Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04637 (p53)
 77,613 document(s) hit in 31,850,051 MEDLINE articles (0.06 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
p53 77613
p21 8303
Mol 6846
Bcl-2 5050
Sep 4868
caspase-3 4298
MDM2 3176
mutant p53 3017
p16 2496
Ki-67 2138
tumour suppressor 2001
bcl-2 1895
ATM 1744
cyclin D1 1640
PTEN 1523
proliferating cell nuclear antigen 1422
p73 1399
Mdm2 1383
cytochrome c 1313
p27 1309
AKT 1250
ubiquitin 1247
caspase-9 1246
ras 1246
WAF1 1240
BRCA1 1220
c-myc 1195
KRAS 1194
PARP 1181
MAPK 1180
p63 1176
histone 1172
PI3K 1170
p38 1161
EGFR 1151
proteasome 1138
p53 target 1113
cyclin 1103
mTOR 1099
Fas 980
estrogen receptor 954
epidermal growth factor receptor 913
c-Myc 897
pRb 895
INK4a 891
bax 882
K-ras 845
caspase-8 844
CDKN2A 830
cytokine 829
ROS 825
ERK 805
BRAF 802
JNK 800
ARF 794
CIP1 790
APC 790
PIK3CA 787
HER2 784
catenin 773
cyclin E 767
BAX 752
erbB-2 745
H2AX 711
osteosarcoma 694
MYC 691
TNF 681
p16INK4a 680
Chk1 673
E-cadherin 670
BRCA2 667
cyclin-dependent kinase 642
PUMA 624
CDK4 616
vimentin 609
tumor necrosis factor 608
survivin 604
vascular endothelial growth factor 599
ATP 597
RB1 597
progesterone receptor 585
p300 580
ATR 573
lymphoid 568
ERK1 562
mdm2 558
c-Jun 550
phosphatase 549
E2F1 547
annexin V 546
cyclin-dependent kinase inhibitor 541
cyclin B1 532
endoplasmic reticulum 523
MIB 516
Chk2 511
insulin 509
Li-Fraumeni syndrome 508
cyclin A 500
tyrosine kinase 499
superoxide dismutase 489
histone deacetylase 487
E3 ubiquitin ligase 472
catalase 465
proto-oncogene 463
GSH 454
tumor suppressor protein 449
VEGF 445
SIRT1 445
p65 442
CDK2 441
BCL2 437
CDKN1A 434
beta-catenin 432
IL-6 431
p21 protein 430
p14 417
ubiquitin ligase 411
nodal 403
colon carcinoma 402
STAT3 401
poly(ADP-ribose) polymerase 401
collagen 401
DNA-binding domain 401
cytokeratin 396
CD34 393
DNA-dependent protein kinase 392
cage 391
Bak 386
SMAD4 379
MEK 369
p19 364
NMR 346
Mcl-1 344
interferon 340
H-ras 340
Sp1 339
c-fos 336
A-T 336
neu 336
AP-1 335
histone H3 331
androgen receptor 329
MDM2 protein 326
Cyclin D1 322
Bax protein 322
ataxia telangiectasia mutated 320
IDH1 313
threonine 310
E6 protein 302
NRAS 297
NAD 295
P21 294
telomeric 292
CTNNB1 292
inducible nitric oxide synthase 288
cytochrome 287
HDM2 287
Hdm2 286
ERBB2 285
COX-2 283
more...
Disease
cancer 30066
tumor 26657
carcinoma 5540
breast cancer 5022
tumorigenesis 4795
carcinogenesis 4750
adenocarcinoma 2562
lung cancer 2393
hepatocellular carcinoma 2197
tumor progression 2141
ATM 2085
tumor growth 2079
squamous cell carcinoma 2041
colorectal cancer 2002
metastases 1812
leukemia 1800
retinoblastoma 1609
colon cancer 1510
MCF 1454
melanoma 1369
lymphoma 1364
prostate cancer 1251
ovarian cancer 1223
glioma 1175
glioblastoma 1015
dysplasia 975
non-small cell lung cancer 958
gastric cancer 957
cervical cancer 924
acute myeloid leukemia 832
APC 803
ARF 795
chronic lymphocytic leukemia 758
osteosarcoma 755
neuroblastoma 708
B-cell lymphoma 707
bladder cancer 697
lung carcinoma 685
pancreatic cancer 660
adenoma 644
sarcoma 623
skin cancer 610
primary tumor 584
Li-Fraumeni syndrome 583
chronic lymphocytic leukemia 578
epithelial ovarian cancer 535
liver cancer 528
multiple myeloma 520
Epstein 490
endometrial cancer 481
aggressiveness 477
myelodysplastic syndrome 469
GSH 454
diabetes 443
Alzheimer's disease 420
ischemia 412
glioblastoma multiforme 401
liver cancer 396
hepatitis B 389
brain tumor 379
Leukemia 365
acute lymphoblastic leukemia 353
Hodgkin's disease 351
renal cell carcinoma 347
neoplastic transformation 343
virus infection 318
WT1 317
HIV 308
astrocytoma 302
esophageal cancer 302
chronic myeloid leukemia 287
esophageal cancer 285
Hepatocellular carcinoma 277
atherosclerosis 260
Parkinson's disease 256
anemia 255
oral cancer 252
human papilloma virus 251
human papilloma virus 251
head and neck cancer 251
Barrett's esophagus 251
carcinoma in situ 250
papilloma 240
medulloblastoma 239
infectious diseases 235
obesity 234
aggression 231
Burkitt's lymphoma 224
cold 218
tumor initiation 209
Infection 208
immunodeficiency 202
SCID 200
solid tumor 200
non-Hodgkin's lymphoma 198
small cell lung cancer 197
ductal carcinoma in situ 196
ductal carcinoma 193
hepatitis C 193
cirrhosis 191
PML 188
Hippel 187
basal cell carcinoma 185
acute promyelocytic leukemia 184
mantle cell lymphoma 184
B-cell lymphomas 183
xeroderma pigmentosum 179
ATRX 171
thyroid cancer 171
stroke 170
ulcerative colitis 169
mammary tumor 169
cytomegalovirus 165
Glioblastoma 162
leukemogenesis 160
plaque 159
transitional cell carcinoma 159
tumor angiogenesis 153
mesothelioma 152
Melanoma 150
heart failure 150
rhabdomyosarcoma 148
trisomy 147
fibrosarcoma 142
AIDS 141
invasive cancer 138
Dukes 138
Blocking 137
herpes simplex 137
uterine cervix 137
uterus 137
residual disease 136
DDP 136
hematologic malignancies 136
hypertension 135
AGS 133
FAS 133
mole 132
EMA 130
fallopian tube 129
adrenocortical carcinoma 129
Kaposi's sarcoma 126
suicide 124
colitis 123
EBV infection 119
anaplastic astrocytoma 118
Osteosarcoma 117
Osteosarcoma 117
HCC 115
Adenovirus 114
erythroleukemia 114
B-cell chronic lymphocytic leukemia 113
familial adenomatous polyposis 112
leiomyosarcoma 112
MDM 111
clear cell carcinoma 111
rectal cancer 111
cerebral ischemia 111
Fanconi 110
type 2 diabetes 109
more...
Symptom
starvation 255
collapse 124
pain 99
seizures 95
diarrhea 63
ataxia 62
exhaustion 62
hyperoxia 56
abdominal pain 51
fatigue 41
erythema 40
splenomegaly 38
headache 38
vomiting 36
nausea 33
skin damage 31
functional recovery 31
weakness 26
hypothermia 23
respiratory distress 23
masculinization 22
thinning 22
cough 20
cachexia 20
anesthesia 18
dyspnea 18
chest pain 14
acute stress 14
back pain 13
acidity 11
hepatomegaly 11
discomfort 11
memory loss 10
epigastric pain 10
discomfort 10
HSA 10
low back pain 9
anorexia 9
overweight 8
cerebellar ataxia 8
dysuria 7
hepatosplenomegaly 7
sore throat 6
paraparesis 6
Ill 6
ENT 6
nausea and vomiting 6
hemoptysis 5
abdominal discomfort 5
bone pain 5
constipation 5
DNA marker 5
dizziness 5
decreased appetite 5
Scratch 5
hypotonia 5
tremor 4
abdominal fullness 4
paresis 4
tingling 4
pelvic pain 4
vertigo 4
hoarseness 4
numbness 4
nipple discharge 4
nipple discharge 4
angina 4
arthralgia 4
bradykinesia 4
paresthesia 4
pachyonychia 3
stigma 3
forgetfulness 3
lethargy 3
neck pain 3
hypercapnia 3
anal pain 3
exertional dyspnea 3
chills 3
syncope 3
blurred vision 3
facial pain 3
flank pain 3
analgesia 3
flushing 3
male subfertility 2
cancer pain 2
distraction 2
colic 2
dry eye 2
menopausal symptoms 2
tenesmus 2
neurological disability 2
hypoproteinemia 2
shortness of breath 2
stridor 2
dystonia 2
urinary frequency 2
Anoxia 2
Physical findings 2
Fluctuation 2
right upper quadrant pain 2
ophthalmoplegia 2
asthenia 2
fever of unknown origin 2
disturbed balance 2
insomnia 2
Noise-induced hearing loss 1
heartburn 1
hemiplegia 1
myalgia 1
shoulder pain 1
twitching 1
consciousness disturbance 1
acute pain 1
personality change 1
partial seizure 1
incoordination 1
Neurologic symptoms 1
Neuropathic pain 1
Respiratory symptoms 1
Tenderness 1
peri-menopausal 1
labored breathing 1
acute abdomen 1
polydipsia 1
skin irritation 1
bloating 1
Grimace 1
CSR 1
Mucosal hyperplasia 1
chorea 1
intention tremor 1
No adverse effect 1
spasm 1
physical appearance 1
urethral discharge 1
night sweats 1
Depressive symptoms 1
Sister Mary Joseph's nodule 1
tense 1
clubbing 1
intestinal bleeding 1
abnormal breathing 1
regurgitation 1
pallor 1
wrist pain 1
scaly skin 1
emaciation 1
Skin thickening 1
female puberty 1
cardiovascular problem 1
rundown 1
Flu-like symptoms 1
tachypnea 1
joint stiffness 1
RNA marker 1
left upper quadrant pain 1
impaired motor coordination 1
clumsiness 1
more...
Drug
ROS 825
lysine 617
Dermatol 450
caffeine 195
Paraffin 156
PFT 141
Mutagen 135
MAP 134
MDM 111
Adriamycin 99
Monit 95
Taxol 95
ascorbate 94
IL-2 92
MDS 81
NADH 80
ABC 76
IFN-gamma 76
vitamin E 72
Cardiovasc 71
CSF 67
G418 63
Gel 63
GEO 59
ETS 58
BLM 56
Bortezomib 56
Etoposide 56
Arsenic trioxide 56
MRC 53
DNase I 49
CPT-11 46
CAM 46
Parkin 45
Parkin 45
AGG 43
p75 42
Asn 41
PTC 40
ADR 40
TTC 39
TAT 38
Glutathione 37
VCR 34
Imatinib 34
Oxaliplatin 33
ZnO 33
ADM 32
uPA 31
Docetaxel 31
NVP 31
CTX 30
Retinoic acid 30
Heme 27
ROC 27
Irinotecan 26
TAC 26
-deoxyadenosine 25
CDX 24
Angiotensin II 24
Gefitinib 24
CDX 24
Rituximab 23
EE2 23
Fluorescein 23
Sorafenib 22
Ethanol 22
Indomethacin 22
ENT 21
Meth 21
IFN-beta 21
Nitric Oxide 20
Simvastatin 20
CED 19
Gleevec 19
G-CSF 19
CCL 18
Vorinostat 18
Leaf 18
Lenalidomide 17
Vitamin E 17
Fludarabine 16
ICI 16
Biopolymers 16
TiO2 16
Epigallocatechin 16
CTC 16
Portal 16
Spectrum 16
AMC 15
Lovastatin 15
Flavopiridol 15
Cetuximab 15
FAD 15
Bevacizumab 15
Albumin 15
Taxotere 14
CoCl2 14
Herceptin 14
TEL 14
CoCl2 14
ALA 13
Glycyrrhiza 13
Pemetrexed 13
lactose 13
CTC 13
ACT 13
Amifostine 13
niacin 13
AZT 12
CTT 12
Photofrin 12
Emodin 12
Campath 12
Ginseng 12
Emodin 12
citric acid 12
Campath 12
Activin 12
DMAP 12
AZT 12
Doxycycline 11
AraC 11
VCR 11
Estrogens 11
Erlotinib 10
BH4 10
Propidium 10
Growth hormone 10
Alliance 10
Itraconazole 10
Growth hormone 10
Vitamin A 10
CDP 9
HCH 9
2-Methoxyestradiol 9
Fragment 9
MOF 9
Alanine 9
Fraction 9
KGF 8
Dasatinib 8
Silica 8
Advexin 8
Nephron 8
DHT 8
Artesunate 8
nitroglycerin 8
RFP 8
DHT 8
Retinoic Acid 7
ID2 7
Rutin 7
PTH 7
Vitamin K 7
Gelatin 7
Fulvestrant 7
Cidofovir 7
HCG 7
Forskolin 7
more...
Enzyme
ERK 3808
caspase-3 3259
mitogen-activated protein kinase 2993
protein kinase 1789
PARP 1385
proteasome 1145
cdc2 969
caspase-9 955
luciferase 820
APC 807
focal adhesion kinase 805
superoxide dismutase 674
catalase 653
caspase-8 631
MEK 502
AMP-activated protein kinase 432
topoisomerase 400
RNA polymerase 370
topoisomerase 368
glutathione S-transferase 365
protein kinase C 356
AMPK 271
AMPK 267
reverse transcriptase 262
beta-galactosidase 260
phosphatidylinositol 3-kinase 246
lactate dehydrogenase 246
P-glycoprotein 240
peroxidase 221
ATPase 220
glutathione peroxidase 220
calcineurin 208
DNA polymerase 191
CD10 182
endonuclease 181
GSK 168
NQO1 159
STK11 151
alanine aminotransferase 147
histone acetyltransferase 145
phosphoinositide 3-kinase 140
thymidine kinase 140
thymidylate synthase 138
aspartate aminotransferase 130
alkaline phosphatase 129
DNA methyltransferase 126
caspase-1 123
caspase-2 110
MAP 107
cathepsin D 105
IKK 105
ACS 105
RNase 105
caspase-2 105
ribonucleotide reductase 104
TdT 101
RNase 101
ribonucleotide reductase 100
caspase-7 97
caspase-7 94
collagenase 93
polo-like kinase 1 92
NADPH oxidase 91
NADPH oxidase 85
protein phosphatase 2A 85
urokinase-type plasminogen activator 82
glyceraldehyde-3-phosphate dehydrogenase 79
ornithine decarboxylase 78
glutathione reductase 75
prostate-specific antigen 73
NO synthase 73
complex I 68
dihydrofolate reductase 67
chloramphenicol acetyltransferase 67
isocitrate dehydrogenase 67
MDR 64
demethylase 64
gamma-glutamyl transpeptidase 64
isocitrate dehydrogenase 63
MMP 62
CEP 61
CEP 61
AST 61
NOS 60
ubiquitin-protein ligase 59
transcriptase 55
DNA ligase 52
DNA ligase 52
creatine kinase 52
PDK1 49
CGT 48
trypsin 47
enolase 44
thioredoxin reductase 42
tyrosine hydroxylase 42
caspase-6 41
hypoxanthine-guanine phosphoribosyltransferase 40
glyceraldehyde-3-phosphate dehydrogenase 40
cathepsin B 40
caspase-6 40
heme oxygenase 40
lysozyme 40
tyrosinase 40
phospholipase C 39
AGT 39
acetylcholinesterase 39
TAT 38
MMP-3 38
TOR 36
renin 36
histone demethylase 35
glucose-6-phosphate dehydrogenase 35
DNase 34
glyceraldehyde-3-phosphate dehydrogenase 33
thymidine phosphorylase 33
granzyme B 33
peroxiredoxin 32
dihydropyrimidine dehydrogenase 31
glyceraldehyde-3-phosphate dehydrogenase 31
transglutaminase 31
glyceraldehyde-3-phosphate dehydrogenase 31
TGT 30
MEKK1 30
MPP 30
succinate dehydrogenase 30
aldehyde dehydrogenase 29
farnesyltransferase 29
CAD 29
CAD 29
CAD 29
BAT 28
farnesyltransferase 27
thrombin 26
phosphodiesterase 26
TSA 26
pyruvate kinase 25
matrix metalloproteinase 9 24
CYP3A4 24
DCF 24
PAH 24
aldehyde dehydrogenase 24
aldehyde dehydrogenase 24
aldehyde dehydrogenase 24
aldehyde dehydrogenase 24
hexokinase 24
dihydropyrimidine dehydrogenase 23
cytochrome oxidase 23
xanthine oxidase 22
phospholipase A2 22
ribonuclease 22
ribonuclease 22
prolyl hydroxylase 22
acetyl-CoA carboxylase 22
cytosine deaminase 21
kinesin 21
pyruvate dehydrogenase 21
ACE 20
carbonic anhydrase 20
ATP synthase 20
firefly luciferase 19
more...
Compound
DNA 22910
Dec 5396
oxygen 3396
Clin 2237
MTT 1194
serine 1065
arginine 998
urea 959
glucose 799
MDA 786
lysine 760
TNF 681
calcium 671
water 649
tyrosine 646
ATP 597
cysteine 583
nitric oxide 551
threonine 533
hydrogen 515
sodium 480
GSH 479
GSH 479
zinc 464
dUTP 421
DDP 417
methionine 416
boron 390
pyrene 375
phosphate 368
NAD 364
iodine 359
bromide 352
MEK 351
proline 351
alanine 341
acetate 320
N-acetylcysteine 315
pyrimidine 312
pyrimidine 309
retinoic acid 307
iron 301
ADP-ribose 297
NAD 295
TNM 281
Adriamycin 279
His 264
H2O2 259
nitrogen 253
ADP 233
leucine 224
ADR 224
ethanol 217
ADP 217
ADP 217
copper 207
DCC 202
Curcumin 202
CAT 199
CAT 198
CAT 198
5-FU 196
cAMP 196
Resveratrol 195
caffeine 195
sulfate 192
aflatoxin B1 190
nicotinamide 190
anthracene 175
Asp 173
Pac 168
NH2 161
selenium 156
glutamate 152
formaldehyde 152
NOXA 151
silver 141
cadmium 139
salt 138
SCC 138
AMP 136
creatinine 131
galactose 130
glutamine 126
DBA 124
acridine 120
tryptophan 117
Phe 117
Histone 117
VP-16 109
MAP 106
BCR 105
ACS 104
ACS 104
8-OHdG 101
Ubiquitin 101
NADPH 100
NADPH 100
GTP 99
PEG 96
Estrogen 94
Serine 93
ABL 93
potassium 92
methanol 87
Panam 86
BLM 85
SDS 84
benzene 84
TPA 82
Ile 82
TPA 81
vitamin D 80
NADH 80
Estrogen 79
pentose 78
chromium 78
pentose 77
pentose 77
Melatonin 77
Gly 77
pentose 77
ASA 75
COS 75
Vimentin 74
Insulin 74
Paclitaxel 73
pyridine 72
Quercetin 71
ATF 70
DMSO 70
Arsenic 70
Cyt 69
manganese 68
adenosylmethionine 68
aldehyde 67
diacetate 66
methyl methanesulfonate 65
MDR 64
TEM 64
PEG 64
Rapamycin 63
tryptophan 63
XPA 63
cobalt 63
XPA 63
CCC 62
tryptophan 61
MTS 61
CAM 61
PMA 61
Hoechst 33342 61
tryptophan 61
Metformin 60
Metformin 60
COX 60
THP 60
nickel 60
Neuronal 60
Cu(II) 58
more...