Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
p53 protein
is a sequence-specific transcription factor that plays a crucial role in tumor suppression by inducing apoptosis or cell cycle arrest in response to cellular damage. To identify novel proteins involved in the regulation of
p53
transcriptional activity we have performed a large scale RNA interference-based screen. We have identified four genes previously unknown to be involved in modulating
p53
activity (GAS41, RPS6K4,
RUNDC1
and CRMP-2). The interference of each of these four genes resulted in the upregulation of
p53
transcriptional activity and, conversely, their overexpression resulted in the inhibition of p53 target promoters and
p53
-mediated apoptosis. These observations suggest a role for these genes as
p53
inhibitors and imply that they may have oncogenic activity.
...
PMID:A high-throughput loss-of-function screening identifies novel p53 regulators. 1692 79
