DNA polymerase
191
CD10
182
endonuclease
181
GSK
168
NQO1
159
STK11
151
alanine aminotransferase
147
histone acetyltransferase
145
more...
Compound
DNA
22910
Dec
5396
oxygen
3396
Clin
2237
MTT
1194
serine
1065
arginine
998
urea
959
glucose
799
MDA
786
lysine
760
TNF
681
calcium
671
water
649
tyrosine
646
ATP
597
cysteine
583
nitric oxide
551
threonine
533
hydrogen
515
sodium
480
GSH
479
GSH
479
zinc
464
dUTP
421
DDP
417
methionine
416
boron
390
pyrene
375
phosphate
368
NAD
364
iodine
359
bromide
352
MEK
351
proline
351
alanine
341
acetate
320
N-acetylcysteine
315
pyrimidine
312
pyrimidine
309
more...